Reviewed, UniProtKB/Swiss-Prot P75479 (PLSC_MYCPN)

Names and origin

Protein names

Recommended name:
    Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
      Short name=1-AGP acyltransferase
      Short name=1-AGPAT
    EC=2.3.1.51
Alternative name(s):
    Lysophosphatidic acid acyltransferase
      Short name=LPAAT

Gene names

Name:	plsC
Ordered Locus Names:	MPN_299
ORF Names:	MP537

Organism

Mycoplasma pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

2104 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position.
Catalytic activity	Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
Domain	The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.
Sequence similarities	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	membrane Inferred from electronic annotation. Source: InterPro
Molecular function	1-acylglycerol-3-phosphate O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase		PRO_0000208173
Regions
	Motif	92 – 97	6	HXXXXD motif

Sequences

	Sequence		Length	Mass (Da)
	P75479-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 79D933AD8203927F	FASTA	266	30,414
	10 20 30 40 50 60 MKKLTQAFLR FCLRFLQLLS LVLVLPVFVL MLISSLISAK NYESIPENYP PEIRFKKVYR 70 80 90 100 110 120 LVSLFLYIKG VKVVIVNPEN VPKKAVLVVA NHKSNLDPLI LIKAFGKTEG VPPLTFIAKI 130 140 150 160 170 180 ELQDTWLFKI MKLIDCVFID RKNLRQMAAS LEQQQQIIRQ GTALCVFPEG TRVLSRQIGE 190 200 210 220 230 240 FKSGALKVAY NAFVPIVPLT IVGSMGHMES KKRLQKAQVE RDRGYKIQVI FNTPINPINF 250 260 NQIDSQNVAN NVWREISQTY AQYCQD

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00089 Genomic DNA. Translation: AAB96185.1.
PIR	S73863.
RefSeq	NP_109987.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	877232.
GenomeReviews	Gene locus MPN_299 in contig U00089_GR.
KEGG	mpn:MPN299.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P75479.
OMA	GEFKSGA.
Enzyme and pathway databases
BioCyc	MPNE272634:MPN299-MON.
BRENDA	2.3.1.51. 39500.
Family and domain databases
InterPro	IPR002123. Acyltransferase. IPR004552. AGP_acyltrans. [Graphical view]
Pfam	PF01553. Acyltransferase. 1 hit. [Graphical view]
SMART	SM00563. PlsC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00530. AGP_acyltrn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PLSC_MYCPN

Accession

Primary (citable) accession number: P75479

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	November 3, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)