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Protein

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase

Gene

ubiF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Oxygenase that introduces the hydroxyl group at carbon five of 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol.

Cofactori

FADCurated

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • ubiquinone biosynthetic process Source: EcoCyc

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processUbiquinone biosynthesis
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciEcoCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-MON
MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-MON
BRENDAi1.14.99.B4 2026
UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase (EC:1.14.13.-)
Gene namesi
Name:ubiF
Synonyms:yleB
Ordered Locus Names:b0662, JW0659
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13658 ubiF

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075871 – 3912-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylaseAdd BLAST391

Proteomic databases

PaxDbiP75728
PRIDEiP75728

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi4261231, 299 interactors
DIPiDIP-11069N
IntActiP75728, 12 interactors
STRINGi316385.ECDH10B_0731

Structurei

3D structure databases

ProteinModelPortaliP75728
SMRiP75728
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiH/COQ6 family.Curated

Phylogenomic databases

eggNOGiENOG4105EAK Bacteria
COG0654 LUCA
HOGENOMiHOG000255771
InParanoidiP75728
KOiK03184
OMAiPELGYMV
PhylomeDBiP75728

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR002938 FAD-bd
IPR036188 FAD/NAD-bd_sf
IPR018168 Ubi_Hdrlase_CS
IPR010971 UbiH/COQ6
PfamiView protein in Pfam
PF01494 FAD_binding_3, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01988 Ubi-OHases, 1 hit
PROSITEiView protein in PROSITE
PS01304 UBIH, 1 hit

Sequencei

Sequence statusi: Complete.

P75728-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNQPTEIAI VGGGMVGGAL ALGLAQHGFA VTVIEHAEPA PFVADSQPDV
60 70 80 90 100
RISAISAASV SLLKGLGVWD AVQAMRCHPY RRLETWEWET AHVVFDAAEL
110 120 130 140 150
KLPLLGYMVE NTVLQQALWQ ALEAHPKVTL RVPGSLIALH RHDDLQELEL
160 170 180 190 200
KGGEVIRAKL VIGADGANSQ VRQMAGIGVH AWQYAQSCML ISVQCENDPG
210 220 230 240 250
DSTWQQFTPD GPRAFLPLFD NWASLVWYDS PARIRQLQNM NMAQLQAEIA
260 270 280 290 300
KHFPSRLGYV TPLAAGAFPL TRRHALQYVQ PGLALVGDAA HTIHPLAGQG
310 320 330 340 350
VNLGYRDVDA LIDVLVNARS YGEAWASYPV LKRYQMRRMA DNFIMQSGMD
360 370 380 390
LFYAGFSNNL PPLRFMRNLG LMAAERAGVL KRQALKYALG L
Length:391
Mass (Da):42,953
Last modified:February 1, 1997 - v1
Checksum:i05325684AAB6D30A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73763.1
AP009048 Genomic DNA Translation: BAA35316.1
U82598 Genomic DNA Translation: AAB40864.1
PIRiD64801
RefSeqiNP_415195.1, NC_000913.3
WP_000184541.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73763; AAC73763; b0662
BAA35316; BAA35316; BAA35316
GeneIDi945261
KEGGiecj:JW0659
eco:b0662
PATRICifig|1411691.4.peg.1606

Similar proteinsi

Entry informationi

Entry nameiUBIF_ECOLI
AccessioniPrimary (citable) accession number: P75728
Secondary accession number(s): P77111
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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