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Protein

Citrate lyase alpha chain

Gene

citF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Represents a citrate:acetyl-ACP transferase.By similarity

Catalytic activityi

Citrate = acetate + oxaloacetate.
Acetyl-CoA + citrate = acetate + (3S)-citryl-CoA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase, Transferase

Enzyme and pathway databases

BioCyciEcoCyc:CITTRANS-MONOMER.
ECOL316407:JW5087-MONOMER.
MetaCyc:CITTRANS-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate lyase alpha chain (EC:4.1.3.6)
Short name:
Citrase alpha chain
Alternative name(s):
Citrate (pro-3S)-lyase alpha chain
Citrate CoA-transferase subunit (EC:2.8.3.10)
Gene namesi
Name:citF
Synonyms:ybdV
Ordered Locus Names:b0615, JW5087
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13541. citF.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000897521 – 510Citrate lyase alpha chainAdd BLAST510

Proteomic databases

PaxDbiP75726.
PRIDEiP75726.

Expressioni

Inductioni

Repressed by H-NS. Part of the citCDEFXG operon.1 Publication

Interactioni

Subunit structurei

Oligomer with a subunit composition of (alpha,beta, gamma)6.By similarity

Protein-protein interaction databases

BioGridi4261998. 5 interactors.
STRINGi511145.b0615.

Structurei

3D structure databases

ProteinModelPortaliP75726.
SMRiP75726.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105CHY. Bacteria.
COG3051. LUCA.
HOGENOMiHOG000117923.
InParanoidiP75726.
KOiK01643.
OMAiKGSVINQ.
PhylomeDBiP75726.

Family and domain databases

InterProiIPR006472. Citrate_lyase_asu.
[Graphical view]
PfamiPF04223. CitF. 1 hit.
[Graphical view]
PIRSFiPIRSF009451. Citrt_lyas_alpha. 1 hit.
TIGRFAMsiTIGR01584. citF. 1 hit.

Sequencei

Sequence statusi: Complete.

P75726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQKIEQSQR QERVAAWNRR AECDLAAFQN SPKQTYQAEK ARDRKLCANL
60 70 80 90 100
EEAIRRSGLQ DGMTVSFHHA FRGGDLTVNM VMDVIAKMGF KNLTLASSSL
110 120 130 140 150
SDCHAPLVEH IRQGVVTRIY TSGLRGPLAE EISRGLLAEP VQIHSHGGRV
160 170 180 190 200
HLVQSGELNI DVAFLGVPSC DEFGNANGYT GKACCGSLGY AIVDADNAKQ
210 220 230 240 250
VVMLTEELLP YPHNPASIEQ DQVDLIVKVD RVGDAAKIGA GATRMTTNPR
260 270 280 290 300
ELLIARSAAD VIVNSGYFKE GFSMQTGTGG ASLAVTRFLE DKMRSRDIRA
310 320 330 340 350
DFALGGITAT MVDLHEKGLI RKLLDVQSFD SHAAQSLARN PNHIEISANQ
360 370 380 390 400
YANWGSKGAS VDRLDVVVLS ALEIDTQFNV NVLTGSDGVL RGASGGHCDT
410 420 430 440 450
AIASALSIIV APLVRGRIPT LVDNVLTCIT PGSSVDILVT DHGIAVNPAR
460 470 480 490 500
PELAERLQEA GIKVVSIEWL RERARLLTGE PQPIEFTDRV VAVVRYRDGS
510
VIDVVHQVKE
Length:510
Mass (Da):55,173
Last modified:February 1, 1997 - v1
Checksum:iCA466F1620D8EB92
GO

Sequence cautioni

The sequence AAB40815 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40815.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73716.1.
AP009048 Genomic DNA. Translation: BAA35251.2.
PIRiE64795.
RefSeqiNP_415148.1. NC_000913.3.
WP_000192242.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73716; AAC73716; b0615.
BAA35251; BAA35251; BAA35251.
GeneIDi945230.
KEGGiecj:JW5087.
eco:b0615.
PATRICi32116410. VBIEscCol129921_0645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40815.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73716.1.
AP009048 Genomic DNA. Translation: BAA35251.2.
PIRiE64795.
RefSeqiNP_415148.1. NC_000913.3.
WP_000192242.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP75726.
SMRiP75726.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261998. 5 interactors.
STRINGi511145.b0615.

Proteomic databases

PaxDbiP75726.
PRIDEiP75726.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73716; AAC73716; b0615.
BAA35251; BAA35251; BAA35251.
GeneIDi945230.
KEGGiecj:JW5087.
eco:b0615.
PATRICi32116410. VBIEscCol129921_0645.

Organism-specific databases

EchoBASEiEB3311.
EcoGeneiEG13541. citF.

Phylogenomic databases

eggNOGiENOG4105CHY. Bacteria.
COG3051. LUCA.
HOGENOMiHOG000117923.
InParanoidiP75726.
KOiK01643.
OMAiKGSVINQ.
PhylomeDBiP75726.

Enzyme and pathway databases

BioCyciEcoCyc:CITTRANS-MONOMER.
ECOL316407:JW5087-MONOMER.
MetaCyc:CITTRANS-MONOMER.

Miscellaneous databases

PROiP75726.

Family and domain databases

InterProiIPR006472. Citrate_lyase_asu.
[Graphical view]
PfamiPF04223. CitF. 1 hit.
[Graphical view]
PIRSFiPIRSF009451. Citrt_lyas_alpha. 1 hit.
TIGRFAMsiTIGR01584. citF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCILA_ECOLI
AccessioniPrimary (citable) accession number: P75726
Secondary accession number(s): P77102, Q9R7T5, Q9R7T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.