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Protein

Soluble aldose sugar dehydrogenase YliI

Gene

yliI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Aldose sugar dehydrogenase with broad substrate specificity. The physiological substrate is unknown. Can oxidize glucose to gluconolactone. Can also utilize D-arabinose, L-arabinose and 2-deoxy-glucose. Has higher activity towards oligomeric sugars, such as maltose, maltotriose or cellobiose. It may function to input sugar-derived electrons into the respiratory network.1 Publication

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82PQQ1 Publication1
Active sitei147Proton acceptorBy similarity1
Metal bindingi240Calcium1 Publication1
Metal bindingi250Calcium; via carbonyl oxygen1 Publication1
Binding sitei261PQQ1 Publication1

GO - Molecular functioni

  • calcium ion binding Source: EcoCyc
  • oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor Source: EcoCyc
  • pyrroloquinoline quinone binding Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Calcium, Metal-binding, PQQ

Enzyme and pathway databases

BioCyciEcoCyc:G6437-MONOMER.
ECOL316407:JW0821-MONOMER.
MetaCyc:G6437-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Soluble aldose sugar dehydrogenase YliI (EC:1.1.5.-)
Short name:
Asd
Gene namesi
Name:yliI
Ordered Locus Names:b0837, JW0821
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13480. yliI.

Subcellular locationi

GO - Cellular componenti

  • outer membrane-bounded periplasmic space Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002558421 – 371Soluble aldose sugar dehydrogenase YliIAdd BLAST351

Proteomic databases

PaxDbiP75804.
PRIDEiP75804.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi4261449. 276 interactors.
IntActiP75804. 2 interactors.
STRINGi511145.b0837.

Structurei

Secondary structure

1371
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 42Combined sources18
Beta strandi49 – 53Combined sources5
Turni54 – 56Combined sources3
Beta strandi57 – 62Combined sources6
Turni63 – 65Combined sources3
Beta strandi84 – 90Combined sources7
Helixi94 – 97Combined sources4
Beta strandi99 – 107Combined sources9
Beta strandi109 – 111Combined sources3
Beta strandi113 – 122Combined sources10
Beta strandi126 – 137Combined sources12
Beta strandi143 – 146Combined sources4
Beta strandi152 – 154Combined sources3
Beta strandi156 – 164Combined sources9
Helixi170 – 174Combined sources5
Beta strandi182 – 187Combined sources6
Turni197 – 200Combined sources4
Beta strandi208 – 211Combined sources4
Beta strandi214 – 222Combined sources9
Turni223 – 226Combined sources4
Beta strandi227 – 233Combined sources7
Beta strandi235 – 237Combined sources3
Beta strandi239 – 242Combined sources4
Turni252 – 254Combined sources3
Beta strandi257 – 259Combined sources3
Beta strandi271 – 273Combined sources3
Beta strandi281 – 286Combined sources6
Beta strandi290 – 296Combined sources7
Beta strandi299 – 301Combined sources3
Helixi302 – 304Combined sources3
Beta strandi307 – 312Combined sources6
Turni313 – 316Combined sources4
Beta strandi317 – 324Combined sources8
Beta strandi327 – 335Combined sources9
Helixi336 – 338Combined sources3
Beta strandi342 – 347Combined sources6
Beta strandi353 – 357Combined sources5
Beta strandi362 – 368Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G8SX-ray1.50A/B21-370[»]
ProteinModelPortaliP75804.
SMRiP75804.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP75804.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni214 – 215PQQ2
Regioni312 – 314PQQ3
Regioni341 – 343PQQ3

Sequence similaritiesi

Belongs to the PQQ oxidoreductase GdhB family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105D8V. Bacteria.
COG2133. LUCA.
HOGENOMiHOG000246901.
InParanoidiP75804.
OMAiTIYLCYA.
PhylomeDBiP75804.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR012938. Glc/Sorbosone_DH.
IPR011041. Quinoprot_gluc/sorb_DH.
[Graphical view]
PfamiPF07995. GSDH. 1 hit.
[Graphical view]
SUPFAMiSSF50952. SSF50952. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P75804-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRQSFFLVP LICLSSALWA APATVNVEVL QDKLDHPWAL AFLPDNHGML
60 70 80 90 100
ITLRGGELRH WQAGKGLSAP LSGVPDVWAH GQGGLLDVVL APDFAQSRRI
110 120 130 140 150
WLSYSEVGDD GKAGTAVGYG RLSDDLSKVT DFRTVFRQMP KLSTGNHFGG
160 170 180 190 200
RLVFDGKGYL FIALGENNQR PTAQDLDKLQ GKLVRLTDQG EIPDDNPFIK
210 220 230 240 250
ESGARAEIWS YGIRNPQGMA MNPWSNALWL NEHGPRGGDE INIPQKGKNY
260 270 280 290 300
GWPLATWGIN YSGFKIPEAK GEIVAGTEQP VFYWKDSPAV SGMAFYNSDK
310 320 330 340 350
FPQWQQKLFI GALKDKDVIV MSVNGDKVTE DGRILTDRGQ RIRDVRTGPD
360 370
GYLYVLTDES SGELLKVSPR N
Length:371
Mass (Da):41,054
Last modified:February 1, 1997 - v1
Checksum:i99DB08FA302F50B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73924.1.
AP009048 Genomic DNA. Translation: BAA35540.1.
PIRiE64821.
RefSeqiNP_415358.1. NC_000913.3.
WP_000555031.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73924; AAC73924; b0837.
BAA35540; BAA35540; BAA35540.
GeneIDi945467.
KEGGiecj:JW0821.
eco:b0837.
PATRICi32116877. VBIEscCol129921_0864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73924.1.
AP009048 Genomic DNA. Translation: BAA35540.1.
PIRiE64821.
RefSeqiNP_415358.1. NC_000913.3.
WP_000555031.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G8SX-ray1.50A/B21-370[»]
ProteinModelPortaliP75804.
SMRiP75804.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261449. 276 interactors.
IntActiP75804. 2 interactors.
STRINGi511145.b0837.

Proteomic databases

PaxDbiP75804.
PRIDEiP75804.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73924; AAC73924; b0837.
BAA35540; BAA35540; BAA35540.
GeneIDi945467.
KEGGiecj:JW0821.
eco:b0837.
PATRICi32116877. VBIEscCol129921_0864.

Organism-specific databases

EchoBASEiEB3253.
EcoGeneiEG13480. yliI.

Phylogenomic databases

eggNOGiENOG4105D8V. Bacteria.
COG2133. LUCA.
HOGENOMiHOG000246901.
InParanoidiP75804.
OMAiTIYLCYA.
PhylomeDBiP75804.

Enzyme and pathway databases

BioCyciEcoCyc:G6437-MONOMER.
ECOL316407:JW0821-MONOMER.
MetaCyc:G6437-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP75804.
PROiP75804.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR012938. Glc/Sorbosone_DH.
IPR011041. Quinoprot_gluc/sorb_DH.
[Graphical view]
PfamiPF07995. GSDH. 1 hit.
[Graphical view]
SUPFAMiSSF50952. SSF50952. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYLII_ECOLI
AccessioniPrimary (citable) accession number: P75804
Secondary accession number(s): Q9R7R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.