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Protein

Uncharacterized fimbrial-like protein SfmH

Gene

sfmH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: EcoCyc
Complete GO annotation...

Keywords - Ligandi

Lectin, Mannose-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6293-MONOMER.
ECOL316407:JW5071-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized fimbrial-like protein SfmH
Gene namesi
Name:sfmH
Ordered Locus Names:b0533, JW5071
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13884. sfmH.

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Fimbrium

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 327303Uncharacterized fimbrial-like protein SfmHPRO_0000009212Add
BLAST

Proteomic databases

PaxDbiP75715.

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261686. 4 interactions.
STRINGi511145.b0533.

Structurei

3D structure databases

ProteinModelPortaliP75715.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108M66. Bacteria.
ENOG410ZUTT. LUCA.
HOGENOMiHOG000267835.
InParanoidiP75715.
KOiK07356.
OMAiQMPFGVQ.
OrthoDBiEOG69GZHZ.
PhylomeDBiP75715.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P75715-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMACLCLAN ISWATVCANS TGVAEDEHYD LSNIFNSTNN QPGQIVVLPE
60 70 80 90 100
KSGWVGVSAI CPPGTLVNYT YRSYVTNFIV QETIDNYKYM QLHDYLLGAM
110 120 130 140 150
SLVDSVMDIQ FPPQNYIRMG TDPNVSQNLP FGVMDSRLIF RLKVIRPFIN
160 170 180 190 200
MVEIPRQVMF TVYVTSTPYD PLVTPVYTIS FGGRVEVPQN CELNAGQIVE
210 220 230 240 250
FDFGDIGASL FSAAGPGNRP AGVMPQTKSI AVKCTNVAAQ AYLTMRLEAS
260 270 280 290 300
AVSGQAMVSD NQDLGFIVAD QNDTPITPND LNSVIPFRLD AAAAANVTLR
310 320
AWPISITGQK PTEGPFSALG YLRVDYQ
Length:327
Mass (Da):35,696
Last modified:June 26, 2007 - v2
Checksum:i8FAF2EA0E77A4FC5
GO

Sequence cautioni

The sequence AAB40731.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAE76310.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40731.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73635.2.
AP009048 Genomic DNA. Translation: BAE76310.1. Different initiation.
PIRiD64785.
RefSeqiNP_415066.2. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC73635; AAC73635; b0533.
BAE76310; BAE76310; BAE76310.
GeneIDi945407.
KEGGiecj:JW5071.
eco:b0533.
PATRICi32116226. VBIEscCol129921_0554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40731.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73635.2.
AP009048 Genomic DNA. Translation: BAE76310.1. Different initiation.
PIRiD64785.
RefSeqiNP_415066.2. NC_000913.3.

3D structure databases

ProteinModelPortaliP75715.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261686. 4 interactions.
STRINGi511145.b0533.

Proteomic databases

PaxDbiP75715.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73635; AAC73635; b0533.
BAE76310; BAE76310; BAE76310.
GeneIDi945407.
KEGGiecj:JW5071.
eco:b0533.
PATRICi32116226. VBIEscCol129921_0554.

Organism-specific databases

EchoBASEiEB3643.
EcoGeneiEG13884. sfmH.

Phylogenomic databases

eggNOGiENOG4108M66. Bacteria.
ENOG410ZUTT. LUCA.
HOGENOMiHOG000267835.
InParanoidiP75715.
KOiK07356.
OMAiQMPFGVQ.
OrthoDBiEOG69GZHZ.
PhylomeDBiP75715.

Enzyme and pathway databases

BioCyciEcoCyc:G6293-MONOMER.
ECOL316407:JW5071-MONOMER.

Miscellaneous databases

PROiP75715.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Escherichia coli K-12 possesses multiple cryptic but functional chaperone-usher fimbriae with distinct surface specificities."
    Korea C.G., Badouraly R., Prevost M.C., Ghigo J.M., Beloin C.
    Environ. Microbiol. 12:1957-1977(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiSFMH_ECOLI
AccessioniPrimary (citable) accession number: P75715
Secondary accession number(s): P77078, Q2MBP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 26, 2007
Last modified: January 20, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.