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Protein

Dipeptide permease D

Gene

dtpD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable proton-dependent permease that transports dipeptides.By similarity

GO - Molecular functioni

  • dipeptide transporter activity Source: EcoCyc
  • peptide:proton symporter activity Source: UniProtKB-HAMAP

GO - Biological processi

  • dipeptide transport Source: EcoCyc
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:B0709-MONOMER.
ECOL316407:JW0699-MONOMER.
MetaCyc:B0709-MONOMER.

Protein family/group databases

TCDBi2.A.17.1.4. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptide permease D
Gene namesi
Name:dtpD
Synonyms:ybgH
Ordered Locus Names:b0709, JW0699
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13304. dtpD.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 48PeriplasmicSequence analysisAdd BLAST14
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 77CytoplasmicSequence analysis8
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 100PeriplasmicSequence analysis2
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 137CytoplasmicSequence analysisAdd BLAST16
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 166PeriplasmicSequence analysis8
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 211CytoplasmicSequence analysisAdd BLAST24
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Topological domaini233 – 234PeriplasmicSequence analysis2
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 266CytoplasmicSequence analysisAdd BLAST11
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 311PeriplasmicSequence analysisAdd BLAST24
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 343CytoplasmicSequence analysisAdd BLAST11
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 378PeriplasmicSequence analysisAdd BLAST14
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 412CytoplasmicSequence analysisAdd BLAST13
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 461PeriplasmicSequence analysisAdd BLAST28
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 493CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • integral component of plasma membrane Source: UniProtKB-HAMAP
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643281 – 493Dipeptide permease DAdd BLAST493

Proteomic databases

PaxDbiP75742.
PRIDEiP75742.

Interactioni

Protein-protein interaction databases

BioGridi4263335. 112 interactors.
DIPiDIP-11394N.
IntActiP75742. 2 interactors.
MINTiMINT-1290177.
STRINGi511145.b0709.

Structurei

Secondary structure

1493
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 38Combined sources30
Beta strandi39 – 41Combined sources3
Helixi44 – 60Combined sources17
Helixi62 – 71Combined sources10
Helixi77 – 92Combined sources16
Turni99 – 101Combined sources3
Helixi102 – 126Combined sources25
Helixi135 – 162Combined sources28
Turni163 – 165Combined sources3
Helixi167 – 186Combined sources20
Beta strandi207 – 209Combined sources3
Helixi212 – 232Combined sources21
Helixi234 – 254Combined sources21
Helixi267 – 297Combined sources31
Helixi310 – 313Combined sources4
Helixi314 – 331Combined sources18
Helixi342 – 369Combined sources28
Helixi379 – 393Combined sources15
Beta strandi394 – 396Combined sources3
Helixi397 – 403Combined sources7
Helixi411 – 437Combined sources27
Helixi452 – 480Combined sources29

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q65X-ray3.40A1-493[»]
ProteinModelPortaliP75742.
SMRiP75742.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DUX. Bacteria.
COG3104. LUCA.
HOGENOMiHOG000243450.
InParanoidiP75742.
KOiK03305.
OMAiAWLIKES.
PhylomeDBiP75742.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01880. PTR2_DtpD_subfam. 1 hit.
InterProiIPR023777. AA/pep_transptr_DtpD.
IPR005279. Dipep/tripep_permease.
IPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00924. yjdL_sub1_fam. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75742-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKHASQPRA IYYVVALQIW EYFSFYGMRA LLILYLTNQL KYNDTHAYEL
60 70 80 90 100
FSAYCSLVYV TPILGGFLAD KVLGNRMAVM LGALLMAIGH VVLGASEIHP
110 120 130 140 150
SFLYLSLAII VCGYGLFKSN VSCLLGELYE PTDPRRDGGF SLMYAAGNVG
160 170 180 190 200
SIIAPIACGY AQEEYSWAMG FGLAAVGMIA GLVIFLCGNR HFTHTRGVNK
210 220 230 240 250
KVLRATNFLL PNWGWLLVLL VATPALITIL FWKEWSVYAL IVATIIGLGV
260 270 280 290 300
LAKIYRKAEN QKQRKELGLI VTLTFFSMLF WAFAQQGGSS ISLYIDRFVN
310 320 330 340 350
RDMFGYTVPT AMFQSINAFA VMLCGVFLAW VVKESVAGNR TVRIWGKFAL
360 370 380 390 400
GLGLMSAGFC ILTLSARWSA MYGHSSLPLM VLGLAVMGFA ELFIDPVAMS
410 420 430 440 450
QITRIEIPGV TGVLTGIYML LSGAIANYLA GVIADQTSQA SFDASGAINY
460 470 480 490
SINAYIEVFD QITWGALACV GLVLMIWLYQ ALKFRNRALA LES
Length:493
Mass (Da):54,159
Last modified:February 1, 1997 - v1
Checksum:i930DB6EDAE448B7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73803.1.
AP009048 Genomic DNA. Translation: BAA35368.1.
PIRiD64806.
RefSeqiNP_415237.1. NC_000913.3.
WP_001032689.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73803; AAC73803; b0709.
BAA35368; BAA35368; BAA35368.
GeneIDi947368.
KEGGiecj:JW0699.
eco:b0709.
PATRICi32116613. VBIEscCol129921_0739.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73803.1.
AP009048 Genomic DNA. Translation: BAA35368.1.
PIRiD64806.
RefSeqiNP_415237.1. NC_000913.3.
WP_001032689.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q65X-ray3.40A1-493[»]
ProteinModelPortaliP75742.
SMRiP75742.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263335. 112 interactors.
DIPiDIP-11394N.
IntActiP75742. 2 interactors.
MINTiMINT-1290177.
STRINGi511145.b0709.

Protein family/group databases

TCDBi2.A.17.1.4. the proton-dependent oligopeptide transporter (pot/ptr) family.

Proteomic databases

PaxDbiP75742.
PRIDEiP75742.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73803; AAC73803; b0709.
BAA35368; BAA35368; BAA35368.
GeneIDi947368.
KEGGiecj:JW0699.
eco:b0709.
PATRICi32116613. VBIEscCol129921_0739.

Organism-specific databases

EchoBASEiEB3088.
EcoGeneiEG13304. dtpD.

Phylogenomic databases

eggNOGiENOG4105DUX. Bacteria.
COG3104. LUCA.
HOGENOMiHOG000243450.
InParanoidiP75742.
KOiK03305.
OMAiAWLIKES.
PhylomeDBiP75742.

Enzyme and pathway databases

BioCyciEcoCyc:B0709-MONOMER.
ECOL316407:JW0699-MONOMER.
MetaCyc:B0709-MONOMER.

Miscellaneous databases

PROiP75742.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01880. PTR2_DtpD_subfam. 1 hit.
InterProiIPR023777. AA/pep_transptr_DtpD.
IPR005279. Dipep/tripep_permease.
IPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00924. yjdL_sub1_fam. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDTPD_ECOLI
AccessioniPrimary (citable) accession number: P75742
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.