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Protein

Soluble aldose sugar dehydrogenase YliI

Gene

yliI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Aldose sugar dehydrogenase with broad substrate specificity. The physiological substrate is unknown. Can oxidize glucose to gluconolactone. Can also utilize D-arabinose, L-arabinose and 2-deoxy-glucose. Has higher activity towards oligomeric sugars, such as maltose, maltotriose or cellobiose. It may function to input sugar-derived electrons into the respiratory network.1 Publication

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821PQQ1 Publication
Active sitei147 – 1471Proton acceptorBy similarity
Metal bindingi240 – 2401Calcium1 Publication
Metal bindingi250 – 2501Calcium; via carbonyl oxygen1 Publication
Binding sitei261 – 2611PQQ1 Publication

GO - Molecular functioni

  • calcium ion binding Source: EcoCyc
  • oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor Source: EcoCyc
  • pyrroloquinoline quinone binding Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Calcium, Metal-binding, PQQ

Enzyme and pathway databases

BioCyciEcoCyc:G6437-MONOMER.
ECOL316407:JW0821-MONOMER.
MetaCyc:G6437-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Soluble aldose sugar dehydrogenase YliI (EC:1.1.5.-)
Short name:
Asd
Gene namesi
Name:yliI
Ordered Locus Names:b0837, JW0821
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13480. yliI.

Subcellular locationi

GO - Cellular componenti

  • outer membrane-bounded periplasmic space Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 371351Soluble aldose sugar dehydrogenase YliIPRO_0000025584Add
BLAST

Proteomic databases

PaxDbiP75804.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi4261449. 276 interactions.
IntActiP75804. 2 interactions.
STRINGi511145.b0837.

Structurei

Secondary structure

1
371
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi25 – 4218Combined sources
Beta strandi49 – 535Combined sources
Turni54 – 563Combined sources
Beta strandi57 – 626Combined sources
Turni63 – 653Combined sources
Beta strandi84 – 907Combined sources
Helixi94 – 974Combined sources
Beta strandi99 – 1079Combined sources
Beta strandi109 – 1113Combined sources
Beta strandi113 – 12210Combined sources
Beta strandi126 – 13712Combined sources
Beta strandi143 – 1464Combined sources
Beta strandi152 – 1543Combined sources
Beta strandi156 – 1649Combined sources
Helixi170 – 1745Combined sources
Beta strandi182 – 1876Combined sources
Turni197 – 2004Combined sources
Beta strandi208 – 2114Combined sources
Beta strandi214 – 2229Combined sources
Turni223 – 2264Combined sources
Beta strandi227 – 2337Combined sources
Beta strandi235 – 2373Combined sources
Beta strandi239 – 2424Combined sources
Turni252 – 2543Combined sources
Beta strandi257 – 2593Combined sources
Beta strandi271 – 2733Combined sources
Beta strandi281 – 2866Combined sources
Beta strandi290 – 2967Combined sources
Beta strandi299 – 3013Combined sources
Helixi302 – 3043Combined sources
Beta strandi307 – 3126Combined sources
Turni313 – 3164Combined sources
Beta strandi317 – 3248Combined sources
Beta strandi327 – 3359Combined sources
Helixi336 – 3383Combined sources
Beta strandi342 – 3476Combined sources
Beta strandi353 – 3575Combined sources
Beta strandi362 – 3687Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G8SX-ray1.50A/B21-370[»]
ProteinModelPortaliP75804.
SMRiP75804. Positions 24-370.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP75804.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni214 – 2152PQQ
Regioni312 – 3143PQQ
Regioni341 – 3433PQQ

Sequence similaritiesi

Belongs to the PQQ oxidoreductase GdhB family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105D8V. Bacteria.
COG2133. LUCA.
HOGENOMiHOG000246901.
InParanoidiP75804.
OMAiTIYLCYA.
PhylomeDBiP75804.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR012938. Glc/Sorbosone_DH.
IPR011041. Quinoprot_gluc/sorb_DH.
[Graphical view]
PfamiPF07995. GSDH. 1 hit.
[Graphical view]
SUPFAMiSSF50952. SSF50952. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P75804-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRQSFFLVP LICLSSALWA APATVNVEVL QDKLDHPWAL AFLPDNHGML
60 70 80 90 100
ITLRGGELRH WQAGKGLSAP LSGVPDVWAH GQGGLLDVVL APDFAQSRRI
110 120 130 140 150
WLSYSEVGDD GKAGTAVGYG RLSDDLSKVT DFRTVFRQMP KLSTGNHFGG
160 170 180 190 200
RLVFDGKGYL FIALGENNQR PTAQDLDKLQ GKLVRLTDQG EIPDDNPFIK
210 220 230 240 250
ESGARAEIWS YGIRNPQGMA MNPWSNALWL NEHGPRGGDE INIPQKGKNY
260 270 280 290 300
GWPLATWGIN YSGFKIPEAK GEIVAGTEQP VFYWKDSPAV SGMAFYNSDK
310 320 330 340 350
FPQWQQKLFI GALKDKDVIV MSVNGDKVTE DGRILTDRGQ RIRDVRTGPD
360 370
GYLYVLTDES SGELLKVSPR N
Length:371
Mass (Da):41,054
Last modified:February 1, 1997 - v1
Checksum:i99DB08FA302F50B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73924.1.
AP009048 Genomic DNA. Translation: BAA35540.1.
PIRiE64821.
RefSeqiNP_415358.1. NC_000913.3.
WP_000555031.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73924; AAC73924; b0837.
BAA35540; BAA35540; BAA35540.
GeneIDi945467.
KEGGiecj:JW0821.
eco:b0837.
PATRICi32116877. VBIEscCol129921_0864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73924.1.
AP009048 Genomic DNA. Translation: BAA35540.1.
PIRiE64821.
RefSeqiNP_415358.1. NC_000913.3.
WP_000555031.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G8SX-ray1.50A/B21-370[»]
ProteinModelPortaliP75804.
SMRiP75804. Positions 24-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261449. 276 interactions.
IntActiP75804. 2 interactions.
STRINGi511145.b0837.

Proteomic databases

PaxDbiP75804.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73924; AAC73924; b0837.
BAA35540; BAA35540; BAA35540.
GeneIDi945467.
KEGGiecj:JW0821.
eco:b0837.
PATRICi32116877. VBIEscCol129921_0864.

Organism-specific databases

EchoBASEiEB3253.
EcoGeneiEG13480. yliI.

Phylogenomic databases

eggNOGiENOG4105D8V. Bacteria.
COG2133. LUCA.
HOGENOMiHOG000246901.
InParanoidiP75804.
OMAiTIYLCYA.
PhylomeDBiP75804.

Enzyme and pathway databases

BioCyciEcoCyc:G6437-MONOMER.
ECOL316407:JW0821-MONOMER.
MetaCyc:G6437-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP75804.
PROiP75804.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR012938. Glc/Sorbosone_DH.
IPR011041. Quinoprot_gluc/sorb_DH.
[Graphical view]
PfamiPF07995. GSDH. 1 hit.
[Graphical view]
SUPFAMiSSF50952. SSF50952. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYLII_ECOLI
AccessioniPrimary (citable) accession number: P75804
Secondary accession number(s): Q9R7R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.