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P75508 (NADK_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:MPN_267
ORF Names:MP566
OrganismMycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]
Taxonomic identifier272634 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259NAD kinase HAMAP-Rule MF_00361
PRO_0000120638

Regions

Nucleotide binding43 – 442NAD By similarity
Nucleotide binding111 – 1122NAD By similarity

Sites

Active site431Proton acceptor By similarity
Binding site1361NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
P75508 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: AD381E3FB1F13805

FASTA25929,034
        10         20         30         40         50         60 
MKYKIFASTT PQTEPVLQKL KQVLKGCEAV EKGFDYLFVL GGDGFFVSTV ANYNCHNCRV 

        70         80         90        100        110        120 
VGINTGHLGF YTSFNEKDLD DNFLQKLQQC HFQRISLLEV SVNGQQHLVL NELAVYTNTA 

       130        140        150        160        170        180 
YPINIFIDGE AWEFYRGSGL LIGPRTGSTA LAKSAKGAVI FPGIDVLQII EMNPLLHPNQ 

       190        200        210        220        230        240 
VTIQSPIILP KETQVEFVVK KAFNPQQFPT FYCDGRKLEL PNADTTLALK LVQSTPMFNI 

       250 
SLKTQDFINK LKSTFIKQS 

« Hide

References

[1]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00089 Genomic DNA. Translation: AAB96214.1.
PIRS73892.
RefSeqNP_109955.1. NC_000912.1.

3D structure databases

ProteinModelPortalP75508.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP75508. 1 interaction.
STRING272634.MPN267.

Proteomic databases

PaxDbP75508.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB96214; AAB96214; MPN_267.
GeneID877097.
KEGGmpn:MPN267.
PATRIC20021859. VBIMycPne110_0286.

Phylogenomic databases

eggNOGCOG0061.
KOK00858.
OMAFCPVYSV.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycMPNE272634:GJ6Z-274-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_MYCPN
AccessionPrimary (citable) accession number: P75508
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names