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P75461

- RIR2_MYCPN

UniProt

P75461 - RIR2_MYCPN

Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdF

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi87 – 871Iron 1By similarity
    Metal bindingi121 – 1211Iron 1By similarity
    Active sitei125 – 1251By similarity
    Metal bindingi215 – 2151Iron 2

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. deoxyribonucleotide biosynthetic process Source: InterPro
    3. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-339-MONOMER.
    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:nrdF
    Ordered Locus Names:MPN_322
    ORF Names:MP514
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. ribonucleoside-diphosphate reductase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Ribonucleoside-diphosphate reductase subunit betaPRO_0000190484Add
    BLAST

    Proteomic databases

    PaxDbiP75461.

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.By similarity

    Protein-protein interaction databases

    IntActiP75461. 4 interactions.
    STRINGi272634.MPN322.

    Structurei

    3D structure databases

    ProteinModelPortaliP75461.
    SMRiP75461. Positions 24-307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0208.
    KOiK00526.
    OMAiQSPIDYA.
    OrthoDBiEOG68DD19.

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR026494. RNR_NrdF.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    TIGRFAMsiTIGR04171. RNR_1b_NrdF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P75461-1 [UniParc]FASTAAdd to Basket

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    MANTKKYFLE SVSPLEYAQK KFQGNLRSVN WNLVDDEKDL EVWNRITQNF    50
    WLPEKIPVSN DIPSWKQLSK EWQDLITKTF TGLTLLDTIQ ATIGDIKQID 100
    YALTDHEQVI YANFAFMVGV HARSYGTIFS TLCTSEQITE AHEWVVKTES 150
    LQKRAKALIP YYTGKDPLKS KVAAALMPGF LLYGGFYLPF YLSSRKQLPN 200
    TSDIIRLILR DKVIHNYYSG YKFQRKVEKM SKEKQAEMKR FVFDLMYELI 250
    ELEKAYLKEL YEGFGIVEDA IKFSIYNAGK FLQNLGYDSP FTEEETRIKP 300
    EIFAQLSARA DENHDFFSGN GSSYVMGISE ETEDKDWDF 339
    Length:339
    Mass (Da):39,413
    Last modified:February 1, 1997 - v1
    Checksum:iAE2FA78C2B745176
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96162.1.
    PIRiS73840.
    RefSeqiNP_110010.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB96162; AAB96162; MPN_322.
    GeneIDi876942.
    KEGGimpn:MPN322.
    PATRICi20021998. VBIMycPne110_0346.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96162.1 .
    PIRi S73840.
    RefSeqi NP_110010.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75461.
    SMRi P75461. Positions 24-307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P75461. 4 interactions.
    STRINGi 272634.MPN322.

    Proteomic databases

    PaxDbi P75461.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB96162 ; AAB96162 ; MPN_322 .
    GeneIDi 876942.
    KEGGi mpn:MPN322.
    PATRICi 20021998. VBIMycPne110_0346.

    Phylogenomic databases

    eggNOGi COG0208.
    KOi K00526.
    OMAi QSPIDYA.
    OrthoDBi EOG68DD19.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .
    BioCyci MPNE272634:GJ6Z-339-MONOMER.

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR026494. RNR_NrdF.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    TIGRFAMsi TIGR04171. RNR_1b_NrdF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiRIR2_MYCPN
    AccessioniPrimary (citable) accession number: P75461
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Seems to lack two of the iron-binding residues.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3