Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

(S)-ureidoglycine aminohydrolase

Gene

allE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the catabolism of purine nucleotides. Catalyzes the second, stereospecific hydrolysis reaction of the allantoin degradation pathway, producing S-ureidoglycolate and ammonia from S-ureidoglycine.2 Publications

Catalytic activityi

(S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH3.1 Publication

Cofactori

Mn2+1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi196 – 1961ManganeseBy similarity
Binding sitei196 – 1961SubstrateBy similarity
Metal bindingi198 – 1981ManganeseBy similarity
Metal bindingi202 – 2021ManganeseBy similarity
Metal bindingi236 – 2361ManganeseBy similarity
Binding sitei236 – 2361SubstrateBy similarity
Binding sitei249 – 2491SubstrateBy similarity
Binding sitei253 – 2531SubstrateBy similarity

GO - Molecular functioni

  • manganese ion binding Source: EcoCyc
  • ureidoglycine aminohydrolase activity Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6284-MONOMER.
ECOL316407:JW0503-MONOMER.
MetaCyc:G6284-MONOMER.
BRENDAi3.5.3.26. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
(S)-ureidoglycine aminohydrolase (EC:3.5.3.26)
Short name:
UGHY
Short name:
UGlyAH
Gene namesi
Name:allE
Synonyms:glxB6, ylbA
Ordered Locus Names:b0515, JW0503
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13622. ylbA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261(S)-ureidoglycine aminohydrolasePRO_0000168644Add
BLAST

Proteomic databases

PaxDbiP75713.

Expressioni

Inductioni

By glyoxylate and allantoin under anaerobic conditions.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262016. 7 interactions.
DIPiDIP-12689N.
IntActiP75713. 7 interactions.
STRINGi511145.b0515.

Structurei

Secondary structure

1
261
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 144Combined sources
Beta strandi25 – 295Combined sources
Helixi31 – 333Combined sources
Beta strandi42 – 498Combined sources
Helixi53 – 553Combined sources
Beta strandi58 – 7417Combined sources
Beta strandi81 – 9616Combined sources
Beta strandi99 – 1046Combined sources
Beta strandi107 – 1115Combined sources
Beta strandi118 – 1214Combined sources
Beta strandi123 – 1253Combined sources
Beta strandi127 – 1359Combined sources
Beta strandi147 – 1504Combined sources
Helixi151 – 1533Combined sources
Beta strandi166 – 1694Combined sources
Beta strandi178 – 1869Combined sources
Beta strandi194 – 2007Combined sources
Beta strandi202 – 21716Combined sources
Beta strandi219 – 2235Combined sources
Beta strandi227 – 2304Combined sources
Beta strandi232 – 2409Combined sources
Beta strandi247 – 2548Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RC6X-ray2.60A/B1-261[»]
ProteinModelPortaliP75713.
SMRiP75713. Positions 9-261.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP75713.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi98 – 1014Poly-Ser
Compositional biasi204 – 2074Poly-Leu

Sequence similaritiesi

Belongs to the UGHY family.Curated

Phylogenomic databases

eggNOGiENOG4105S0E. Bacteria.
COG3257. LUCA.
HOGENOMiHOG000219622.
InParanoidiP75713.
KOiK14977.
OMAiLNRDWVE.
PhylomeDBiP75713.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR017627. CHP03214_cupin.
IPR013096. Cupin_2.
IPR008579. DUF861_Cupin_3.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF07883. Cupin_2. 1 hit.
PF05899. Cupin_3. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03214. ura-cupin. 1 hit.

Sequencei

Sequence statusi: Complete.

P75713-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYLNNVTGY REDLLANRAI VKHGNFALLT PDGLVKNIIP GFENCDATIL
60 70 80 90 100
STPKLGASFV DYLVTLHQNG GNQQGFGGEG IETFLYVISG NITAKAEGKT
110 120 130 140 150
FALSEGGYLY CPPGSLMTFV NAQAEDSQIF LYKRRYVPVE GYAPWLVSGN
160 170 180 190 200
ASELERIHYE GMDDVILLDF LPKELGFDMN MHILSFAPGA SHGYIETHVQ
210 220 230 240 250
EHGAYILSGQ GVYNLDNNWI PVKKGDYIFM GAYSLQAGYG VGRGEAFSYI
260
YSKDCNRDVE I
Length:261
Mass (Da):28,730
Last modified:February 1, 1997 - v1
Checksum:iB424C7DBD34508D6
GO

Sequence cautioni

The sequence AAB93856 differs from that shown. Reason: Frameshift at position 222. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti204 – 2041A → T in AAB93856 (PubMed:10601204).Curated
Sequence conflicti204 – 2041A → T in AAB40267 (Ref. 2) Curated
Sequence conflicti225 – 26137GDYIF…RDVEI → RRLHLYGRLFFTGWLWCRAW in AAB40267 (Ref. 2) CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89279 Genomic DNA. Translation: AAB93856.1. Frameshift.
U82664 Genomic DNA. Translation: AAB40267.1.
U00096 Genomic DNA. Translation: AAC73617.1.
AP009048 Genomic DNA. Translation: BAE76293.1.
PIRiB64783.
RefSeqiNP_415048.1. NC_000913.3.
WP_000540997.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73617; AAC73617; b0515.
BAE76293; BAE76293; BAE76293.
GeneIDi945149.
KEGGiecj:JW0503.
eco:b0515.
PATRICi32116187. VBIEscCol129921_0535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89279 Genomic DNA. Translation: AAB93856.1. Frameshift.
U82664 Genomic DNA. Translation: AAB40267.1.
U00096 Genomic DNA. Translation: AAC73617.1.
AP009048 Genomic DNA. Translation: BAE76293.1.
PIRiB64783.
RefSeqiNP_415048.1. NC_000913.3.
WP_000540997.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RC6X-ray2.60A/B1-261[»]
ProteinModelPortaliP75713.
SMRiP75713. Positions 9-261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262016. 7 interactions.
DIPiDIP-12689N.
IntActiP75713. 7 interactions.
STRINGi511145.b0515.

Proteomic databases

PaxDbiP75713.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73617; AAC73617; b0515.
BAE76293; BAE76293; BAE76293.
GeneIDi945149.
KEGGiecj:JW0503.
eco:b0515.
PATRICi32116187. VBIEscCol129921_0535.

Organism-specific databases

EchoBASEiEB3387.
EcoGeneiEG13622. ylbA.

Phylogenomic databases

eggNOGiENOG4105S0E. Bacteria.
COG3257. LUCA.
HOGENOMiHOG000219622.
InParanoidiP75713.
KOiK14977.
OMAiLNRDWVE.
PhylomeDBiP75713.

Enzyme and pathway databases

BioCyciEcoCyc:G6284-MONOMER.
ECOL316407:JW0503-MONOMER.
MetaCyc:G6284-MONOMER.
BRENDAi3.5.3.26. 2026.

Miscellaneous databases

EvolutionaryTraceiP75713.
PROiP75713.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR017627. CHP03214_cupin.
IPR013096. Cupin_2.
IPR008579. DUF861_Cupin_3.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF07883. Cupin_2. 1 hit.
PF05899. Cupin_3. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03214. ura-cupin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALLE_ECOLI
AccessioniPrimary (citable) accession number: P75713
Secondary accession number(s): O54410, P77128, Q2MBR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.