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Protein

Glutathione transport system permease protein GsiC

Gene

gsiC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane (Probable).1 Publication

GO - Molecular functioni

  • glutathione transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • glutathione transmembrane transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:YLIC-MONOMER.
ECOL316407:JW0815-MONOMER.
MetaCyc:YLIC-MONOMER.

Protein family/group databases

TCDBi3.A.1.5.11. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione transport system permease protein GsiC
Gene namesi
Name:gsiC
Synonyms:yliC
Ordered Locus Names:b0831, JW0815
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13474. gsiC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence analysis
Transmembranei9 – 2921HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini30 – 10273PeriplasmicSequence analysisAdd
BLAST
Transmembranei103 – 12321HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini124 – 13411CytoplasmicSequence analysisAdd
BLAST
Transmembranei135 – 15521HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini156 – 16813PeriplasmicSequence analysisAdd
BLAST
Transmembranei169 – 18921HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini190 – 22839CytoplasmicSequence analysisAdd
BLAST
Transmembranei229 – 24921HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini250 – 27728PeriplasmicSequence analysisAdd
BLAST
Transmembranei278 – 29821HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini299 – 3068CytoplasmicSequence analysis

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Glutathione transport system permease protein GsiCPRO_0000060261Add
BLAST

Proteomic databases

PaxDbiP75798.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute-binding protein (GsiB).Curated

Protein-protein interaction databases

BioGridi4259983. 3 interactions.
IntActiP75798. 1 interaction.
STRINGi511145.b0831.

Structurei

3D structure databases

ProteinModelPortaliP75798.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini95 – 292198ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CJM. Bacteria.
COG0601. LUCA.
HOGENOMiHOG000170251.
InParanoidiP75798.
KOiK13890.
OMAiDSWKHYI.
OrthoDBiEOG66F098.
PhylomeDBiP75798.

Family and domain databases

Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNYVIKRLL GLIPTLFIVS VLVFLFVHML PGDPARLIAG PEADAQVIEL
60 70 80 90 100
VRQQLGLDQP LYHQFWHYIS NAVQGDFGLS MVSRRPVADE IASRFMPTLW
110 120 130 140 150
LTITSMVWAV IFGMAAGIIA AVWRNRWPDR LSMTIAVSGI SFPAFALGML
160 170 180 190 200
LIQVFSVELG WLPTVGADSW QHYILPSLTL GAAVAAVMAR FTRASFVDVL
210 220 230 240 250
SEDYMRTARA KGVSETWVVL KHGLRNAMIP VVTMMGLQFG FLLGGSIVVE
260 270 280 290 300
KVFNWPGLGR LLVDSVEMRD YPVIQAEILL FSLEFILINL VVDVLYAAIN

PAIRYK
Length:306
Mass (Da):34,066
Last modified:February 1, 1997 - v1
Checksum:iB74F4D9F2527AECE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73918.1.
AP009048 Genomic DNA. Translation: BAA35526.1.
PIRiG64820.
RefSeqiNP_415352.1. NC_000913.3.
WP_000936043.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73918; AAC73918; b0831.
BAA35526; BAA35526; BAA35526.
GeneIDi945460.
KEGGiecj:JW0815.
eco:b0831.
PATRICi32116865. VBIEscCol129921_0858.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73918.1.
AP009048 Genomic DNA. Translation: BAA35526.1.
PIRiG64820.
RefSeqiNP_415352.1. NC_000913.3.
WP_000936043.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP75798.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259983. 3 interactions.
IntActiP75798. 1 interaction.
STRINGi511145.b0831.

Protein family/group databases

TCDBi3.A.1.5.11. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP75798.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73918; AAC73918; b0831.
BAA35526; BAA35526; BAA35526.
GeneIDi945460.
KEGGiecj:JW0815.
eco:b0831.
PATRICi32116865. VBIEscCol129921_0858.

Organism-specific databases

EchoBASEiEB3247.
EcoGeneiEG13474. gsiC.

Phylogenomic databases

eggNOGiENOG4105CJM. Bacteria.
COG0601. LUCA.
HOGENOMiHOG000170251.
InParanoidiP75798.
KOiK13890.
OMAiDSWKHYI.
OrthoDBiEOG66F098.
PhylomeDBiP75798.

Enzyme and pathway databases

BioCyciEcoCyc:YLIC-MONOMER.
ECOL316407:JW0815-MONOMER.
MetaCyc:YLIC-MONOMER.

Miscellaneous databases

PROiP75798.

Family and domain databases

Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette."
    Suzuki H., Koyanagi T., Izuka S., Onishi A., Kumagai H.
    J. Bacteriol. 187:5861-5867(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN GLUTATHIONE TRANSPORT.
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiGSIC_ECOLI
AccessioniPrimary (citable) accession number: P75798
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: January 20, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.