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P75473 (OTCC_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ornithine carbamoyltransferase, catabolic
Short name=OTCase
EC=2.1.3.3
Gene names
Name:arcB
Ordered Locus Names:MPN_306
ORF Names:MP530
OrganismMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifier272634 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109

Pathway

Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109

Subcellular location

Cytoplasm Probable HAMAP MF_01109.

Sequence similarities

Belongs to the ATCase/OTCase family.

Sequence caution

The sequence AAB96178.1 differs from that shown. Reason: Frameshift at position 32.

Ontologies

Keywords
   Biological processArginine metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentornithine carbamoyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Ornithine carbamoyltransferase, catabolic HAMAP MF_01109
PRO_0000112954

Regions

Region58 – 625Carbamoyl phosphate binding By similarity
Region279 – 2824Ornithine binding By similarity

Sites

Binding site1091Carbamoyl phosphate By similarity
Binding site1361Carbamoyl phosphate By similarity
Site1491Important for structural integrity By similarity

Sequences

Sequence LengthMass (Da)Tools
P75473 [UniParc].

Last modified July 11, 2003. Version 2.
Checksum: 51BC8925AF8888EF

FASTA34638,149
        10         20         30         40         50         60 
MPINLKGRSL DSALNFTTAQ INYLIDLAID LNAVNTKLHI QNRPLAGKNI VLLFQKDSTR 

        70         80         90        100        110        120 
TRCAFEVAAF DLGMGCTYIG PSGSNFGKKE SIEDTAKVLG SMYDGIEFRG FKQSDVDALV 

       130        140        150        160        170        180 
KYSGVPVWNG LTDAEHPTQM LADYMTIKEL KGDLKGRKIV FAGDIKNNVA RSLMIGAAFV 

       190        200        210        220        230        240 
GMDIVLVGPK AQHELVQNGA GYKEVFEQCQ ALFQLNGGSV SFSTDKLQAA KNADVIYTDV 

       250        260        270        280        290        300 
WLSLGEDFSL FEERIQELGQ FQVDMAMIKA AKSDVIFLHC LPAFHDDHTS FSLEIKQKLG 

       310        320        330        340 
KKYPVVKTGA MEVTDTVFQS KHNMAFIQAE NRLHTIKAVI LATLGY

« Hide

References

[1]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U00089 Genomic DNA. Translation: AAB96178.1. Frameshift.
PIRS73856.
RefSeqNP_109994.1. NC_000912.1.

3D structure databases

ProteinModelPortalP75473.
ModBaseSearch...

Protein-protein interaction databases

IntActP75473. 2 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID876935.
GenomeReviewsGene locus MPN_306 in contig U00089_GR.
KEGGmpn:MPN306.
PATRIC20021964. VBIMycPne110_0330.

Phylogenomic databases

HOGENOMHBG579429.
OMAVRICTPE.
PhylomeDBP75473.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-533.
MPNE272634:MPN306-MONOMER.

Family and domain databases

HAMAPMF_01109. OTCase.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
KOK00611.
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMSSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMsTIGR00658. Orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTCC_MYCPN
AccessionPrimary (citable) accession number: P75473
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 11, 2003
Last modified: January 25, 2012
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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