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Protein

Moderate conductance mechanosensitive channel YbiO

Gene

ybiO

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G6417-MONOMER.
ECOL316407:JW5108-MONOMER.

Protein family/group databases

TCDBi1.A.23.3.2. the small conductance mechanosensitive ion channel (mscs) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Moderate conductance mechanosensitive channel YbiO
Gene namesi
Name:ybiO
Ordered Locus Names:b0808, JW5108
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13320. ybiO.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei143 – 16321HelicalSequence analysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence analysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence analysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence analysisAdd
BLAST
Transmembranei294 – 31421HelicalSequence analysisAdd
BLAST
Transmembranei343 – 36321HelicalSequence analysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence analysisAdd
BLAST
Transmembranei432 – 45221HelicalSequence analysisAdd
BLAST
Transmembranei466 – 48621HelicalSequence analysisAdd
BLAST
Transmembranei509 – 52921HelicalSequence analysisAdd
BLAST
Transmembranei533 – 55321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 741723Moderate conductance mechanosensitive channel YbiOPRO_0000110241Add
BLAST

Proteomic databases

PaxDbiP75783.
PRIDEiP75783.

Expressioni

Inductioni

Induced by NaCl and RpoS.1 Publication

Interactioni

Subunit structurei

Homoheptamer.1 Publication

Protein-protein interaction databases

BioGridi4260824. 248 interactions.
DIPiDIP-11435N.
STRINGi511145.b0808.

Structurei

3D structure databases

ProteinModelPortaliP75783.
SMRiP75783. Positions 501-716.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 306Poly-Thr
Compositional biasi195 – 2028Poly-Leu

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D8X. Bacteria.
COG0668. LUCA.
HOGENOMiHOG000118144.
InParanoidiP75783.
OMAiLHNGAGE.
OrthoDBiEOG67X1VV.
PhylomeDBiP75783.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR011066. MscC_channel_C.
IPR006685. MscS_channel.
IPR011014. MscS_channel_TM-2.
[Graphical view]
PfamiPF00924. MS_channel. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
SSF82689. SSF82689. 1 hit.
SSF82861. SSF82861. 1 hit.
PROSITEiPS01246. UPF0003. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P75783-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWILFILFC LLGAPAHAVS IPGVTTTTTT DSTTEPAPEP DIEQKKAAYG
60 70 80 90 100
ALADVLDNDT SRKELIDQLR TVAATPPAEP VPKIVPPTLV EEQTVLQKVT
110 120 130 140 150
EVSRHYGEAL SARFGQLYRN ITGSPHKPFN PQTFSNALTH FSMLAVLVFG
160 170 180 190 200
FYWLIRLCAL PLYRKMGQWA RQKNRERSNW LQLPAMIIGA FIIDLLLLAL
210 220 230 240 250
TLFVGQVLSD NLNAGSRTIA FQQSLFLNAF ALIEFFKAVL RLIFCPNVAE
260 270 280 290 300
LRPFTIQDES ARYWSRRLSW LSSLIGYGLI VAVPIISNQV NVQIGALANV
310 320 330 340 350
IIMLCMTVWA LYLIFRNKKE ITQHLLNFAE HSLAFFSLFI RAFALVWHWL
360 370 380 390 400
ASAYFIVLFF FSLFDPGNSL KFMMGATVRS LAIIGIAAFV SGMFSRWLAK
410 420 430 440 450
TITLSPHTQR NYPELQKRLN GWLSAALKTA RILTVCVAVM LLLSAWGLFD
460 470 480 490 500
FWNWLQNGAG QKTVDILIRI ALILFFSAVG WTVLASLIEN RLASDIHGRP
510 520 530 540 550
LPSARTRTLL TLFRNALAVI ISTITIMIVL SEIGVNIAPL LAGAGALGLA
560 570 580 590 600
ISFGSQTLVK DIITGVFIQF ENGMNTGDLV TIGPLTGTVE RMSIRSVGVR
610 620 630 640 650
QDTGAYHIIP WSSITTFANF VRGIGSVVAN YDVDRHEDAD KANQALKDAV
660 670 680 690 700
AELMENEEIR GLIIGEPNFA GIVGLSNTAF TLRVSFTTLP LKQWTVRFAL
710 720 730 740
DSQVKKHFDL AGVRAPVQTY QVLPAPGATP AEPLPPGEPT L
Length:741
Mass (Da):81,904
Last modified:December 15, 1998 - v2
Checksum:i69B0A27678976DB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73895.2.
AP009048 Genomic DNA. Translation: BAA35474.2.
PIRiH64817.
RefSeqiNP_415329.4. NC_000913.3.
WP_001267253.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73895; AAC73895; b0808.
BAA35474; BAA35474; BAA35474.
GeneIDi945935.
KEGGiecj:JW5108.
eco:b0808.
PATRICi32116819. VBIEscCol129921_0835.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73895.2.
AP009048 Genomic DNA. Translation: BAA35474.2.
PIRiH64817.
RefSeqiNP_415329.4. NC_000913.3.
WP_001267253.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP75783.
SMRiP75783. Positions 501-716.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260824. 248 interactions.
DIPiDIP-11435N.
STRINGi511145.b0808.

Protein family/group databases

TCDBi1.A.23.3.2. the small conductance mechanosensitive ion channel (mscs) family.

Proteomic databases

PaxDbiP75783.
PRIDEiP75783.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73895; AAC73895; b0808.
BAA35474; BAA35474; BAA35474.
GeneIDi945935.
KEGGiecj:JW5108.
eco:b0808.
PATRICi32116819. VBIEscCol129921_0835.

Organism-specific databases

EchoBASEiEB3104.
EcoGeneiEG13320. ybiO.

Phylogenomic databases

eggNOGiENOG4105D8X. Bacteria.
COG0668. LUCA.
HOGENOMiHOG000118144.
InParanoidiP75783.
OMAiLHNGAGE.
OrthoDBiEOG67X1VV.
PhylomeDBiP75783.

Enzyme and pathway databases

BioCyciEcoCyc:G6417-MONOMER.
ECOL316407:JW5108-MONOMER.

Miscellaneous databases

PROiP75783.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR011066. MscC_channel_C.
IPR006685. MscS_channel.
IPR011014. MscS_channel_TM-2.
[Graphical view]
PfamiPF00924. MS_channel. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
SSF82689. SSF82689. 1 hit.
SSF82861. SSF82861. 1 hit.
PROSITEiPS01246. UPF0003. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Characterization of three novel mechanosensitive channel activities in Escherichia coli."
    Edwards M.D., Black S., Rasmussen T., Rasmussen A., Stokes N.R., Stephen T.L., Miller S., Booth I.R.
    Channels 6:272-281(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, INDUCTION.

Entry informationi

Entry nameiYBIO_ECOLI
AccessioniPrimary (citable) accession number: P75783
Secondary accession number(s): Q9R7S0, Q9R7S2, Q9ZBC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 15, 1998
Last modified: January 20, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.