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P75534

- GATA_MYCPN

UniProt

P75534 - GATA_MYCPN

Protein

Glutamyl-tRNA(Gln) amidotransferase subunit A

Gene

gatA

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) By similarity.By similarity

    Catalytic activityi

    ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei68 – 681Charge relay systemBy similarity
    Active sitei143 – 1431Charge relay systemBy similarity
    Active sitei167 – 1671Acyl-ester intermediateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-244-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamyl-tRNA(Gln) amidotransferase subunit A (EC:6.3.5.7)
    Short name:
    Glu-ADT subunit A
    Gene namesi
    Name:gatA
    Ordered Locus Names:MPN_237
    ORF Names:MP594
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 478478Glutamyl-tRNA(Gln) amidotransferase subunit APRO_0000105179Add
    BLAST

    Proteomic databases

    PaxDbiP75534.

    Interactioni

    Subunit structurei

    Heterotrimer of A, B and C subunits.By similarity

    Protein-protein interaction databases

    STRINGi272634.MPN237.

    Structurei

    3D structure databases

    ProteinModelPortaliP75534.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the amidase family. GatA subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0154.
    KOiK02433.
    OMAiYDILLAY.
    OrthoDBiEOG61P6R9.

    Family and domain databases

    Gene3Di3.90.1300.10. 1 hit.
    HAMAPiMF_00120. GatA.
    InterProiIPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    IPR004412. GatA.
    [Graphical view]
    PANTHERiPTHR11895. PTHR11895. 1 hit.
    PfamiPF01425. Amidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF75304. SSF75304. 1 hit.
    TIGRFAMsiTIGR00132. gatA. 1 hit.
    PROSITEiPS00571. AMIDASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P75534-1 [UniParc]FASTAAdd to Basket

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    MKSQILKLQQ TLTKKPASIN PLLQQIDGAI NEHWSSNFLL KNTVEWAQAQ    50
    APKNRSKSPL NNIPFVLKDN IATKGIVTTG GSRFLEDYIP PFSATVFELL 100
    NNSGALLVGK ANLDEFGLGG TGLHSGFGFV HHPWNETLIP GGSSSGSAYA 150
    VARGIVPFSI GTDTGDSVRR PASICNIVGF KPTYGLISRN GVYPYAPSLD 200
    HVGIFARYVY DVALVSDEII KHDKADFSAQ KSPDAGKFTR SLKESFNKQI 250
    KIGYLKPLEE WFDIELSKKW NSLKERITLE GCELIPFHFP LELLEVIDPV 300
    YKLISYSEAV SCYSNLTGIV FGQKLFEPNQ ASDFSKTITA NRDRFFGEQL 350
    KRRFIIGAFG TDKNNFTKYF EKAQKIRRVM VDAYLNLFKE ADFIVSPSAS 400
    GFTKTIAAVQ KGESFTNLVD DFLQLANFAG NPSITIPWLV KQKDQTIGLS 450
    VNANCFHDKQ LLQVAAWLEE LFQIEHDD 478
    Length:478
    Mass (Da):53,230
    Last modified:February 1, 1997 - v1
    Checksum:iF228E9AE4F641071
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96242.1.
    PIRiS73920.
    RefSeqiNP_109925.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB96242; AAB96242; MPN_237.
    GeneIDi877201.
    KEGGimpn:MPN237.
    PATRICi20021799. VBIMycPne110_0256.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96242.1 .
    PIRi S73920.
    RefSeqi NP_109925.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75534.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272634.MPN237.

    Proteomic databases

    PaxDbi P75534.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB96242 ; AAB96242 ; MPN_237 .
    GeneIDi 877201.
    KEGGi mpn:MPN237.
    PATRICi 20021799. VBIMycPne110_0256.

    Phylogenomic databases

    eggNOGi COG0154.
    KOi K02433.
    OMAi YDILLAY.
    OrthoDBi EOG61P6R9.

    Enzyme and pathway databases

    BioCyci MPNE272634:GJ6Z-244-MONOMER.

    Family and domain databases

    Gene3Di 3.90.1300.10. 1 hit.
    HAMAPi MF_00120. GatA.
    InterProi IPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    IPR004412. GatA.
    [Graphical view ]
    PANTHERi PTHR11895. PTHR11895. 1 hit.
    Pfami PF01425. Amidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF75304. SSF75304. 1 hit.
    TIGRFAMsi TIGR00132. gatA. 1 hit.
    PROSITEi PS00571. AMIDASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiGATA_MYCPN
    AccessioniPrimary (citable) accession number: P75534
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3