P75531 (TRXB_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thioredoxin reductase
Short name=TRXR
EC=1.8.1.9

Gene names

Name:	trxB
Ordered Locus Names:	MPN_240
ORF Names:	MP591

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129)

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Miscellaneous	The active site is a redox-active disulfide bond.
Sequence similarities	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Redox-active center
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	removal of superoxide radicals Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro thioredoxin-disulfide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Thioredoxin reductase		PRO_0000166738
Regions
	Nucleotide binding	45 – 52	8	FAD By similarity
	Nucleotide binding	288 – 297	10	FAD By similarity
Amino acid modifications
	Disulfide bond	145 ↔ 148		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	P75531 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 7155E4AF8D2A2EE7	FASTA	315	34,532
	10 20 30 40 50 60 MLKVKSDFLT KDQVIYDVAI VGAGPAGIAA GIYGKRANLN LAIIEGSTPG GKVVKTNIVE 70 80 90 100 110 120 NYPGYKSITG PDLGLEMYNH LIDLEPTFFY ANLIKLDKAA DTFILYLDDK TVVFAKTVIY 130 140 150 160 170 180 ATGMLERKLG VAKEDHFYGK GISYCAICDG SLYKDQVVGV VGGGNSAIQE ALYLASMAKT 190 200 210 220 230 240 VHLIHRREGF RADETALNKL RNLPNVVFHL NYTVKELLGN NTLNGIVLQN TLDHSTKQID 250 260 270 280 290 300 LNCVFPYIGF ESITKPVEHL NLKLDPQGFL ITNEQMETSL KGLFAAGDCR SKHFRQIGTA 310 INDGIIAVLT IRDVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The thioredoxin reductase system of mycoplasmas." Ben-Menachem G., Himmelreich R., Herrmann R., Aharonowitz Y., Rottem S. Microbiology 143:1933-1940(1997) [PubMed: 9202470] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 29342 / M129.
[2]	"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U51988 Genomic DNA. Translation: AAC45451.1. U00089 Genomic DNA. Translation: AAB96239.1.
PIR	S73917.
RefSeq	NP_109928.1. NC_000912.1.
3D structure databases
ProteinModelPortal	P75531.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	877259.
GenomeReviews	Gene locus MPN_240 in contig U00089_GR.
KEGG	mpn:MPN240.
PATRIC	20021805. VBIMycPne110_0259.
Phylogenomic databases
HOGENOM	HBG669726.
OMA	HYIANSI.
PhylomeDB	P75531.
ProtClustDB	CLSK542145.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-543. MPNE272634:MPN240-MONOMER.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR008255. Pyr_nucl-diS_OxRdtase_2_AS. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR000103. Pyridine_nuc-diS_OxRdtase_2. IPR005982. Thioredox_Rdtase. [Graphical view]
KO	K00384.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
TIGRFAMs	TIGR01292. TRX_reduct. 1 hit.
PROSITE	PS00573. PYRIDINE_REDOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRXB_MYCPN

Accession

Primary (citable) accession number: P75531

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program