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Protein

NADH oxidoreductase HCR

Gene

hcr

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

NADH oxidoreductase acting in concert with HCP.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi273Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi278Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi281Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi311Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1

GO - Molecular functioni

  • 2 iron, 2 sulfur cluster binding Source: EcoCyc
  • electron transfer activity Source: InterPro
  • flavin adenine dinucleotide binding Source: EcoCyc
  • metal ion binding Source: UniProtKB-KW
  • oxidoreductase activity, acting on NAD(P)H Source: EcoCyc

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport
Ligand2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, NAD

Enzyme and pathway databases

BioCyciEcoCyc:G6456-MONOMER
MetaCyc:G6456-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NADH oxidoreductase HCR (EC:1.-.-.-)
Gene namesi
Name:hcr
Synonyms:ybjV
Ordered Locus Names:b0872, JW5117
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Organism-specific databases

EcoGeneiEG13691 hcr

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000839281 – 322NADH oxidoreductase HCRAdd BLAST322

Proteomic databases

PaxDbiP75824
PRIDEiP75824

Interactioni

Protein-protein interaction databases

BioGridi4262097, 14 interactors
IntActiP75824, 16 interactors
STRINGi316385.ECDH10B_0942

Structurei

3D structure databases

ProteinModelPortaliP75824
SMRiP75824
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 107FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST101
Domaini237 – 3222Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 213OxidoreductaseAdd BLAST103

Sequence similaritiesi

In the N-terminal section; belongs to the FAD-binding oxidoreductase type 6 family.Curated

Phylogenomic databases

eggNOGiENOG4105CJJ Bacteria
COG1018 LUCA
HOGENOMiHOG000141050
InParanoidiP75824
KOiK11933
OMAiMQVHHIH
PhylomeDBiP75824

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR012675 Beta-grasp_dom_sf
IPR017927 Fd_Rdtase_FAD-bd
IPR008333 OxRdtase_FAD-bd_dom
IPR001433 OxRdtase_FAD/NAD-bd
IPR000951 Ph_dOase_redase
IPR017938 Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF00970 FAD_binding_6, 1 hit
PF00111 Fer2, 1 hit
PF00175 NAD_binding_1, 1 hit
PRINTSiPR00409 PHDIOXRDTASE
SUPFAMiSSF54292 SSF54292, 1 hit
SSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS51384 FAD_FR, 1 hit

Sequencei

Sequence statusi: Complete.

P75824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMPTNQCPW RMQVHHITQE TPDVWTISLI CHDYYPYRAG QYALVSVRNS
60 70 80 90 100
AETLRAYTIS STPGVSEYIT LTVRRIDDGV GSQWLTRDVK RGDYLWLSDA
110 120 130 140 150
MGEFTCDDKA EDKFLLLAAG CGVTPIMSMR RWLAKNRPQA DVRVIYNVRT
160 170 180 190 200
PQDVIFADEW RNYPVTLVAE NNVTEGFIAG RLTRELLAGV PDLASRTVMT
210 220 230 240 250
CGPAPYMDWV EQEVKALGVT RFFKEKFFTP VAEAATSGLK FTKLQPAREF
260 270 280 290 300
YAPVGTTLLE ALESNNVPVV AACRAGVCGC CKTKVVSGEY TVSSTMTLTD
310 320
AEIAEGYVLA CSCHPQGDLV LA
Length:322
Mass (Da):35,740
Last modified:May 30, 2000 - v3
Checksum:i5138026DCBBD6A9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73959.1
AP009048 Genomic DNA Translation: BAA35586.2
PIRiH64825
RefSeqiNP_415393.1, NC_000913.3
WP_000178677.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73959; AAC73959; b0872
BAA35586; BAA35586; BAA35586
GeneIDi947660
KEGGiecj:JW5117
eco:b0872
PATRICifig|1411691.4.peg.1405

Entry informationi

Entry nameiHCR_ECOLI
AccessioniPrimary (citable) accession number: P75824
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: March 28, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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