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Protein

Catecholate siderophore receptor Fiu

Gene

fiu

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the active transport across the outer membrane of iron complexed with catecholate siderophores such as dihydroxybenzoylserine and dihydroxybenzoate. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB. Can also transport catechol-substituted cephalosporins. Receptor for microcins M, H47 and E492.5 Publications

GO - Molecular functioni

GO - Biological processi

  • ion transport Source: UniProtKB-KW
  • iron ion homeostasis Source: UniProtKB-KW
  • microcin transport Source: EcoliWiki
  • siderophore transport Source: EcoliWiki

Keywordsi

Molecular functionReceptor
Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

BioCyciEcoCyc:G6414-MONOMER

Protein family/group databases

TCDBi1.B.14.1.9 the outer membrane receptor (omr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Catecholate siderophore receptor Fiu
Alternative name(s):
Ferric iron uptake protein
TonB-dependent receptor Fiu
Gene namesi
Name:fiu
Synonyms:ybiL
Ordered Locus Names:b0805, JW0790
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Organism-specific databases

EcoGeneiEG13317 fiu

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000003479032 – 760Catecholate siderophore receptor FiuAdd BLAST729

Proteomic databases

PaxDbiP75780
PRIDEiP75780

Expressioni

Inductioni

Repressed by iron.3 Publications

Interactioni

Protein-protein interaction databases

BioGridi4259972, 125 interactors
DIPiDIP-11432N
IntActiP75780, 3 interactors
STRINGi316385.ECDH10B_0873

Structurei

3D structure databases

ProteinModelPortaliP75780
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi743 – 760TonB C-terminal boxAdd BLAST18

Sequence similaritiesi

Belongs to the TonB-dependent receptor family.Curated

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4108IU3 Bacteria
COG4774 LUCA
HOGENOMiHOG000130432
InParanoidiP75780
KOiK16090
OMAiTWGSDQT
PhylomeDBiP75780

Family and domain databases

Gene3Di2.170.130.10, 1 hit
2.40.170.20, 1 hit
InterProiView protein in InterPro
IPR030148 Fiu
IPR012910 Plug_dom
IPR037066 Plug_dom_sf
IPR000531 TonB-dep_rcpt_b-brl
IPR010916 TonB_box_CS
IPR036942 TonB_rcpt_b-brl_sf
IPR010105 TonB_sidphr_rcpt
PANTHERiPTHR32552:SF25 PTHR32552:SF25, 1 hit
PfamiView protein in Pfam
PF07715 Plug, 1 hit
PF00593 TonB_dep_Rec, 1 hit
TIGRFAMsiTIGR01783 TonB-siderophor, 1 hit
PROSITEiView protein in PROSITE
PS00430 TONB_DEPENDENT_REC_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P75780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENNRNFPAR QFHSLTFFAG LCIGITPVAQ ALAAEGQTNA DDTLVVEAST
60 70 80 90 100
PSLYAPQQSA DPKFSRPVAD TTRTMTVISE QVIKDQGATN LTDALKNVPG
110 120 130 140 150
VGAFFAGENG NSTTGDAIYM RGADTSNSIY IDGIRDIGSV SRDTFNTEQV
160 170 180 190 200
EVIKGPSGTD YGRSAPTGSI NMISKQPRND SGIDASASIG SAWFRRGTLD
210 220 230 240 250
VNQVIGDTTA VRLNVMGEKT HDAGRDKVKN ERYGVAPSVA FGLGTANRLY
260 270 280 290 300
LNYLHVTQHN TPDGGIPTIG LPGYSAPSAG TAALNHSGKV DTHNFYGTDS
310 320 330 340 350
DYDDSTTDTA TMRFEHDIND NTTIRNTTRW SRVKQDYLMT AIMGGASNIT
360 370 380 390 400
QPTSDVNSWT WSRTANTKDV SNKILTNQTN LTSTFYTGSI GHDVSTGVEF
410 420 430 440 450
TRETQTNYGV NPVTLPAVNI YHPDSSIHPG GLTRNGANAN GQTDTFAIYA
460 470 480 490 500
FDTLQITRDF ELNGGIRLDN YHTEYDSATA CGGSGRGAIT CPTGVAKGSP
510 520 530 540 550
VTTVDTAKSG NLMNWKAGAL YHLTENGNVY INYAVSQQPP GGNNFALAQS
560 570 580 590 600
GSGNSANRTD FKPQKANTSE IGTKWQVLDK RLLLTAALFR TDIENEVEQN
610 620 630 640 650
DDGTYSQYGK KRVEGYEISV AGNITPAWQV IGGYTQQKAT IKNGKDVAQD
660 670 680 690 700
GSSSLPYTPE HAFTLWSQYQ ATDDISVGAG ARYIGSMHKG SDGAVGTPAF
710 720 730 740 750
TEGYWVADAK LGYRVNRNLD FQLNVYNLFD TDYVASINKS GYRYHPGEPR
760
TFLLTANMHF
Length:760
Mass (Da):81,960
Last modified:February 1, 1997 - v1
Checksum:i1B66B9C2EF68C7CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73892.1
AP009048 Genomic DNA Translation: BAA35471.1
PIRiE64817
RefSeqiNP_415326.1, NC_000913.3
WP_000430057.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73892; AAC73892; b0805
BAA35471; BAA35471; BAA35471
GeneIDi946246
KEGGiecj:JW0790
eco:b0805
PATRICifig|1411691.4.peg.1473

Entry informationi

Entry nameiFIU_ECOLI
AccessioniPrimary (citable) accession number: P75780
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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