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Protein

UDP-galactopyranose mutase

Gene

glf

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the conversion of UDP-GalP into UDP-GalF through a 2-keto intermediate.By similarity

Catalytic activityi

UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei25 – 251FADBy similarity
Binding sitei52 – 521FAD; via amide nitrogenBy similarity
Binding sitei171 – 1711UDP-GalPBy similarity
Binding sitei175 – 1751UDP-GalPBy similarity
Binding sitei200 – 2001UDP-GalPBy similarity
Binding sitei297 – 2971UDP-GalPBy similarity
Binding sitei306 – 3061UDP-GalPBy similarity
Binding sitei345 – 3451UDP-GalPBy similarity
Binding sitei374 – 3741FADBy similarity
Binding sitei380 – 3801UDP-GalPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 452FADBy similarity
Nucleotide bindingi71 – 722FADBy similarity
Nucleotide bindingi381 – 3866FADBy similarity

GO - Molecular functioni

  1. UDP-galactopyranose mutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-285-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-galactopyranose mutase (EC:5.4.99.9)
Short name:
UGM
Alternative name(s):
UDP-GALP mutase
Uridine 5-diphosphate galactopyranose mutase
Gene namesi
Name:glf
Ordered Locus Names:MPN_278
ORF Names:MP557
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399UDP-galactopyranose mutasePRO_0000087510Add
BLAST

Proteomic databases

PaxDbiP75499.
PRIDEiP75499.

Interactioni

Protein-protein interaction databases

IntActiP75499. 2 interactions.
STRINGi272634.MPN278.

Structurei

3D structure databases

ProteinModelPortaliP75499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0562.
KOiK01854.
OMAiEYPEAYE.
OrthoDBiEOG62K1X2.

Family and domain databases

Gene3Di3.40.50.720. 3 hits.
InterProiIPR016040. NAD(P)-bd_dom.
IPR004379. UDP-GALP_mutase.
IPR015899. UDP-GalPyranose_mutase_C.
[Graphical view]
PANTHERiPTHR21197. PTHR21197. 1 hit.
PfamiPF03275. GLF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00031. UDP-GALP_mutase. 1 hit.

Sequencei

Sequence statusi: Complete.

P75499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLFSFPNYV NWNKFDFIVL GAGISGIVLS HVLAQHGKSV LLLEKRNQLG
60 70 80 90 100
GNCYDKLDET TGLLFHQYGP HIFHTDNQKV MDFIQPFFEL NNYQHRVGLQ
110 120 130 140 150
LDNNLDLTLP FDFSQMRKLL DTKTASSLIN FFQQHFPAEK HLTLMQLQTI
160 170 180 190 200
NFAPVQQLYQ FLKIKVYGPY SVKMWGMPLE QIDPSVLGRV KISLSENSSY
210 220 230 240 250
FPTATIQGLP KGGYTKAFTK MVDHPLIDLR LNCPANLISV NNNQLLFANQ
260 270 280 290 300
PITKPVVYCG LIDQLFGYCF GRLQYRSLHF EWKRYAVKQH QAYPVMNWPL
310 320 330 340 350
HPTITRQVEY KQLTQEGLES NQTIVSCETP GAFREGDPRF MEPYYPLNDV
360 370 380 390
SNNALFARYL KLANAIPNIH LLGRLALYQY IDMDRAIAQS LAKAEQLLQ
Length:399
Mass (Da):45,910
Last modified:February 1, 1997 - v1
Checksum:i53ED30655351639A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB96205.1.
PIRiS73883.
RefSeqiNP_109966.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96205; AAB96205; MPN_278.
GeneIDi876844.
KEGGimpn:MPN278.
PATRICi20021883. VBIMycPne110_0298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB96205.1.
PIRiS73883.
RefSeqiNP_109966.1. NC_000912.1.

3D structure databases

ProteinModelPortaliP75499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP75499. 2 interactions.
STRINGi272634.MPN278.

Proteomic databases

PaxDbiP75499.
PRIDEiP75499.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB96205; AAB96205; MPN_278.
GeneIDi876844.
KEGGimpn:MPN278.
PATRICi20021883. VBIMycPne110_0298.

Phylogenomic databases

eggNOGiCOG0562.
KOiK01854.
OMAiEYPEAYE.
OrthoDBiEOG62K1X2.

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-285-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 3 hits.
InterProiIPR016040. NAD(P)-bd_dom.
IPR004379. UDP-GALP_mutase.
IPR015899. UDP-GalPyranose_mutase_C.
[Graphical view]
PANTHERiPTHR21197. PTHR21197. 1 hit.
PfamiPF03275. GLF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00031. UDP-GALP_mutase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiGLF_MYCPN
AccessioniPrimary (citable) accession number: P75499
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 29, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.