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Protein

Zinc transporter ZitB

Gene

zitB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc, whereas ZntA is required for growth at more toxic concentrations.

Miscellaneous

Appears to be selective for zinc, not conferring resistance to cobalt nor cadmium.

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • zinc II ion transport Source: EcoCyc

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

BioCyciEcoCyc:B0752-MONOMER
MetaCyc:B0752-MONOMER

Protein family/group databases

TCDBi2.A.4.1.4 the cation diffusion facilitator (cdf) family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZitB
Gene namesi
Name:zitB
Synonyms:ybgR
Ordered Locus Names:b0752, JW0735
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13662 zitB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Topological domaini42 – 47PeriplasmicSequence analysis6
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 89CytoplasmicSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111 – 121PeriplasmicSequence analysisAdd BLAST11
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 159CytoplasmicSequence analysisAdd BLAST17
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181PeriplasmicSequence analysis1
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 313CytoplasmicSequence analysisAdd BLAST111

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002061071 – 313Zinc transporter ZitBAdd BLAST313

Proteomic databases

PaxDbiP75757
PRIDEiP75757

Expressioni

Inductioni

By zinc.

Interactioni

Protein-protein interaction databases

BioGridi4261706, 29 interactors
STRINGi316385.ECDH10B_0819

Structurei

3D structure databases

ProteinModelPortaliP75757
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi240 – 313His-richAdd BLAST74

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105PGM Bacteria
COG1230 LUCA
HOGENOMiHOG000079021
InParanoidiP75757
KOiK16264
OMAiSEDMKDC
PhylomeDBiP75757

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
HAMAPiMF_00552 ZitB, 1 hit
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR036837 Cation_efflux_CTD_sf
IPR027469 Cation_efflux_TMD_sf
IPR023500 Zn_transptr_ZitB
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF160240 SSF160240, 1 hit
SSF161111 SSF161111, 1 hit
TIGRFAMsiTIGR01297 CDF, 1 hit

Sequencei

Sequence statusi: Complete.

P75757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHSHSHTSS HLPEDNNARR LLYAFGVTAG FMLVEVVGGF LSGSLALLAD
60 70 80 90 100
AGHMLTDTAA LLFALLAVQF SRRPPTIRHT FGWLRLTTLA AFVNAIALVV
110 120 130 140 150
ITILIVWEAI ERFRTPRPVE GGMMMAIAVA GLLANILSFW LLHHGSEEKN
160 170 180 190 200
LNVRAAALHV LGDLLGSVGA IIAALIIIWT GWTPADPILS ILVSLLVLRS
210 220 230 240 250
AWRLLKDSVN ELLEGAPVSL DIAELKRRMC REIPEVRNVH HVHVWMVGEK
260 270 280 290 300
PVMTLHVQVI PPHDHDALLD QIQHYLMDHY QIEHATIQME YQPCHGPDCH
310
LNEGVSGHSH HHH
Length:313
Mass (Da):34,678
Last modified:February 1, 1997 - v1
Checksum:i36740D67EABAC907
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73839.1
AP009048 Genomic DNA Translation: BAA35414.1
PIRiH64810
RefSeqiNP_415273.1, NC_000913.3
WP_000951292.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73839; AAC73839; b0752
BAA35414; BAA35414; BAA35414
GeneIDi945348
KEGGiecj:JW0735
eco:b0752
PATRICifig|1411691.4.peg.1527

Similar proteinsi

Entry informationi

Entry nameiZITB_ECOLI
AccessioniPrimary (citable) accession number: P75757
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health