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Protein

Inner membrane protein RclC

Gene

rclC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in reactive chlorine species (RCS) stress resistance.1 Publication

GO - Biological processi

  • response to hypochlorite Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciEcoCyc:G6171-MONOMER.
ECOL316407:JW5038-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane protein RclC
Alternative name(s):
Reactive chlorine resistance protein C
Gene namesi
Name:rclC
Synonyms:ykgB
Ordered Locus Names:b0301, JW5038
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13579. rclC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515PeriplasmicSequence analysisAdd
BLAST
Transmembranei16 – 3621HelicalSequence analysisAdd
BLAST
Topological domaini37 – 8549CytoplasmicSequence analysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST
Topological domaini107 – 1126PeriplasmicSequence analysis
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST
Topological domaini134 – 19764CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutants are more sensitive to HOCl treatment than wild-type cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Inner membrane protein RclCPRO_0000168566Add
BLAST

Proteomic databases

PaxDbiP75685.

Expressioni

Inductioni

Induced by RclR in response to hypochlorous acid (HOCl).1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259798. 5 interactions.
STRINGi511145.b0301.

Structurei

3D structure databases

ProteinModelPortaliP75685.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108KBJ. Bacteria.
COG3059. LUCA.
HOGENOMiHOG000282453.
InParanoidiP75685.
OMAiTTPEVYV.
PhylomeDBiP75685.

Family and domain databases

InterProiIPR007339. DUF417.
[Graphical view]
PfamiPF04224. DUF417. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75685-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKYLHLLSR GDKIGLTLIR LSIAIVFMWI GLLKFVPYEA DSITPFVANS
60 70 80 90 100
PLMSFFYEHP EDYKQYLTHE GEYKPEARAW QTANNTYGFS NGLGVVEVII
110 120 130 140 150
ALLVLANPVN RWLGLLGGLM AFTTPLVTLS FLITTPEAWV PALGDAHHGF
160 170 180 190
PYLSGAGRLV LKDTLMLAGA VMIMADSARE ILKQRSNESS STLKTEY
Length:197
Mass (Da):21,899
Last modified:April 27, 2001 - v2
Checksum:iFC45E94197045C5E
GO

Sequence cautioni

The sequence AAB18029 differs from that shown. Reason: Frameshift at position 138. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18029.1. Frameshift.
U00096 Genomic DNA. Translation: AAC73404.2.
AP009048 Genomic DNA. Translation: BAE76086.1.
PIRiE64756.
RefSeqiNP_414835.2. NC_000913.3.
WP_001299021.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73404; AAC73404; b0301.
BAE76086; BAE76086; BAE76086.
GeneIDi944974.
KEGGiecj:JW5038.
eco:b0301.
PATRICi32115733. VBIEscCol129921_0309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18029.1. Frameshift.
U00096 Genomic DNA. Translation: AAC73404.2.
AP009048 Genomic DNA. Translation: BAE76086.1.
PIRiE64756.
RefSeqiNP_414835.2. NC_000913.3.
WP_001299021.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP75685.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259798. 5 interactions.
STRINGi511145.b0301.

Proteomic databases

PaxDbiP75685.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73404; AAC73404; b0301.
BAE76086; BAE76086; BAE76086.
GeneIDi944974.
KEGGiecj:JW5038.
eco:b0301.
PATRICi32115733. VBIEscCol129921_0309.

Organism-specific databases

EchoBASEiEB3349.
EcoGeneiEG13579. rclC.

Phylogenomic databases

eggNOGiENOG4108KBJ. Bacteria.
COG3059. LUCA.
HOGENOMiHOG000282453.
InParanoidiP75685.
OMAiTTPEVYV.
PhylomeDBiP75685.

Enzyme and pathway databases

BioCyciEcoCyc:G6171-MONOMER.
ECOL316407:JW5038-MONOMER.

Miscellaneous databases

PROiP75685.

Family and domain databases

InterProiIPR007339. DUF417.
[Graphical view]
PfamiPF04224. DUF417. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRCLC_ECOLI
AccessioniPrimary (citable) accession number: P75685
Secondary accession number(s): P71303, Q2MCC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 27, 2001
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.