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P75817 (RLMC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

EC=2.1.1.189
Alternative name(s):
23S rRNA(m5U747)-methyltransferase
Gene names
Name:rlmC
Synonyms:rumB, ybjF
Ordered Locus Names:b0859, JW0843
OrganismEscherichia coli (strain K12)
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA. Ref.4

Catalytic activity

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA. Ref.4

Sequence similarities

Belongs to the methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 37537523S rRNA (uracil(747)-C(5))-methyltransferase RlmC HAMAP MF_01012
PRO_0000161925

Sites

Active site3341Nucleophile By similarity
Metal binding31Iron-sulfur (4Fe-4S) By similarity
Metal binding111Iron-sulfur (4Fe-4S) By similarity
Metal binding141Iron-sulfur (4Fe-4S) By similarity
Metal binding871Iron-sulfur (4Fe-4S) By similarity
Binding site2121S-adenosyl-L-methionine By similarity
Binding site2411S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site2621S-adenosyl-L-methionine By similarity
Binding site3071S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
P75817 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: EDFE591BE2B9DE7D

FASTA37541,956
        10         20         30         40         50         60 
MQCALYDAGR CRSCQWIMQP IPEQLSAKTA DLKNLLADFP VEEWCAPVSG PEQGFRNKAK 

        70         80         90        100        110        120 
MVVSGSVEKP LLGMLHRDGT PEDLCDCPLY PASFAPVFAA LKPFIARAGL TPYNVARKRG 

       130        140        150        160        170        180 
ELKYILLTES QSDGGMMLRF VLRSDTKLAQ LRKALPWLHE QLPQLKVITV NIQPVHMAIM 

       190        200        210        220        230        240 
EGETEIYLTE QQALAERFND VPLWIRPQSF FQTNPAVASQ LYATARDWVR QLPVKHMWDL 

       250        260        270        280        290        300 
FCGVGGFGLH CATPDMQLTG IEIASEAIAC AKQSAAELGL TRLQFQALDS TQFATAQGDV 

       310        320        330        340        350        360 
PELVLVNPPR RGIGKPLCDY LSTMAPRFII YSSCNAQTMA KDIRELPGFR IERVQLFDMF 

       370 
PHTAHYEVLT LLVKQ 

« Hide

References

« Hide 'large scale' references
[1]"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map."
Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. expand/collapse author list , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T.
DNA Res. 3:137-155(1996) [PubMed: 8905232] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Identifying the methyltransferases for m(5)U747 and m(5)U1939 in 23S rRNA using MALDI mass spectrometry."
Madsen C.T., Mengel-Joergensen J., Kirpekar F., Douthwaite S.
Nucleic Acids Res. 31:4738-4746(2003) [PubMed: 12907714] [Abstract]
Cited for: FUNCTION, CATALYTIC ACTIVITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00096 Genomic DNA. Translation: AAC73946.1.
AP009048 Genomic DNA. Translation: BAA35573.1.
PIRC64824.
RefSeqNP_415380.1. NC_000913.2.

3D structure databases

ProteinModelPortalP75817.
SMRP75817. Positions 2-373.
ModBaseSearch...

Protein-protein interaction databases

IntActP75817. 8 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000003640; EBESCP00000003640; EBESCG00000002973.
EBESCT00000017223; EBESCP00000016514; EBESCG00000016282.
GeneID947260.
GenomeReviewsGene locus JW0843 in contig AP009048_GR.
Gene locus b0859 in contig U00096_GR.
KEGGecj:JW0843.
eco:b0859.
PATRIC32116923. VBIEscCol129921_0887.

Organism-specific databases

EchoBASEEB3201.
EcoGeneEG13427. rlmC.

Phylogenomic databases

eggNOGCOG2265.
GeneTreeEBGT00050000009928.
HOGENOMHBG296593.
OMAIMEGERE.
PhylomeDBP75817.
ProtClustDBPRK03522.

Enzyme and pathway databases

BioCycEcoCyc:G6449-MONOMER.
MetaCyc:G6449-MONOMER.

Gene expression databases

GenevestigatorP75817.

Family and domain databases

HAMAPMF_01012. 23SrRNA_methyltr_RlmC.
[Tree]
InterProIPR011825. MeTrfase_RumB.
IPR010280. U5_MeTrfase.
[Graphical view]
KOK03212.
PfamPF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view]
TIGRFAMsTIGR02085. Meth_trns_rumB. 1 hit.
PROSITEPS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRLMC_ECOLI
AccessionPrimary (citable) accession number: P75817
Secondary accession number(s): Q9R7R3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families