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P75500

- SYK_MYCPN

UniProt

P75500 - SYK_MYCPN

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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

Cofactori

Mg2+By similarityNote: Binds 3 Mg(2+) ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi399 – 3991Magnesium 1By similarity
Metal bindingi406 – 4061Magnesium 1By similarity
Metal bindingi406 – 4061Magnesium 2By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. nucleic acid binding Source: InterPro

GO - Biological processi

  1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-284-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase (EC:6.1.1.6)
Alternative name(s):
Lysyl-tRNA synthetase
Short name:
LysRS
Gene namesi
Name:lysS
Ordered Locus Names:MPN_277
ORF Names:MP558
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Lysine--tRNA ligasePRO_0000152651Add
BLAST

Proteomic databases

PaxDbiP75500.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiP75500. 2 interactions.
STRINGi272634.MPN277.

Structurei

3D structure databases

ProteinModelPortaliP75500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1190.
KOiK04567.
OMAiFKAPYAR.
OrthoDBiEOG69PQ2M.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00252. Lys_tRNA_synth_class2.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR00982. TRNASYNTHLYS.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00499. lysS_bact. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75500-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDRLNDQAQ NRLQKLLNLK QTGNDPYLIT KIENTHSAAS FQKAFANQSD
60 70 80 90 100
AELKQYQVIL TGRIIALRQT FIIIQDFSGK MQLYINKKTA PELFEYFNNY
110 120 130 140 150
IDLGDQIVAT GHPMMTKTGV LTLNVERLQI VAKCLQTPPE KWHGLTDPEA
160 170 180 190 200
RARKRYLDLT YNRAQVEVFL KRTQIITAIR TFLNEAGFLE VETPILQAVL
210 220 230 240 250
GGANAKPFKT HYNALKGDFY LRIANEIALK KLIVGGLPKV YEMGRMFRNE
260 270 280 290 300
GVDTTHNPEF TSIEMYQANA DYAVMMDLTE NLIKFVCKTL NQWSFNWNGQ
310 320 330 340 350
TLDLAKPFKK VKMVDLICQV TGVNFDDVKD DQTAIALAKQ HKVELKKHEQ
360 370 380 390 400
NKQHIINRFF EQFCEHTLIQ PTFVTHYPKA VSPLAKQDPH NPEFTERFEL
410 420 430 440 450
FINTKELANA YSELNDPLEQ RARFEQQLQE KRMGNDEASE LDESFLDALS
460 470 480
FGLPPTGGLG IGVDRLVMLL CECSSIRDVV FFPQLRELK
Length:489
Mass (Da):56,081
Last modified:February 1, 1997 - v1
Checksum:iE3D643B73DEDBCA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB96206.1.
PIRiS73884.
RefSeqiNP_109965.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96206; AAB96206; MPN_277.
GeneIDi876870.
KEGGimpn:MPN277.
PATRICi20021881. VBIMycPne110_0297.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB96206.1 .
PIRi S73884.
RefSeqi NP_109965.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P75500. 2 interactions.
STRINGi 272634.MPN277.

Proteomic databases

PaxDbi P75500.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB96206 ; AAB96206 ; MPN_277 .
GeneIDi 876870.
KEGGi mpn:MPN277.
PATRICi 20021881. VBIMycPne110_0297.

Phylogenomic databases

eggNOGi COG1190.
KOi K04567.
OMAi FKAPYAR.
OrthoDBi EOG69PQ2M.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-284-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_00252. Lys_tRNA_synth_class2.
InterProi IPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view ]
PANTHERi PTHR22594. PTHR22594. 1 hit.
Pfami PF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view ]
PRINTSi PR00982. TRNASYNTHLYS.
SUPFAMi SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00499. lysS_bact. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiSYK_MYCPN
AccessioniPrimary (citable) accession number: P75500
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3