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Protein

Glutathione transport system permease protein GsiC

Gene

gsiC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane (Probable).1 Publication

GO - Molecular functioni

  • glutathione transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • glutathione transmembrane transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:YLIC-MONOMER.
ECOL316407:JW0815-MONOMER.
MetaCyc:YLIC-MONOMER.

Protein family/group databases

TCDBi3.A.1.5.11. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione transport system permease protein GsiC
Gene namesi
Name:gsiC
Synonyms:yliC
Ordered Locus Names:b0831, JW0815
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13474. gsiC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini30 – 102PeriplasmicSequence analysisAdd BLAST73
Transmembranei103 – 123HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini124 – 134CytoplasmicSequence analysisAdd BLAST11
Transmembranei135 – 155HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini156 – 168PeriplasmicSequence analysisAdd BLAST13
Transmembranei169 – 189HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini190 – 228CytoplasmicSequence analysisAdd BLAST39
Transmembranei229 – 249HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini250 – 277PeriplasmicSequence analysisAdd BLAST28
Transmembranei278 – 298HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini299 – 306CytoplasmicSequence analysis8

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000602611 – 306Glutathione transport system permease protein GsiCAdd BLAST306

Proteomic databases

PaxDbiP75798.
PRIDEiP75798.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute-binding protein (GsiB).Curated

Protein-protein interaction databases

BioGridi4259983. 3 interactors.
IntActiP75798. 1 interactor.
STRINGi511145.b0831.

Structurei

3D structure databases

ProteinModelPortaliP75798.
SMRiP75798.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 292ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST198

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CJM. Bacteria.
COG0601. LUCA.
HOGENOMiHOG000170251.
InParanoidiP75798.
KOiK13890.
OMAiEVVFQRP.
PhylomeDBiP75798.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNYVIKRLL GLIPTLFIVS VLVFLFVHML PGDPARLIAG PEADAQVIEL
60 70 80 90 100
VRQQLGLDQP LYHQFWHYIS NAVQGDFGLS MVSRRPVADE IASRFMPTLW
110 120 130 140 150
LTITSMVWAV IFGMAAGIIA AVWRNRWPDR LSMTIAVSGI SFPAFALGML
160 170 180 190 200
LIQVFSVELG WLPTVGADSW QHYILPSLTL GAAVAAVMAR FTRASFVDVL
210 220 230 240 250
SEDYMRTARA KGVSETWVVL KHGLRNAMIP VVTMMGLQFG FLLGGSIVVE
260 270 280 290 300
KVFNWPGLGR LLVDSVEMRD YPVIQAEILL FSLEFILINL VVDVLYAAIN

PAIRYK
Length:306
Mass (Da):34,066
Last modified:February 1, 1997 - v1
Checksum:iB74F4D9F2527AECE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73918.1.
AP009048 Genomic DNA. Translation: BAA35526.1.
PIRiG64820.
RefSeqiNP_415352.1. NC_000913.3.
WP_000936043.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73918; AAC73918; b0831.
BAA35526; BAA35526; BAA35526.
GeneIDi945460.
KEGGiecj:JW0815.
eco:b0831.
PATRICi32116865. VBIEscCol129921_0858.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73918.1.
AP009048 Genomic DNA. Translation: BAA35526.1.
PIRiG64820.
RefSeqiNP_415352.1. NC_000913.3.
WP_000936043.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP75798.
SMRiP75798.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259983. 3 interactors.
IntActiP75798. 1 interactor.
STRINGi511145.b0831.

Protein family/group databases

TCDBi3.A.1.5.11. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP75798.
PRIDEiP75798.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73918; AAC73918; b0831.
BAA35526; BAA35526; BAA35526.
GeneIDi945460.
KEGGiecj:JW0815.
eco:b0831.
PATRICi32116865. VBIEscCol129921_0858.

Organism-specific databases

EchoBASEiEB3247.
EcoGeneiEG13474. gsiC.

Phylogenomic databases

eggNOGiENOG4105CJM. Bacteria.
COG0601. LUCA.
HOGENOMiHOG000170251.
InParanoidiP75798.
KOiK13890.
OMAiEVVFQRP.
PhylomeDBiP75798.

Enzyme and pathway databases

BioCyciEcoCyc:YLIC-MONOMER.
ECOL316407:JW0815-MONOMER.
MetaCyc:YLIC-MONOMER.

Miscellaneous databases

PROiP75798.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSIC_ECOLI
AccessioniPrimary (citable) accession number: P75798
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.