P75479 (PLSC_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
Short name=1-AGP acyltransferase
Short name=1-AGPAT
EC=2.3.1.51

Alternative name(s):
Lysophosphatidic acid acyltransferase
Short name=LPAAT

Gene names

Name:	plsC
Ordered Locus Names:	MPN_299
ORF Names:	MP537

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129)

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position.
Catalytic activity	Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
Domain	The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.
Sequence similarities	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	membrane Inferred from electronic annotation. Source: InterPro
Molecular function	1-acylglycerol-3-phosphate O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase		PRO_0000208173
Regions
	Motif	92 – 97	6	HXXXXD motif

Sequences

	Sequence		Length	Mass (Da)
	P75479 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 79D933AD8203927F	FASTA	266	30,414
	10 20 30 40 50 60 MKKLTQAFLR FCLRFLQLLS LVLVLPVFVL MLISSLISAK NYESIPENYP PEIRFKKVYR 70 80 90 100 110 120 LVSLFLYIKG VKVVIVNPEN VPKKAVLVVA NHKSNLDPLI LIKAFGKTEG VPPLTFIAKI 130 140 150 160 170 180 ELQDTWLFKI MKLIDCVFID RKNLRQMAAS LEQQQQIIRQ GTALCVFPEG TRVLSRQIGE 190 200 210 220 230 240 FKSGALKVAY NAFVPIVPLT IVGSMGHMES KKRLQKAQVE RDRGYKIQVI FNTPINPINF 250 260 NQIDSQNVAN NVWREISQTY AQYCQD

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB96185.1.
PIR	S73863.
RefSeq	NP_109987.1. NC_000912.1.
3D structure databases
ProteinModelPortal	P75479.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	877232.
GenomeReviews	Gene locus MPN_299 in contig U00089_GR.
KEGG	mpn:MPN299.
PATRIC	20021933. VBIMycPne110_0323.
Phylogenomic databases
HOGENOM	HBG571672.
OMA	GEFKSGA.
PhylomeDB	P75479.
ProtClustDB	CLSK335198.
Enzyme and pathway databases
BioCyc	MPNE272634:MPN299-MONOMER.
Family and domain databases
InterPro	IPR002123. Acyltransferase. IPR004552. AGP_acyltrans. [Graphical view]
KO	K00655.
Pfam	PF01553. Acyltransferase. 1 hit. [Graphical view]
SMART	SM00563. PlsC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00530. AGP_acyltrn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PLSC_MYCPN

Accession

Primary (citable) accession number: P75479

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program