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P75527

- DEF_MYCPN

UniProt

P75527 - DEF_MYCPN

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Protein

Peptide deformylase

Gene

def

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).By similarity

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.

Cofactori

Binds 1 Fe2+ ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi134 – 1341IronBy similarity
Metal bindingi178 – 1781IronBy similarity
Active sitei179 – 1791By similarity
Metal bindingi182 – 1821IronBy similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-252-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:MPN_245
ORF Names:MP587
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Peptide deformylasePRO_0000082803Add
BLAST

Proteomic databases

PaxDbiP75527.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself1EBI-2259869,EBI-2259869

Protein-protein interaction databases

IntActiP75527. 1 interaction.
STRINGi272634.MPN245.

Structurei

3D structure databases

ProteinModelPortaliP75527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.Curated

Phylogenomic databases

eggNOGiCOG0242.
KOiK01462.
OMAiTISIFRI.
OrthoDBiEOG6PZXGQ.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

P75527-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKILPVSTI SIFRIILILP QINMELLPTK AWLVLDDVKE INEPTKPVQF
60 70 80 90 100
PLDQASLDCI AKMMAYVDAS YNGDAEKYGI IPGIGIAANQ IGYWKQMFYI
110 120 130 140 150
HLMDGGVEHK CLLINPKIIN LSANKSFLKS GEGCLSVPKM HQGYVIRHEW
160 170 180 190 200
ITITGFDWLQ QKEITITATG LFGMCLQHEF DHLQGRFYYH RINPLNPLFT
210
NKEWKVINPA LPSDSE
Length:216
Mass (Da):24,592
Last modified:February 1, 1997 - v1
Checksum:i361F434048B505DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB96235.1.
PIRiS73913.
RefSeqiNP_109933.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96235; AAB96235; MPN_245.
GeneIDi876781.
KEGGimpn:MPN245.
PATRICi20021815. VBIMycPne110_0264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB96235.1 .
PIRi S73913.
RefSeqi NP_109933.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75527.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P75527. 1 interaction.
STRINGi 272634.MPN245.

Proteomic databases

PaxDbi P75527.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB96235 ; AAB96235 ; MPN_245 .
GeneIDi 876781.
KEGGi mpn:MPN245.
PATRICi 20021815. VBIMycPne110_0264.

Phylogenomic databases

eggNOGi COG0242.
KOi K01462.
OMAi TISIFRI.
OrthoDBi EOG6PZXGQ.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-252-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiDEF_MYCPN
AccessioniPrimary (citable) accession number: P75527
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 1, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3