Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

(S)-ureidoglycine aminohydrolase

Gene

allE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the anaerobic nitrogen utilization via the assimilation of allantoin. Catalyzes the second stereospecific hydrolysis reaction (deamination) of the allantoin degradation pathway, producing S-ureidoglycolate and ammonia from S-ureidoglycine.2 Publications

Catalytic activityi

(S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH3.1 Publication1 Publication

Cofactori

Mn2+1 PublicationNote: Also able to use Co2+).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi196ManganeseBy similarity1
Binding sitei196SubstrateBy similarity1
Metal bindingi198ManganeseBy similarity1
Metal bindingi202ManganeseBy similarity1
Metal bindingi236ManganeseBy similarity1
Binding sitei236SubstrateBy similarity1
Binding sitei249SubstrateBy similarity1
Binding sitei253SubstrateBy similarity1

GO - Molecular functioni

  • manganese ion binding Source: EcoCyc
  • ureidoglycine aminohydrolase activity Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPurine metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6284-MONOMER
MetaCyc:G6284-MONOMER
BRENDAi3.5.3.26 2026

Names & Taxonomyi

Protein namesi
Recommended name:
(S)-ureidoglycine aminohydrolase1 Publication (EC:3.5.3.261 Publication1 Publication)
Short name:
UGHY1 Publication
Short name:
UGlyAH
Gene namesi
Name:allE
Synonyms:glxB6, ylbA
Ordered Locus Names:b0515, JW0503
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13622 ylbA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001686441 – 261(S)-ureidoglycine aminohydrolaseAdd BLAST261

Proteomic databases

PaxDbiP75713
PRIDEiP75713

Expressioni

Inductioni

By glyoxylate and allantoin under anaerobic conditions.1 Publication

Interactioni

Subunit structurei

Monomer.2 Publications

Protein-protein interaction databases

BioGridi4262016, 8 interactors
DIPiDIP-12689N
IntActiP75713, 7 interactors
STRINGi316385.ECDH10B_0471

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 14Combined sources4
Beta strandi25 – 29Combined sources5
Helixi31 – 33Combined sources3
Beta strandi42 – 49Combined sources8
Helixi53 – 55Combined sources3
Beta strandi58 – 74Combined sources17
Beta strandi81 – 96Combined sources16
Beta strandi99 – 104Combined sources6
Beta strandi107 – 111Combined sources5
Beta strandi118 – 121Combined sources4
Beta strandi123 – 125Combined sources3
Beta strandi127 – 135Combined sources9
Beta strandi147 – 150Combined sources4
Helixi151 – 153Combined sources3
Beta strandi166 – 169Combined sources4
Beta strandi178 – 186Combined sources9
Beta strandi194 – 200Combined sources7
Beta strandi202 – 217Combined sources16
Beta strandi219 – 223Combined sources5
Beta strandi227 – 230Combined sources4
Beta strandi232 – 240Combined sources9
Beta strandi247 – 254Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RC6X-ray2.60A/B1-261[»]
ProteinModelPortaliP75713
SMRiP75713
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP75713

Family & Domainsi

Sequence similaritiesi

Belongs to the UGHY family.Curated

Phylogenomic databases

eggNOGiENOG4105S0E Bacteria
COG3257 LUCA
HOGENOMiHOG000219622
InParanoidiP75713
KOiK14977
OMAiLNRDWVE
PhylomeDBiP75713

Family and domain databases

Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR017627 CHP03214_cupin
IPR013096 Cupin_2
IPR008579 DUF861_Cupin_3
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PfamiView protein in Pfam
PF07883 Cupin_2, 1 hit
PF05899 Cupin_3, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR03214 ura-cupin, 1 hit

Sequencei

Sequence statusi: Complete.

P75713-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYLNNVTGY REDLLANRAI VKHGNFALLT PDGLVKNIIP GFENCDATIL
60 70 80 90 100
STPKLGASFV DYLVTLHQNG GNQQGFGGEG IETFLYVISG NITAKAEGKT
110 120 130 140 150
FALSEGGYLY CPPGSLMTFV NAQAEDSQIF LYKRRYVPVE GYAPWLVSGN
160 170 180 190 200
ASELERIHYE GMDDVILLDF LPKELGFDMN MHILSFAPGA SHGYIETHVQ
210 220 230 240 250
EHGAYILSGQ GVYNLDNNWI PVKKGDYIFM GAYSLQAGYG VGRGEAFSYI
260
YSKDCNRDVE I
Length:261
Mass (Da):28,730
Last modified:February 1, 1997 - v1
Checksum:iB424C7DBD34508D6
GO

Sequence cautioni

The sequence AAB93856 differs from that shown. Reason: Frameshift at position 222.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204A → T in AAB93856 (PubMed:10601204).Curated1
Sequence conflicti204A → T in AAB40267 (Ref. 2) Curated1
Sequence conflicti225 – 261GDYIF…RDVEI → RRLHLYGRLFFTGWLWCRAW in AAB40267 (Ref. 2) CuratedAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89279 Genomic DNA Translation: AAB93856.1 Frameshift.
U82664 Genomic DNA Translation: AAB40267.1
U00096 Genomic DNA Translation: AAC73617.1
AP009048 Genomic DNA Translation: BAE76293.1
PIRiB64783
RefSeqiNP_415048.1, NC_000913.3
WP_000540997.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73617; AAC73617; b0515
BAE76293; BAE76293; BAE76293
GeneIDi945149
KEGGiecj:JW0503
eco:b0515
PATRICifig|511145.12.peg.535

Similar proteinsi

Entry informationi

Entry nameiALLE_ECOLI
AccessioniPrimary (citable) accession number: P75713
Secondary accession number(s): O54410, P77128, Q2MBR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health