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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi399Magnesium 1By similarity1
Metal bindingi406Magnesium 1By similarity1
Metal bindingi406Magnesium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPNE272634:G1GJ3-435-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase (EC:6.1.1.6)
Alternative name(s):
Lysyl-tRNA synthetase
Short name:
LysRS
Gene namesi
Name:lysS
Ordered Locus Names:MPN_277
ORF Names:MP558
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000808 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001526511 – 489Lysine--tRNA ligaseAdd BLAST489

Proteomic databases

PRIDEiP75500

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiP75500, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliP75500
SMRiP75500
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK04567
OMAiMMNIIPG

Family and domain databases

CDDicd00775 LysRS_core, 1 hit
HAMAPiMF_00252 Lys_tRNA_synth_class2, 1 hit
InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR002313 Lys-tRNA-ligase_II
IPR018149 Lys-tRNA-synth_II_C
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PfamiView protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PRINTSiPR00982 TRNASYNTHLYS
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00499 lysS_bact, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

P75500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRLNDQAQ NRLQKLLNLK QTGNDPYLIT KIENTHSAAS FQKAFANQSD
60 70 80 90 100
AELKQYQVIL TGRIIALRQT FIIIQDFSGK MQLYINKKTA PELFEYFNNY
110 120 130 140 150
IDLGDQIVAT GHPMMTKTGV LTLNVERLQI VAKCLQTPPE KWHGLTDPEA
160 170 180 190 200
RARKRYLDLT YNRAQVEVFL KRTQIITAIR TFLNEAGFLE VETPILQAVL
210 220 230 240 250
GGANAKPFKT HYNALKGDFY LRIANEIALK KLIVGGLPKV YEMGRMFRNE
260 270 280 290 300
GVDTTHNPEF TSIEMYQANA DYAVMMDLTE NLIKFVCKTL NQWSFNWNGQ
310 320 330 340 350
TLDLAKPFKK VKMVDLICQV TGVNFDDVKD DQTAIALAKQ HKVELKKHEQ
360 370 380 390 400
NKQHIINRFF EQFCEHTLIQ PTFVTHYPKA VSPLAKQDPH NPEFTERFEL
410 420 430 440 450
FINTKELANA YSELNDPLEQ RARFEQQLQE KRMGNDEASE LDESFLDALS
460 470 480
FGLPPTGGLG IGVDRLVMLL CECSSIRDVV FFPQLRELK
Length:489
Mass (Da):56,081
Last modified:February 1, 1997 - v1
Checksum:iE3D643B73DEDBCA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA Translation: AAB96206.1
PIRiS73884
RefSeqiNP_109965.1, NC_000912.1
WP_010874634.1, NC_000912.1

Genome annotation databases

EnsemblBacteriaiAAB96206; AAB96206; MPN_277
GeneIDi876870
KEGGimpn:MPN277
PATRICifig|272634.6.peg.297

Similar proteinsi

Entry informationi

Entry nameiSYK_MYCPN
AccessioniPrimary (citable) accession number: P75500
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health