P75520 (PGSA_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
EC=2.7.8.5

Alternative name(s):
Phosphatidylglycerophosphate synthase
Short name=PGP synthase

Gene names

Name:	pgsA
Ordered Locus Names:	MPN_253
ORF Names:	MP579

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129)

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity.
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase		PRO_0000056778
Regions
	Transmembrane	30 – 50	21	Helical; Potential
	Transmembrane	58 – 78	21	Helical; Potential
	Transmembrane	112 – 132	21	Helical; Potential
	Transmembrane	159 – 179	21	Helical; Potential
	Transmembrane	192 – 212	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P75520 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 76192D444013B6D4	FASTA	227	26,050
	10 20 30 40 50 60 MRSPFPVPMV PLTIKTWQKK LPNWLTIYRI FIAVPTIIFL GLNHLLGSVA SFTVLGNVTI 70 80 90 100 110 120 HLQVSLFIGG VLFITAVISD YLDGYWARKW RVVSNFGKLW DPLADKVIIN GVLIALVAYG 130 140 150 160 170 180 YFHFSFLIVI VLRDLVLDGL RFYAQEKQLI IPANQWGKWK TTWQMIAILM SCFVFSFSLK 190 200 210 220 ETNSANTKIF YWAIVHLPYY LATAFSLVSF GIYAQQIYKT IKVKVKL

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB96227.1.
PIR	S73905.
RefSeq	NP_109941.1. NC_000912.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P75520. 1 interaction.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	876733.
GenomeReviews	Gene locus MPN_253 in contig U00089_GR.
KEGG	mpn:MPN253.
PATRIC	20021831. VBIMycPne110_0272.
Phylogenomic databases
HOGENOM	HBG686655.
OMA	FGKLWDP.
PhylomeDB	P75520.
ProtClustDB	CLSK542151.
Enzyme and pathway databases
BioCyc	MPNE272634:MPN253-MONOMER.
Family and domain databases
InterPro	IPR000462. CDP-OH_P_trans. IPR004570. Phosphatidylglycerol_P_synth. [Graphical view]
KO	K00995.
Pfam	PF01066. CDP-OH_P_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMs	TIGR00560. PgsA. 1 hit.
PROSITE	PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGSA_MYCPN

Accession

Primary (citable) accession number: P75520

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program