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Protein

Uncharacterized fimbrial-like protein SfmH

Gene

sfmH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.1 Publication

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: EcoCyc

Keywordsi

LigandLectin, Mannose-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6293-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized fimbrial-like protein SfmH
Gene namesi
Name:sfmH
Ordered Locus Names:b0533, JW5071
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13884 sfmH

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell

Keywords - Cellular componenti

Fimbrium

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000921225 – 327Uncharacterized fimbrial-like protein SfmHAdd BLAST303

Proteomic databases

PaxDbiP75715
PRIDEiP75715

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261686, 4 interactors
STRINGi316385.ECDH10B_0489

Structurei

3D structure databases

ProteinModelPortaliP75715
SMRiP75715
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108M66 Bacteria
ENOG410ZUTT LUCA
HOGENOMiHOG000267835
InParanoidiP75715
KOiK07356
OMAiQMPFGVQ
PhylomeDBiP75715

Family and domain databases

Gene3Di2.60.40.1090, 1 hit
InterProiView protein in InterPro
IPR000259 Adhesion_dom_fimbrial
IPR036937 Adhesion_dom_fimbrial_sf
IPR008966 Adhesion_dom_sf
PfamiView protein in Pfam
PF00419 Fimbrial, 1 hit
SUPFAMiSSF49401 SSF49401, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P75715-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMACLCLAN ISWATVCANS TGVAEDEHYD LSNIFNSTNN QPGQIVVLPE
60 70 80 90 100
KSGWVGVSAI CPPGTLVNYT YRSYVTNFIV QETIDNYKYM QLHDYLLGAM
110 120 130 140 150
SLVDSVMDIQ FPPQNYIRMG TDPNVSQNLP FGVMDSRLIF RLKVIRPFIN
160 170 180 190 200
MVEIPRQVMF TVYVTSTPYD PLVTPVYTIS FGGRVEVPQN CELNAGQIVE
210 220 230 240 250
FDFGDIGASL FSAAGPGNRP AGVMPQTKSI AVKCTNVAAQ AYLTMRLEAS
260 270 280 290 300
AVSGQAMVSD NQDLGFIVAD QNDTPITPND LNSVIPFRLD AAAAANVTLR
310 320
AWPISITGQK PTEGPFSALG YLRVDYQ
Length:327
Mass (Da):35,696
Last modified:June 26, 2007 - v2
Checksum:i8FAF2EA0E77A4FC5
GO

Sequence cautioni

The sequence AAB40731 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAE76310 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA Translation: AAB40731.1 Different initiation.
U00096 Genomic DNA Translation: AAC73635.2
AP009048 Genomic DNA Translation: BAE76310.1 Different initiation.
PIRiD64785
RefSeqiNP_415066.2, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAC73635; AAC73635; b0533
BAE76310; BAE76310; BAE76310
GeneIDi945407
KEGGiecj:JW5071
eco:b0533
PATRICifig|511145.12.peg.554

Similar proteinsi

Entry informationi

Entry nameiSFMH_ECOLI
AccessioniPrimary (citable) accession number: P75715
Secondary accession number(s): P77078, Q2MBP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 26, 2007
Last modified: March 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health