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Protein

Putative ferric transport system permease-like protein AfuB

Gene

afuB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

A severely truncated paralog of the AfuB uptake protein, homologous only to the last 20% of the intact protein in Actinobacillus.Curated

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G6137-MONOMER.
ECOL316407:JW0255-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ferric transport system permease-like protein AfuB
Gene namesi
Name:afuB
Synonyms:fbpB
Ordered Locus Names:b0263, JW0255
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14277. afuB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
Transmembranei39 – 59HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini60 – 81PeriplasmicSequence analysisAdd BLAST22
Transmembranei82 – 102HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini103 – 120CytoplasmicSequence analysis1 PublicationAdd BLAST18

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000600161 – 120Putative ferric transport system permease-like protein AfuBAdd BLAST120

Proteomic databases

EPDiP75681.
PRIDEiP75681.

Interactioni

Protein-protein interaction databases

BioGridi4263057. 4 interactors.
STRINGi316407.85674407.

Structurei

3D structure databases

ProteinModelPortaliP75681.
SMRiP75681.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 102ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST102

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1178. LUCA.
HOGENOMiHOG000201003.
KOiK02011.
PhylomeDBiP75681.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLPGQIDK SLDEASLSLR AGSLRTITHI LLPLLRPAIL SALIYSFVRA
60 70 80 90 100
ITTVSAIVFL VTPDTRVATA YILNRVEDGE YGVAIAYGSI LIVVMLAIIF
110 120
IFDWLIGESR TSRSKAKNQA
Length:120
Mass (Da):13,093
Last modified:November 30, 2016 - v3
Checksum:iDF63F7D8DB7F8655
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAA77931.2.
PIRiG64751.

Genome annotation databases

EnsemblBacteriaiBAA77931; BAA77931; BAA77931.
KEGGiecj:JW0255.
PATRICi48659724. VBIEscCol107702_0258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAA77931.2.
PIRiG64751.

3D structure databases

ProteinModelPortaliP75681.
SMRiP75681.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263057. 4 interactors.
STRINGi316407.85674407.

Proteomic databases

EPDiP75681.
PRIDEiP75681.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA77931; BAA77931; BAA77931.
KEGGiecj:JW0255.
PATRICi48659724. VBIEscCol107702_0258.

Organism-specific databases

EchoBASEiEB4025.
EcoGeneiEG14277. afuB.

Phylogenomic databases

eggNOGiCOG1178. LUCA.
HOGENOMiHOG000201003.
KOiK02011.
PhylomeDBiP75681.

Enzyme and pathway databases

BioCyciEcoCyc:G6137-MONOMER.
ECOL316407:JW0255-MONOMER.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAFUB_ECOLI
AccessioniPrimary (citable) accession number: P75681
Secondary accession number(s): Q9XB40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 30, 2016
Last modified: November 30, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene. The original protein is truncated by an IS1 element which is inserted right before residue 6. What was the original N-terminal of this protein is not known. Other genes of the operon were presumably also deleted by this IS1 event.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.