Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione transport system permease protein GsiC

Gene

gsiC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane (Probable).1 Publication

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:YLIC-MONOMER
MetaCyc:YLIC-MONOMER

Protein family/group databases

TCDBi3.A.1.5.11 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione transport system permease protein GsiC
Gene namesi
Name:gsiC
Synonyms:yliC
Ordered Locus Names:b0831, JW0815
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Organism-specific databases

EcoGeneiEG13474 gsiC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini30 – 102PeriplasmicSequence analysisAdd BLAST73
Transmembranei103 – 123HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini124 – 134CytoplasmicSequence analysisAdd BLAST11
Transmembranei135 – 155HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini156 – 168PeriplasmicSequence analysisAdd BLAST13
Transmembranei169 – 189HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini190 – 228CytoplasmicSequence analysisAdd BLAST39
Transmembranei229 – 249HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini250 – 277PeriplasmicSequence analysisAdd BLAST28
Transmembranei278 – 298HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini299 – 306CytoplasmicSequence analysis8

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000602611 – 306Glutathione transport system permease protein GsiCAdd BLAST306

Proteomic databases

PaxDbiP75798
PRIDEiP75798

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute-binding protein (GsiB).Curated

Protein-protein interaction databases

BioGridi4259983, 14 interactors
IntActiP75798, 1 interactor
STRINGi316385.ECDH10B_0900

Structurei

3D structure databases

ProteinModelPortaliP75798
SMRiP75798
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 292ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST198

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CJM Bacteria
COG0601 LUCA
HOGENOMiHOG000170251
InParanoidiP75798
KOiK13890
OMAiQFTFLVA
PhylomeDBiP75798

Family and domain databases

CDDicd06261 TM_PBP2, 1 hit
Gene3Di1.10.3720.10, 1 hit
InterProiView protein in InterPro
IPR000515 MetI-like
IPR035906 MetI-like_sf
PfamiView protein in Pfam
PF00528 BPD_transp_1, 1 hit
SUPFAMiSSF161098 SSF161098, 1 hit
PROSITEiView protein in PROSITE
PS50928 ABC_TM1, 1 hit

Sequencei

Sequence statusi: Complete.

P75798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNYVIKRLL GLIPTLFIVS VLVFLFVHML PGDPARLIAG PEADAQVIEL
60 70 80 90 100
VRQQLGLDQP LYHQFWHYIS NAVQGDFGLS MVSRRPVADE IASRFMPTLW
110 120 130 140 150
LTITSMVWAV IFGMAAGIIA AVWRNRWPDR LSMTIAVSGI SFPAFALGML
160 170 180 190 200
LIQVFSVELG WLPTVGADSW QHYILPSLTL GAAVAAVMAR FTRASFVDVL
210 220 230 240 250
SEDYMRTARA KGVSETWVVL KHGLRNAMIP VVTMMGLQFG FLLGGSIVVE
260 270 280 290 300
KVFNWPGLGR LLVDSVEMRD YPVIQAEILL FSLEFILINL VVDVLYAAIN

PAIRYK
Length:306
Mass (Da):34,066
Last modified:February 1, 1997 - v1
Checksum:iB74F4D9F2527AECE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73918.1
AP009048 Genomic DNA Translation: BAA35526.1
PIRiG64820
RefSeqiNP_415352.1, NC_000913.3
WP_000936043.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73918; AAC73918; b0831
BAA35526; BAA35526; BAA35526
GeneIDi945460
KEGGiecj:JW0815
eco:b0831
PATRICifig|1411691.4.peg.1447

Entry informationi

Entry nameiGSIC_ECOLI
AccessioniPrimary (citable) accession number: P75798
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health