P75526 (KGUA_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	MPN_246
ORF Names:	MP586

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma pneumoniae

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 239	239	Guanylate kinase HAMAP-Rule MF_00328		PRO_0000170568
Regions
	Domain	55 – 235	181	Guanylate kinase-like
	Nucleotide binding	62 – 69	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P75526 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 59247177879BE2F6	FASTA	239	27,002
	10 20 30 40 50 60 MQSRLAWSKG NWTGLVGSLI SLTSSSTSHA LVGNNSILIC GKIKIILNIE MVDTGRIFVI 70 80 90 100 110 120 TGPSGVGKSS LVRCLIDHFK DKLRYSISAT TRKMRNSETE GVDYFFKDKA EFEKLIAADA 130 140 150 160 170 180 FVEWAMYNDN YYGTLKSQAE QIIHNGGNLV LEIEYQGALQ VKQKYPNDVV LIFIKPPSME 190 200 210 220 230 ELLVRLKKRN DEDAITIQNR LKQAEKECQQ IGHFKYVVTN NEFDKTLAEL QAILLAEFN

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB96234.1.
PIR	S73912.
RefSeq	NP_109934.1. NC_000912.1.
3D structure databases
ProteinModelPortal	P75526.
ModBase	Search...
Protein-protein interaction databases
IntAct	P75526. 2 interactions.
STRING	272634.MPN246.
Proteomic databases
PaxDb	P75526.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB96234; AAB96234; MPN_246.
GeneID	876860.
KEGG	mpn:MPN246.
PATRIC	20021817. VBIMycPne110_0265.
Phylogenomic databases
eggNOG	COG0194.
KO	K00942.
OMA	EWAEFAG.
ProtClustDB	CLSK542148.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-575. MPNE272634:GJ6Z-253-MONOMER.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase.
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_MYCPN

Accession

Primary (citable) accession number: P75526

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program