Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative cyclic di-GMP phosphodiesterase YliE

Gene

yliE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Overexpression reduces biofilm formation. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria.1 Publication

Catalytic activityi

Cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

c-di-GMP

Enzyme and pathway databases

BioCyciEcoCyc:G6433-MONOMER.
ECOL316407:JW0817-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cyclic di-GMP phosphodiesterase YliE (EC:3.1.4.52)
Gene namesi
Name:yliE
Ordered Locus Names:b0833, JW0817
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13476. yliE.

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene have a weak reduction in swarm size.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001687291 – 782Putative cyclic di-GMP phosphodiesterase YliEAdd BLAST782

Proteomic databases

PaxDbiP75800.
PRIDEiP75800.

Interactioni

Protein-protein interaction databases

BioGridi4259986. 11 interactors.
STRINGi511145.b0833.

Structurei

3D structure databases

ProteinModelPortaliP75800.
SMRiP75800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini527 – 781EALPROSITE-ProRule annotationAdd BLAST255

Sequence similaritiesi

Contains 1 EAL domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000118172.
OMAiGFLLHIN.
PhylomeDBiP75800.

Family and domain databases

CDDicd01948. EAL. 1 hit.
Gene3Di3.20.20.450. 1 hit.
InterProiIPR033418. CHASE9.
IPR001633. EAL_dom.
[Graphical view]
PfamiPF17153. CHASE9. 1 hit.
PF00563. EAL. 1 hit.
[Graphical view]
SMARTiSM00052. EAL. 1 hit.
[Graphical view]
SUPFAMiSSF141868. SSF141868. 1 hit.
PROSITEiPS50883. EAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLYEKIKI RLIILFLLAA LSFIGLFFII NYQLVSERAV KRADSRFELI
60 70 80 90 100
QKNVGYFFKD IERSALTLKD SLYLLKNTEE IQRAVILKME MMPFLDSVGL
110 120 130 140 150
VLDDNKYYLF SRRANDKIVV YHQEQVNGPL VDESGRVIFA DFNPSKRPWS
160 170 180 190 200
VASDDSNNSW NPAYNCFDRP GKKCISFTLH INGKDHDLLA VDKIHVDLNW
210 220 230 240 250
RYLNEYLDQI SANDEVLFLK QGHEIIAKNQ LAREKLIIYN SEGNYNIIDS
260 270 280 290 300
VDTEYIEKTS AVPNNALFEI YFYYPGGNLL NASDKLFYLP FAFIIIVLLV
310 320 330 340 350
VYLMTTRVFR RQFSEMTELV NTLAFLPDST DQIEALKIRE GDAKEIISIK
360 370 380 390 400
NSIAEMKDAE IERSNKLLSL ISYDQESGFI KNMAIIESNN NQYLAVGIIK
410 420 430 440 450
LCGLEAVEAV FGVDERNKIV RKLCQRIAEK YAQCCDIVTF NADLYLLLCR
460 470 480 490 500
ENVQTFTRKI AMVNDFDSSF GYRNLRIHKS AICEPLQGEN AWSYAEKLKL
510 520 530 540 550
AISSIRDHMF SEFIFCDDAK LNEIEENIWI ARNIRHAMEI GELFLVYQPI
560 570 580 590 600
VDINTRAILG AEALCRWVSA ERGIISPLKF ITIAEDIGFI NELGYQIIKT
610 620 630 640 650
AMGEFRHFSQ RASLKDDFLL HINVSPWQLN EPHFHERFTT IMKENGLKAN
660 670 680 690 700
SLCVEITETV IERINEHFYL NIEQLRKQGV RISIDDFGTG LSNLKRFYEI
710 720 730 740 750
NPDSIKVDSQ FTGDIFGTAG KIVRIIFDLA RYNRIPVIAE GVESEDVARE
760 770 780
LIKLGCVQAQ GYLYQKPMPF SAWDKSGKLV KE
Length:782
Mass (Da):90,049
Last modified:February 1, 1997 - v1
Checksum:i608DFB0068611DFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73920.1.
AP009048 Genomic DNA. Translation: BAA35528.1.
PIRiA64821.
RefSeqiNP_415354.1. NC_000913.3.
WP_001360263.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73920; AAC73920; b0833.
BAA35528; BAA35528; BAA35528.
GeneIDi945462.
KEGGiecj:JW0817.
eco:b0833.
PATRICi32116869. VBIEscCol129921_0860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73920.1.
AP009048 Genomic DNA. Translation: BAA35528.1.
PIRiA64821.
RefSeqiNP_415354.1. NC_000913.3.
WP_001360263.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP75800.
SMRiP75800.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259986. 11 interactors.
STRINGi511145.b0833.

Proteomic databases

PaxDbiP75800.
PRIDEiP75800.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73920; AAC73920; b0833.
BAA35528; BAA35528; BAA35528.
GeneIDi945462.
KEGGiecj:JW0817.
eco:b0833.
PATRICi32116869. VBIEscCol129921_0860.

Organism-specific databases

EchoBASEiEB3249.
EcoGeneiEG13476. yliE.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000118172.
OMAiGFLLHIN.
PhylomeDBiP75800.

Enzyme and pathway databases

BioCyciEcoCyc:G6433-MONOMER.
ECOL316407:JW0817-MONOMER.

Miscellaneous databases

PROiP75800.

Family and domain databases

CDDicd01948. EAL. 1 hit.
Gene3Di3.20.20.450. 1 hit.
InterProiIPR033418. CHASE9.
IPR001633. EAL_dom.
[Graphical view]
PfamiPF17153. CHASE9. 1 hit.
PF00563. EAL. 1 hit.
[Graphical view]
SMARTiSM00052. EAL. 1 hit.
[Graphical view]
SUPFAMiSSF141868. SSF141868. 1 hit.
PROSITEiPS50883. EAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYLIE_ECOLI
AccessioniPrimary (citable) accession number: P75800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.