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Protein

Diadenylate cyclase

Gene

dacB

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.UniRule annotation

Catalytic activityi

2 ATP = 2 diphosphate + cyclic di-3',5'-adenylate.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPNE272634:G1GJ3-387-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Diadenylate cyclaseUniRule annotation (EC:2.7.7.85UniRule annotation)
Short name:
DACUniRule annotation
Alternative name(s):
Cyclic-di-AMP synthaseUniRule annotation
Short name:
c-di-AMP synthaseUniRule annotation
Diadenylyl cyclase1 Publication
Gene namesi
Name:dacB1 PublicationUniRule annotation
Ordered Locus Names:MPN_244
ORF Names:K04_orf202, MP588
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000808 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002104181 – 202Diadenylate cyclaseAdd BLAST202

Interactioni

Subunit structurei

Probably oligomerizes.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP75528
SMRiP75528
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 185DACUniRule annotationAdd BLAST157

Sequence similaritiesi

Belongs to the adenylate cyclase family. DacB/CdaS subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK18672
OMAiTFYKITK

Family and domain databases

Gene3Di3.40.1700.10, 1 hit
HAMAPiMF_00838 DacB, 1 hit
InterProiView protein in InterPro
IPR014046 c-di-AMP_synthase
IPR034701 CdaA
IPR034693 CdaS
IPR036888 DNA_integrity_DisA_N_sf
IPR003390 DNA_integrity_scan_DisA_N
PfamiView protein in Pfam
PF02457 DisA_N, 1 hit
PIRSFiPIRSF004793 UCP004793, 1 hit
SUPFAMiSSF143597 SSF143597, 1 hit
TIGRFAMsiTIGR00159 TIGR00159, 1 hit
PROSITEiView protein in PROSITE
PS51794 DAC, 1 hit

Sequencei

Sequence statusi: Complete.

P75528-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTVEVFSVI ILVLLFLILA LTLLFVLLNK RTRSFVIRTF TGLFRSKHTT
60 70 80 90 100
SQKNFYDNLT STLLRLSTDK IGAIIAIENQ DSLESYVNIG YRVTSDFSPE
110 120 130 140 150
LLVTIFYNKQ SPLHDGAVIV RDYQIVSVSS YFPMTRQLID VSYGSRHRSA
160 170 180 190 200
LGLTEKCDAI VFIVSETTGK ISVAVRGVIK TLSSNSDRLQ DQIIHYLTVK

PG
Length:202
Mass (Da):22,733
Last modified:February 1, 1997 - v1
Checksum:iF2E3F12431ADCE18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA Translation: AAB96236.1
PIRiS73914
RefSeqiNP_109932.1, NC_000912.1
WP_010874601.1, NC_000912.1

Genome annotation databases

EnsemblBacteriaiAAB96236; AAB96236; MPN_244
GeneIDi876807
KEGGimpn:MPN244
PATRICifig|272634.6.peg.263

Similar proteinsi

Entry informationi

Entry nameiDACB_MYCPN
AccessioniPrimary (citable) accession number: P75528
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 25, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health