ID   Y159_MYCPN              Reviewed;         424 AA.
AC   P75586;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   27-MAR-2024, entry version 113.
DE   RecName: Full=UPF0053 protein MG146 homolog;
GN   OrderedLocusNames=MPN_159; ORFNames=MP672, VXpSPT7_orf424;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)
OS   (Mycoplasmoides pneumoniae).
OC   Bacteria; Mycoplasmatota; Mycoplasmoidales; Mycoplasmoidaceae;
OC   Mycoplasmoides.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129 / Subtype 1;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
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DR   EMBL; U00089; AAB96320.1; -; Genomic_DNA.
DR   PIR; S73998; S73998.
DR   RefSeq; NP_109847.1; NC_000912.1.
DR   RefSeq; WP_010874516.1; NZ_OU342337.1.
DR   AlphaFoldDB; P75586; -.
DR   SMR; P75586; -.
DR   STRING; 272634.MPN_159; -.
DR   EnsemblBacteria; AAB96320; AAB96320; MPN_159.
DR   GeneID; 66609193; -.
DR   KEGG; mpn:MPN_159; -.
DR   PATRIC; fig|272634.6.peg.177; -.
DR   HOGENOM; CLU_015237_4_1_14; -.
DR   OrthoDB; 9798188at2; -.
DR   BioCyc; MPNE272634:G1GJ3-266-MONOMER; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   PANTHER; PTHR22777; HEMOLYSIN-RELATED; 1.
DR   PANTHER; PTHR22777:SF33; UPF0053 PROTEIN YEGH; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF01595; CNNM; 1.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51846; CNNM; 1.
PE   3: Inferred from homology;
KW   CBS domain; Cell membrane; Membrane; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..424
FT                   /note="UPF0053 protein MG146 homolog"
FT                   /id="PRO_0000088379"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          6..191
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01193"
FT   DOMAIN          210..270
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          275..335
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ   SEQUENCE   424 AA;  48528 MW;  9B35BC1D1AC2CB65 CRC64;
     MESAPSGGLL ALIIISIILL ACISAVVSAY ETAITSITSY KWSNYVKTHN KQKKLTTKIV
     NHFQKNYSAC LITILVANNI VAILVSNILF LALDQSIKNP AISSALNLLI SGVLLLMLCE
     ITPKTLARIN IIRVLVYFAV VVYFFYILFW PITKLASIIF AKYEKAPPVS RRDVYFFIDE
     IEQNGLFTKE DGQLIKRTLI FDQVLVDQIM IKWNRVVYCY EGDPVKTIKE KFLHGQFSRM
     PVLDQTSNEV VGFIHLKDLF SSLEKSNEPF VLQELLYPAV LVSNTTPIKQ ALRQMRLHRA
     HLAVVQDKHH HTIGIVSMED IIEELVGEIY DEHDEVEAVQ TLDNNTWLVL PNVKAAFFFN
     KWIKRDLVKS KNMTIQRYLA SFENDGLNTQ NKLETPWFIA EAIVDSENPE QIRYEIRKKS
     DVVD
//