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P75500

- SYK_MYCPN

UniProt

P75500 - SYK_MYCPN

Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

    Cofactori

    Binds 3 magnesium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi399 – 3991Magnesium 1By similarity
    Metal bindingi406 – 4061Magnesium 1By similarity
    Metal bindingi406 – 4061Magnesium 2By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-284-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysine--tRNA ligase (EC:6.1.1.6)
    Alternative name(s):
    Lysyl-tRNA synthetase
    Short name:
    LysRS
    Gene namesi
    Name:lysS
    Ordered Locus Names:MPN_277
    ORF Names:MP558
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 489489Lysine--tRNA ligasePRO_0000152651Add
    BLAST

    Proteomic databases

    PaxDbiP75500.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiP75500. 2 interactions.
    STRINGi272634.MPN277.

    Structurei

    3D structure databases

    ProteinModelPortaliP75500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1190.
    KOiK04567.
    OMAiFKAPYAR.
    OrthoDBiEOG69PQ2M.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_00252. Lys_tRNA_synth_class2.
    InterProiIPR004364. aa-tRNA-synt_II.
    IPR018150. aa-tRNA-synt_II-like.
    IPR006195. aa-tRNA-synth_II.
    IPR002313. Lys-tRNA-ligase_II.
    IPR018149. Lys-tRNA-synth_II_C.
    IPR012340. NA-bd_OB-fold.
    IPR004365. NA-bd_OB_tRNA.
    [Graphical view]
    PANTHERiPTHR22594. PTHR22594. 1 hit.
    PfamiPF00152. tRNA-synt_2. 1 hit.
    PF01336. tRNA_anti-codon. 1 hit.
    [Graphical view]
    PRINTSiPR00982. TRNASYNTHLYS.
    SUPFAMiSSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00499. lysS_bact. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P75500-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDRLNDQAQ NRLQKLLNLK QTGNDPYLIT KIENTHSAAS FQKAFANQSD    50
    AELKQYQVIL TGRIIALRQT FIIIQDFSGK MQLYINKKTA PELFEYFNNY 100
    IDLGDQIVAT GHPMMTKTGV LTLNVERLQI VAKCLQTPPE KWHGLTDPEA 150
    RARKRYLDLT YNRAQVEVFL KRTQIITAIR TFLNEAGFLE VETPILQAVL 200
    GGANAKPFKT HYNALKGDFY LRIANEIALK KLIVGGLPKV YEMGRMFRNE 250
    GVDTTHNPEF TSIEMYQANA DYAVMMDLTE NLIKFVCKTL NQWSFNWNGQ 300
    TLDLAKPFKK VKMVDLICQV TGVNFDDVKD DQTAIALAKQ HKVELKKHEQ 350
    NKQHIINRFF EQFCEHTLIQ PTFVTHYPKA VSPLAKQDPH NPEFTERFEL 400
    FINTKELANA YSELNDPLEQ RARFEQQLQE KRMGNDEASE LDESFLDALS 450
    FGLPPTGGLG IGVDRLVMLL CECSSIRDVV FFPQLRELK 489
    Length:489
    Mass (Da):56,081
    Last modified:February 1, 1997 - v1
    Checksum:iE3D643B73DEDBCA0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96206.1.
    PIRiS73884.
    RefSeqiNP_109965.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB96206; AAB96206; MPN_277.
    GeneIDi876870.
    KEGGimpn:MPN277.
    PATRICi20021881. VBIMycPne110_0297.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96206.1 .
    PIRi S73884.
    RefSeqi NP_109965.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P75500. 2 interactions.
    STRINGi 272634.MPN277.

    Proteomic databases

    PaxDbi P75500.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB96206 ; AAB96206 ; MPN_277 .
    GeneIDi 876870.
    KEGGi mpn:MPN277.
    PATRICi 20021881. VBIMycPne110_0297.

    Phylogenomic databases

    eggNOGi COG1190.
    KOi K04567.
    OMAi FKAPYAR.
    OrthoDBi EOG69PQ2M.

    Enzyme and pathway databases

    BioCyci MPNE272634:GJ6Z-284-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_00252. Lys_tRNA_synth_class2.
    InterProi IPR004364. aa-tRNA-synt_II.
    IPR018150. aa-tRNA-synt_II-like.
    IPR006195. aa-tRNA-synth_II.
    IPR002313. Lys-tRNA-ligase_II.
    IPR018149. Lys-tRNA-synth_II_C.
    IPR012340. NA-bd_OB-fold.
    IPR004365. NA-bd_OB_tRNA.
    [Graphical view ]
    PANTHERi PTHR22594. PTHR22594. 1 hit.
    Pfami PF00152. tRNA-synt_2. 1 hit.
    PF01336. tRNA_anti-codon. 1 hit.
    [Graphical view ]
    PRINTSi PR00982. TRNASYNTHLYS.
    SUPFAMi SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00499. lysS_bact. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiSYK_MYCPN
    AccessioniPrimary (citable) accession number: P75500
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3