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Protein

UPF0053 protein MG146 homolog

Gene

MPN_159

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-166-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0053 protein MG146 homolog
Gene namesi
Ordered Locus Names:MPN_159
ORF Names:MP672, VXpSPT7_orf424
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence AnalysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence AnalysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence AnalysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424UPF0053 protein MG146 homologPRO_0000088379Add
BLAST

Proteomic databases

PaxDbiP75586.

Interactioni

Protein-protein interaction databases

STRINGi272634.MPN159.

Structurei

3D structure databases

ProteinModelPortaliP75586.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 190178DUF21Add
BLAST
Domaini210 – 27061CBS 1PROSITE-ProRule annotationAdd
BLAST
Domaini275 – 33561CBS 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0053 family.Curated
Contains 2 CBS domains.PROSITE-ProRule annotation
Contains 1 DUF21 domain.Curated

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1253.
OMAiFFNKWIK.
OrthoDBiEOG64FKB6.

Family and domain databases

InterProiIPR000644. CBS_dom.
IPR002550. DUF21.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF01595. DUF21. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESAPSGGLL ALIIISIILL ACISAVVSAY ETAITSITSY KWSNYVKTHN
60 70 80 90 100
KQKKLTTKIV NHFQKNYSAC LITILVANNI VAILVSNILF LALDQSIKNP
110 120 130 140 150
AISSALNLLI SGVLLLMLCE ITPKTLARIN IIRVLVYFAV VVYFFYILFW
160 170 180 190 200
PITKLASIIF AKYEKAPPVS RRDVYFFIDE IEQNGLFTKE DGQLIKRTLI
210 220 230 240 250
FDQVLVDQIM IKWNRVVYCY EGDPVKTIKE KFLHGQFSRM PVLDQTSNEV
260 270 280 290 300
VGFIHLKDLF SSLEKSNEPF VLQELLYPAV LVSNTTPIKQ ALRQMRLHRA
310 320 330 340 350
HLAVVQDKHH HTIGIVSMED IIEELVGEIY DEHDEVEAVQ TLDNNTWLVL
360 370 380 390 400
PNVKAAFFFN KWIKRDLVKS KNMTIQRYLA SFENDGLNTQ NKLETPWFIA
410 420
EAIVDSENPE QIRYEIRKKS DVVD
Length:424
Mass (Da):48,528
Last modified:February 1, 1997 - v1
Checksum:i9B35BC1D1AC2CB65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB96320.1.
PIRiS73998.
RefSeqiNP_109847.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96320; AAB96320; MPN_159.
GeneIDi877287.
KEGGimpn:MPN159.
PATRICi20021641. VBIMycPne110_0177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB96320.1.
PIRiS73998.
RefSeqiNP_109847.1. NC_000912.1.

3D structure databases

ProteinModelPortaliP75586.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272634.MPN159.

Proteomic databases

PaxDbiP75586.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB96320; AAB96320; MPN_159.
GeneIDi877287.
KEGGimpn:MPN159.
PATRICi20021641. VBIMycPne110_0177.

Phylogenomic databases

eggNOGiCOG1253.
OMAiFFNKWIK.
OrthoDBiEOG64FKB6.

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-166-MONOMER.

Family and domain databases

InterProiIPR000644. CBS_dom.
IPR002550. DUF21.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF01595. DUF21. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiY159_MYCPN
AccessioniPrimary (citable) accession number: P75586
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 4, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.