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P75499

- GLF_MYCPN

UniProt

P75499 - GLF_MYCPN

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Protein
UDP-galactopyranose mutase
Gene
glf, MPN_278, MP557
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Involved in the conversion of UDP-GalP into UDP-GalF through a 2-keto intermediate By similarity.

Catalytic activityi

UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose.

Cofactori

FAD By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei25 – 251FAD By similarity
Binding sitei52 – 521FAD; via amide nitrogen By similarity
Binding sitei171 – 1711UDP-GalP By similarity
Binding sitei175 – 1751UDP-GalP By similarity
Binding sitei200 – 2001UDP-GalP By similarity
Binding sitei297 – 2971UDP-GalP By similarity
Binding sitei306 – 3061UDP-GalP By similarity
Binding sitei345 – 3451UDP-GalP By similarity
Binding sitei374 – 3741FAD By similarity
Binding sitei380 – 3801UDP-GalP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 452FAD By similarity
Nucleotide bindingi71 – 722FAD By similarity
Nucleotide bindingi381 – 3866FAD By similarity

GO - Molecular functioni

  1. UDP-galactopyranose mutase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-285-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-galactopyranose mutase (EC:5.4.99.9)
    Short name:
    UGM
    Alternative name(s):
    UDP-GALP mutase
    Uridine 5-diphosphate galactopyranose mutase
    Gene namesi
    Name:glf
    Ordered Locus Names:MPN_278
    ORF Names:MP557
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 399399UDP-galactopyranose mutase
    PRO_0000087510Add
    BLAST

    Proteomic databases

    PaxDbiP75499.
    PRIDEiP75499.

    Interactioni

    Protein-protein interaction databases

    IntActiP75499. 2 interactions.
    STRINGi272634.MPN278.

    Structurei

    3D structure databases

    ProteinModelPortaliP75499.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0562.
    KOiK01854.
    OMAiGKQWQTD.
    OrthoDBiEOG62K1X2.

    Family and domain databases

    Gene3Di3.40.50.720. 3 hits.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR004379. UDP-GALP_mutase.
    IPR015899. UDP-GalPyranose_mutase_C.
    [Graphical view]
    PANTHERiPTHR21197. PTHR21197. 1 hit.
    PfamiPF03275. GLF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00031. UDP-GALP_mutase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P75499-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLFSFPNYV NWNKFDFIVL GAGISGIVLS HVLAQHGKSV LLLEKRNQLG    50
    GNCYDKLDET TGLLFHQYGP HIFHTDNQKV MDFIQPFFEL NNYQHRVGLQ 100
    LDNNLDLTLP FDFSQMRKLL DTKTASSLIN FFQQHFPAEK HLTLMQLQTI 150
    NFAPVQQLYQ FLKIKVYGPY SVKMWGMPLE QIDPSVLGRV KISLSENSSY 200
    FPTATIQGLP KGGYTKAFTK MVDHPLIDLR LNCPANLISV NNNQLLFANQ 250
    PITKPVVYCG LIDQLFGYCF GRLQYRSLHF EWKRYAVKQH QAYPVMNWPL 300
    HPTITRQVEY KQLTQEGLES NQTIVSCETP GAFREGDPRF MEPYYPLNDV 350
    SNNALFARYL KLANAIPNIH LLGRLALYQY IDMDRAIAQS LAKAEQLLQ 399
    Length:399
    Mass (Da):45,910
    Last modified:February 1, 1997 - v1
    Checksum:i53ED30655351639A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96205.1.
    PIRiS73883.
    RefSeqiNP_109966.1. NC_000912.1.
    WP_010874635.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB96205; AAB96205; MPN_278.
    GeneIDi876844.
    KEGGimpn:MPN278.
    PATRICi20021883. VBIMycPne110_0298.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96205.1 .
    PIRi S73883.
    RefSeqi NP_109966.1. NC_000912.1.
    WP_010874635.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75499.
    ModBasei Search...

    Protein-protein interaction databases

    IntActi P75499. 2 interactions.
    STRINGi 272634.MPN278.

    Proteomic databases

    PaxDbi P75499.
    PRIDEi P75499.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB96205 ; AAB96205 ; MPN_278 .
    GeneIDi 876844.
    KEGGi mpn:MPN278.
    PATRICi 20021883. VBIMycPne110_0298.

    Phylogenomic databases

    eggNOGi COG0562.
    KOi K01854.
    OMAi GKQWQTD.
    OrthoDBi EOG62K1X2.

    Enzyme and pathway databases

    BioCyci MPNE272634:GJ6Z-285-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 3 hits.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR004379. UDP-GALP_mutase.
    IPR015899. UDP-GalPyranose_mutase_C.
    [Graphical view ]
    PANTHERi PTHR21197. PTHR21197. 1 hit.
    Pfami PF03275. GLF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00031. UDP-GALP_mutase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiGLF_MYCPN
    AccessioniPrimary (citable) accession number: P75499
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: September 3, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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