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P75508

- NADK_MYCPN

UniProt

P75508 - NADK_MYCPN

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Protein
NAD kinase
Gene
nadK, MPN_267, MP566
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei43 – 431Proton acceptor By similarity
Binding sitei136 – 1361NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 442NAD By similarity
Nucleotide bindingi111 – 1122NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-274-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:MPN_267
ORF Names:MP566
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259NAD kinaseUniRule annotation
PRO_0000120638Add
BLAST

Proteomic databases

PaxDbiP75508.

Interactioni

Protein-protein interaction databases

IntActiP75508. 1 interaction.
STRINGi272634.MPN267.

Structurei

3D structure databases

ProteinModelPortaliP75508.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiFCPVYSV.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

P75508-1 [UniParc]FASTAAdd to Basket

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MKYKIFASTT PQTEPVLQKL KQVLKGCEAV EKGFDYLFVL GGDGFFVSTV    50
ANYNCHNCRV VGINTGHLGF YTSFNEKDLD DNFLQKLQQC HFQRISLLEV 100
SVNGQQHLVL NELAVYTNTA YPINIFIDGE AWEFYRGSGL LIGPRTGSTA 150
LAKSAKGAVI FPGIDVLQII EMNPLLHPNQ VTIQSPIILP KETQVEFVVK 200
KAFNPQQFPT FYCDGRKLEL PNADTTLALK LVQSTPMFNI SLKTQDFINK 250
LKSTFIKQS 259
Length:259
Mass (Da):29,034
Last modified:February 1, 1997 - v1
Checksum:iAD381E3FB1F13805
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB96214.1.
PIRiS73892.
RefSeqiNP_109955.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96214; AAB96214; MPN_267.
GeneIDi877097.
KEGGimpn:MPN267.
PATRICi20021859. VBIMycPne110_0286.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB96214.1 .
PIRi S73892.
RefSeqi NP_109955.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75508.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P75508. 1 interaction.
STRINGi 272634.MPN267.

Proteomic databases

PaxDbi P75508.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB96214 ; AAB96214 ; MPN_267 .
GeneIDi 877097.
KEGGi mpn:MPN267.
PATRICi 20021859. VBIMycPne110_0286.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi FCPVYSV.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-274-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiNADK_MYCPN
AccessioniPrimary (citable) accession number: P75508
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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