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Protein

Dipeptide permease D

Gene

dtpD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable proton-dependent permease that transports dipeptides.By similarity

GO - Molecular functioni

  • dipeptide transporter activity Source: EcoCyc
  • peptide:proton symporter activity Source: UniProtKB-HAMAP

GO - Biological processi

  • dipeptide transport Source: EcoCyc
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:B0709-MONOMER.
ECOL316407:JW0699-MONOMER.
MetaCyc:B0709-MONOMER.

Protein family/group databases

TCDBi2.A.17.1.4. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptide permease D
Gene namesi
Name:dtpD
Synonyms:ybgH
Ordered Locus Names:b0709, JW0699
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13304. dtpD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence analysisAdd
BLAST
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Topological domaini35 – 4814PeriplasmicSequence analysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence analysisAdd
BLAST
Topological domaini70 – 778CytoplasmicSequence analysis
Transmembranei78 – 9821HelicalSequence analysisAdd
BLAST
Topological domaini99 – 1002PeriplasmicSequence analysis
Transmembranei101 – 12121HelicalSequence analysisAdd
BLAST
Topological domaini122 – 13716CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence analysisAdd
BLAST
Topological domaini159 – 1668PeriplasmicSequence analysis
Transmembranei167 – 18721HelicalSequence analysisAdd
BLAST
Topological domaini188 – 21124CytoplasmicSequence analysisAdd
BLAST
Transmembranei212 – 23221HelicalSequence analysisAdd
BLAST
Topological domaini233 – 2342PeriplasmicSequence analysis
Transmembranei235 – 25521HelicalSequence analysisAdd
BLAST
Topological domaini256 – 26611CytoplasmicSequence analysisAdd
BLAST
Transmembranei267 – 28721HelicalSequence analysisAdd
BLAST
Topological domaini288 – 31124PeriplasmicSequence analysisAdd
BLAST
Transmembranei312 – 33221HelicalSequence analysisAdd
BLAST
Topological domaini333 – 34311CytoplasmicSequence analysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence analysisAdd
BLAST
Topological domaini365 – 37814PeriplasmicSequence analysisAdd
BLAST
Transmembranei379 – 39921HelicalSequence analysisAdd
BLAST
Topological domaini400 – 41213CytoplasmicSequence analysisAdd
BLAST
Transmembranei413 – 43321HelicalSequence analysisAdd
BLAST
Topological domaini434 – 46128PeriplasmicSequence analysisAdd
BLAST
Transmembranei462 – 48221HelicalSequence analysisAdd
BLAST
Topological domaini483 – 49311CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • integral component of plasma membrane Source: UniProtKB-HAMAP
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Dipeptide permease DPRO_0000064328Add
BLAST

Proteomic databases

PaxDbiP75742.
PRIDEiP75742.

Interactioni

Protein-protein interaction databases

BioGridi4263335. 112 interactions.
DIPiDIP-11394N.
IntActiP75742. 2 interactions.
MINTiMINT-1290177.
STRINGi511145.b0709.

Structurei

Secondary structure

1
493
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 3830Combined sources
Beta strandi39 – 413Combined sources
Helixi44 – 6017Combined sources
Helixi62 – 7110Combined sources
Helixi77 – 9216Combined sources
Turni99 – 1013Combined sources
Helixi102 – 12625Combined sources
Helixi135 – 16228Combined sources
Turni163 – 1653Combined sources
Helixi167 – 18620Combined sources
Beta strandi207 – 2093Combined sources
Helixi212 – 23221Combined sources
Helixi234 – 25421Combined sources
Helixi267 – 29731Combined sources
Helixi310 – 3134Combined sources
Helixi314 – 33118Combined sources
Helixi342 – 36928Combined sources
Helixi379 – 39315Combined sources
Beta strandi394 – 3963Combined sources
Helixi397 – 4037Combined sources
Helixi411 – 43727Combined sources
Helixi452 – 48029Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4Q65X-ray3.40A1-493[»]
ProteinModelPortaliP75742.
SMRiP75742. Positions 6-481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DUX. Bacteria.
COG3104. LUCA.
HOGENOMiHOG000243450.
InParanoidiP75742.
KOiK03305.
OMAiAWLIKES.
OrthoDBiEOG6QP0WR.
PhylomeDBiP75742.

Family and domain databases

HAMAPiMF_01880. PTR2_DtpD_subfam.
InterProiIPR023777. AA/pep_transptr_DtpD.
IPR005279. Dipep/tripep_permease.
IPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00924. yjdL_sub1_fam. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75742-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKHASQPRA IYYVVALQIW EYFSFYGMRA LLILYLTNQL KYNDTHAYEL
60 70 80 90 100
FSAYCSLVYV TPILGGFLAD KVLGNRMAVM LGALLMAIGH VVLGASEIHP
110 120 130 140 150
SFLYLSLAII VCGYGLFKSN VSCLLGELYE PTDPRRDGGF SLMYAAGNVG
160 170 180 190 200
SIIAPIACGY AQEEYSWAMG FGLAAVGMIA GLVIFLCGNR HFTHTRGVNK
210 220 230 240 250
KVLRATNFLL PNWGWLLVLL VATPALITIL FWKEWSVYAL IVATIIGLGV
260 270 280 290 300
LAKIYRKAEN QKQRKELGLI VTLTFFSMLF WAFAQQGGSS ISLYIDRFVN
310 320 330 340 350
RDMFGYTVPT AMFQSINAFA VMLCGVFLAW VVKESVAGNR TVRIWGKFAL
360 370 380 390 400
GLGLMSAGFC ILTLSARWSA MYGHSSLPLM VLGLAVMGFA ELFIDPVAMS
410 420 430 440 450
QITRIEIPGV TGVLTGIYML LSGAIANYLA GVIADQTSQA SFDASGAINY
460 470 480 490
SINAYIEVFD QITWGALACV GLVLMIWLYQ ALKFRNRALA LES
Length:493
Mass (Da):54,159
Last modified:February 1, 1997 - v1
Checksum:i930DB6EDAE448B7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73803.1.
AP009048 Genomic DNA. Translation: BAA35368.1.
PIRiD64806.
RefSeqiNP_415237.1. NC_000913.3.
WP_001032689.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73803; AAC73803; b0709.
BAA35368; BAA35368; BAA35368.
GeneIDi947368.
KEGGiecj:JW0699.
eco:b0709.
PATRICi32116613. VBIEscCol129921_0739.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73803.1.
AP009048 Genomic DNA. Translation: BAA35368.1.
PIRiD64806.
RefSeqiNP_415237.1. NC_000913.3.
WP_001032689.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4Q65X-ray3.40A1-493[»]
ProteinModelPortaliP75742.
SMRiP75742. Positions 6-481.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263335. 112 interactions.
DIPiDIP-11394N.
IntActiP75742. 2 interactions.
MINTiMINT-1290177.
STRINGi511145.b0709.

Protein family/group databases

TCDBi2.A.17.1.4. the proton-dependent oligopeptide transporter (pot/ptr) family.

Proteomic databases

PaxDbiP75742.
PRIDEiP75742.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73803; AAC73803; b0709.
BAA35368; BAA35368; BAA35368.
GeneIDi947368.
KEGGiecj:JW0699.
eco:b0709.
PATRICi32116613. VBIEscCol129921_0739.

Organism-specific databases

EchoBASEiEB3088.
EcoGeneiEG13304. dtpD.

Phylogenomic databases

eggNOGiENOG4105DUX. Bacteria.
COG3104. LUCA.
HOGENOMiHOG000243450.
InParanoidiP75742.
KOiK03305.
OMAiAWLIKES.
OrthoDBiEOG6QP0WR.
PhylomeDBiP75742.

Enzyme and pathway databases

BioCyciEcoCyc:B0709-MONOMER.
ECOL316407:JW0699-MONOMER.
MetaCyc:B0709-MONOMER.

Miscellaneous databases

PROiP75742.

Family and domain databases

HAMAPiMF_01880. PTR2_DtpD_subfam.
InterProiIPR023777. AA/pep_transptr_DtpD.
IPR005279. Dipep/tripep_permease.
IPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00924. yjdL_sub1_fam. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiDTPD_ECOLI
AccessioniPrimary (citable) accession number: P75742
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 20, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.