P75586 (Y159_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UPF0053 protein MG146 homolog

Gene names

Ordered Locus Names:	MPN_159
ORF Names:	MP672, VXpSPT7_orf424

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma pneumoniae

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the UPF0053 family. Contains 2 CBS domains. Contains 1 DUF21 domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	CBS domain Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 424	424	UPF0053 protein MG146 homolog		PRO_0000088379
Regions
	Transmembrane	7 – 27	21	Helical; Potential
	Transmembrane	71 – 91	21	Helical; Potential
	Transmembrane	101 – 121	21	Helical; Potential
	Transmembrane	135 – 155	21	Helical; Potential
	Domain	13 – 190	178	DUF21
	Domain	210 – 270	61	CBS 1
	Domain	275 – 335	61	CBS 2

Sequences

	Sequence		Length	Mass (Da)
	P75586 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 9B35BC1D1AC2CB65	FASTA	424	48,528
	10 20 30 40 50 60 MESAPSGGLL ALIIISIILL ACISAVVSAY ETAITSITSY KWSNYVKTHN KQKKLTTKIV 70 80 90 100 110 120 NHFQKNYSAC LITILVANNI VAILVSNILF LALDQSIKNP AISSALNLLI SGVLLLMLCE 130 140 150 160 170 180 ITPKTLARIN IIRVLVYFAV VVYFFYILFW PITKLASIIF AKYEKAPPVS RRDVYFFIDE 190 200 210 220 230 240 IEQNGLFTKE DGQLIKRTLI FDQVLVDQIM IKWNRVVYCY EGDPVKTIKE KFLHGQFSRM 250 260 270 280 290 300 PVLDQTSNEV VGFIHLKDLF SSLEKSNEPF VLQELLYPAV LVSNTTPIKQ ALRQMRLHRA 310 320 330 340 350 360 HLAVVQDKHH HTIGIVSMED IIEELVGEIY DEHDEVEAVQ TLDNNTWLVL PNVKAAFFFN 370 380 390 400 410 420 KWIKRDLVKS KNMTIQRYLA SFENDGLNTQ NKLETPWFIA EAIVDSENPE QIRYEIRKKS DVVD

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB96320.1.
PIR	S73998.
RefSeq	NP_109847.1. NC_000912.1.
3D structure databases
ProteinModelPortal	P75586.
ModBase	Search...
Protein-protein interaction databases
STRING	272634.MPN159.
Proteomic databases
PaxDb	P75586.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB96320; AAB96320; MPN_159.
GeneID	877287.
KEGG	mpn:MPN159.
PATRIC	20021641. VBIMycPne110_0177.
Phylogenomic databases
eggNOG	COG1253.
OMA	FFNKWIK.
ProtClustDB	CLSK336923.
Enzyme and pathway databases
BioCyc	MPNE272634:GJ6Z-166-MONOMER.
Family and domain databases
InterPro	IPR000644. Cysta_beta_synth_core. IPR002550. DUF21. [Graphical view]
Pfam	PF00571. CBS. 2 hits. PF01595. DUF21. 1 hit. [Graphical view]
SMART	SM00116. CBS. 2 hits. [Graphical view]
PROSITE	PS51371. CBS. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y159_MYCPN

Accession

Primary (citable) accession number: P75586

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program