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Protein

Zinc transporter ZitB

Gene

zitB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc, whereas ZntA is required for growth at more toxic concentrations.

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • regulation of sequestering of zinc ion Source: GO_Central
  • response to zinc ion Source: GO_Central
  • zinc II ion transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

BioCyciEcoCyc:B0752-MONOMER.
ECOL316407:JW0735-MONOMER.
MetaCyc:B0752-MONOMER.

Protein family/group databases

TCDBi2.A.4.1.4. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZitB
Gene namesi
Name:zitB
Synonyms:ybgR
Ordered Locus Names:b0752, JW0735
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13662. zitB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Topological domaini42 – 47PeriplasmicSequence analysis6
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 89CytoplasmicSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111 – 121PeriplasmicSequence analysisAdd BLAST11
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 159CytoplasmicSequence analysisAdd BLAST17
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181PeriplasmicSequence analysis1
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 313CytoplasmicSequence analysisAdd BLAST111

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002061071 – 313Zinc transporter ZitBAdd BLAST313

Proteomic databases

PaxDbiP75757.
PRIDEiP75757.

Expressioni

Inductioni

By zinc.

Interactioni

Protein-protein interaction databases

BioGridi4261706. 25 interactors.
STRINGi511145.b0752.

Structurei

3D structure databases

ProteinModelPortaliP75757.
SMRiP75757.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi240 – 313His-richAdd BLAST74

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105PGM. Bacteria.
COG1230. LUCA.
HOGENOMiHOG000079021.
InParanoidiP75757.
KOiK16264.
OMAiYFHHVEH.
PhylomeDBiP75757.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
3.30.70.1350. 1 hit.
HAMAPiMF_00552. ZitB. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027470. Cation_efflux_CTD.
IPR027469. Cation_efflux_TMD.
IPR023500. Zn_transptr_ZitB.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

P75757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHSHSHTSS HLPEDNNARR LLYAFGVTAG FMLVEVVGGF LSGSLALLAD
60 70 80 90 100
AGHMLTDTAA LLFALLAVQF SRRPPTIRHT FGWLRLTTLA AFVNAIALVV
110 120 130 140 150
ITILIVWEAI ERFRTPRPVE GGMMMAIAVA GLLANILSFW LLHHGSEEKN
160 170 180 190 200
LNVRAAALHV LGDLLGSVGA IIAALIIIWT GWTPADPILS ILVSLLVLRS
210 220 230 240 250
AWRLLKDSVN ELLEGAPVSL DIAELKRRMC REIPEVRNVH HVHVWMVGEK
260 270 280 290 300
PVMTLHVQVI PPHDHDALLD QIQHYLMDHY QIEHATIQME YQPCHGPDCH
310
LNEGVSGHSH HHH
Length:313
Mass (Da):34,678
Last modified:February 1, 1997 - v1
Checksum:i36740D67EABAC907
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73839.1.
AP009048 Genomic DNA. Translation: BAA35414.1.
PIRiH64810.
RefSeqiNP_415273.1. NC_000913.3.
WP_000951292.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73839; AAC73839; b0752.
BAA35414; BAA35414; BAA35414.
GeneIDi945348.
KEGGiecj:JW0735.
eco:b0752.
PATRICi32116703. VBIEscCol129921_0777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73839.1.
AP009048 Genomic DNA. Translation: BAA35414.1.
PIRiH64810.
RefSeqiNP_415273.1. NC_000913.3.
WP_000951292.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP75757.
SMRiP75757.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261706. 25 interactors.
STRINGi511145.b0752.

Protein family/group databases

TCDBi2.A.4.1.4. the cation diffusion facilitator (cdf) family.

Proteomic databases

PaxDbiP75757.
PRIDEiP75757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73839; AAC73839; b0752.
BAA35414; BAA35414; BAA35414.
GeneIDi945348.
KEGGiecj:JW0735.
eco:b0752.
PATRICi32116703. VBIEscCol129921_0777.

Organism-specific databases

EchoBASEiEB3426.
EcoGeneiEG13662. zitB.

Phylogenomic databases

eggNOGiENOG4105PGM. Bacteria.
COG1230. LUCA.
HOGENOMiHOG000079021.
InParanoidiP75757.
KOiK16264.
OMAiYFHHVEH.
PhylomeDBiP75757.

Enzyme and pathway databases

BioCyciEcoCyc:B0752-MONOMER.
ECOL316407:JW0735-MONOMER.
MetaCyc:B0752-MONOMER.

Miscellaneous databases

PROiP75757.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
3.30.70.1350. 1 hit.
HAMAPiMF_00552. ZitB. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027470. Cation_efflux_CTD.
IPR027469. Cation_efflux_TMD.
IPR023500. Zn_transptr_ZitB.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZITB_ECOLI
AccessioniPrimary (citable) accession number: P75757
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Appears to be selective for zinc, not conferring resistance to cobalt nor cadmium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.