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Protein

Diadenylate cyclase

Gene

dacB

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.UniRule annotation

Catalytic activityi

2 ATP = 2 diphosphate + cyclic di-3',5'-adenylate.UniRule annotation

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-251-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Diadenylate cyclaseUniRule annotation (EC:2.7.7.85UniRule annotation)
Short name:
DACUniRule annotation
Alternative name(s):
Cyclic-di-AMP synthaseUniRule annotation
Short name:
c-di-AMP synthaseUniRule annotation
Gene namesi
Name:dacBUniRule annotation
Ordered Locus Names:MPN_244
ORF Names:K04_orf202, MP588
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000808 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Diadenylate cyclasePRO_0000210418Add
BLAST

Interactioni

Subunit structurei

Probably oligomerizes.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP75528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 185157DACUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylate cyclase family. DacB/CdaS subfamily.UniRule annotation
Contains 1 DAC domain.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OMAiNTNAGRV.
OrthoDBiEOG6DRPM4.

Family and domain databases

HAMAPiMF_00838. DacB.
InterProiIPR014046. c-di-AMP_synthase-like.
IPR003390. DNA_integrity_scan_DisA_N.
[Graphical view]
PfamiPF02457. DisA_N. 1 hit.
[Graphical view]
PIRSFiPIRSF004793. UCP004793. 1 hit.
TIGRFAMsiTIGR00159. TIGR00159. 1 hit.
PROSITEiPS51794. DAC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75528-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTVEVFSVI ILVLLFLILA LTLLFVLLNK RTRSFVIRTF TGLFRSKHTT
60 70 80 90 100
SQKNFYDNLT STLLRLSTDK IGAIIAIENQ DSLESYVNIG YRVTSDFSPE
110 120 130 140 150
LLVTIFYNKQ SPLHDGAVIV RDYQIVSVSS YFPMTRQLID VSYGSRHRSA
160 170 180 190 200
LGLTEKCDAI VFIVSETTGK ISVAVRGVIK TLSSNSDRLQ DQIIHYLTVK

PG
Length:202
Mass (Da):22,733
Last modified:February 1, 1997 - v1
Checksum:iF2E3F12431ADCE18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB96236.1.
PIRiS73914.
RefSeqiNP_109932.1. NC_000912.1.
WP_010874601.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96236; AAB96236; MPN_244.
GeneIDi876807.
KEGGimpn:MPN244.
PATRICi20021813. VBIMycPne110_0263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB96236.1.
PIRiS73914.
RefSeqiNP_109932.1. NC_000912.1.
WP_010874601.1. NC_000912.1.

3D structure databases

ProteinModelPortaliP75528.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB96236; AAB96236; MPN_244.
GeneIDi876807.
KEGGimpn:MPN244.
PATRICi20021813. VBIMycPne110_0263.

Phylogenomic databases

OMAiNTNAGRV.
OrthoDBiEOG6DRPM4.

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-251-MONOMER.

Family and domain databases

HAMAPiMF_00838. DacB.
InterProiIPR014046. c-di-AMP_synthase-like.
IPR003390. DNA_integrity_scan_DisA_N.
[Graphical view]
PfamiPF02457. DisA_N. 1 hit.
[Graphical view]
PIRSFiPIRSF004793. UCP004793. 1 hit.
TIGRFAMsiTIGR00159. TIGR00159. 1 hit.
PROSITEiPS51794. DAC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiDACB_MYCPN
AccessioniPrimary (citable) accession number: P75528
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.