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P75484

- LSPA_MYCPN

UniProt

P75484 - LSPA_MYCPN

Protein

Lipoprotein signal peptidase

Gene

lspA

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    This protein specifically catalyzes the removal of signal peptides from prolipoproteins.By similarity

    Catalytic activityi

    Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei131 – 1311By similarity
    Active sitei157 – 1571By similarity

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aspartyl protease, Hydrolase, Protease

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-300-MONOMER.
    UniPathwayiUPA00665.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipoprotein signal peptidase (EC:3.4.23.36)
    Alternative name(s):
    Prolipoprotein signal peptidase
    Signal peptidase II
    Short name:
    SPase II
    Gene namesi
    Name:lspA
    Synonyms:lsp
    Ordered Locus Names:MPN_293
    ORF Names:MP542
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 184184Lipoprotein signal peptidasePRO_0000178795Add
    BLAST

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MPN_387P753951EBI-2258812,EBI-2258802

    Protein-protein interaction databases

    IntActiP75484. 1 interaction.
    STRINGi272634.MPN293.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei156 – 17621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase A8 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0597.
    KOiK03101.
    OrthoDBiEOG647V1T.

    Family and domain databases

    HAMAPiMF_00161. LspA.
    InterProiIPR001872. Peptidase_A8.
    [Graphical view]
    PfamiPF01252. Peptidase_A8. 1 hit.
    [Graphical view]
    PRINTSiPR00781. LIPOSIGPTASE.
    TIGRFAMsiTIGR00077. lspA. 1 hit.
    PROSITEiPS00855. SPASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P75484-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKAPTFFSK LLKQILFANR KPFLYYKLAL ILFVGFVILF QVFMLRAALN    50
    GEKGINGANG TDVARSSFIS IYVIGNKGVG FSLLADQPGL VYFLQGFLSF 100
    IALFFLVFST SYNYIFWITT LAFGSLGNFF DRLTSGSGEV LDYFVFSGGN 150
    SVFNLADCCI TFSFIGLFLS FLIQFFKEMK QTKS 184
    Length:184
    Mass (Da):20,586
    Last modified:February 1, 1997 - v1
    Checksum:iC29480B17C7B98A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96190.1.
    PIRiS73868.
    RefSeqiNP_109981.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB96190; AAB96190; MPN_293.
    GeneIDi877085.
    KEGGimpn:MPN293.
    PATRICi20021921. VBIMycPne110_0317.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96190.1 .
    PIRi S73868.
    RefSeqi NP_109981.1. NC_000912.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P75484. 1 interaction.
    STRINGi 272634.MPN293.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB96190 ; AAB96190 ; MPN_293 .
    GeneIDi 877085.
    KEGGi mpn:MPN293.
    PATRICi 20021921. VBIMycPne110_0317.

    Phylogenomic databases

    eggNOGi COG0597.
    KOi K03101.
    OrthoDBi EOG647V1T.

    Enzyme and pathway databases

    UniPathwayi UPA00665 .
    BioCyci MPNE272634:GJ6Z-300-MONOMER.

    Family and domain databases

    HAMAPi MF_00161. LspA.
    InterProi IPR001872. Peptidase_A8.
    [Graphical view ]
    Pfami PF01252. Peptidase_A8. 1 hit.
    [Graphical view ]
    PRINTSi PR00781. LIPOSIGPTASE.
    TIGRFAMsi TIGR00077. lspA. 1 hit.
    PROSITEi PS00855. SPASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiLSPA_MYCPN
    AccessioniPrimary (citable) accession number: P75484
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. Peptidase families
      Classification of peptidase families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3