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P75461

- RIR2_MYCPN

UniProt

P75461 - RIR2_MYCPN

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Protein
Ribonucleoside-diphosphate reductase subunit beta
Gene
nrdF, MPN_322, MP514
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi87 – 871Iron 1 By similarity
Metal bindingi121 – 1211Iron 1 By similarity
Active sitei125 – 1251 By similarity
Metal bindingi215 – 2151Iron 2

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
  2. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  3. deoxyribonucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-339-MONOMER.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdF
Ordered Locus Names:MPN_322
ORF Names:MP514
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribonucleoside-diphosphate reductase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Ribonucleoside-diphosphate reductase subunit beta
PRO_0000190484Add
BLAST

Proteomic databases

PaxDbiP75461.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

IntActiP75461. 4 interactions.
STRINGi272634.MPN322.

Structurei

3D structure databases

ProteinModelPortaliP75461.
SMRiP75461. Positions 24-307.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
KOiK00526.
OMAiQSPIDYA.
OrthoDBiEOG68DD19.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026494. RNR_NrdF.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR04171. RNR_1b_NrdF. 1 hit.

Sequencei

Sequence statusi: Complete.

P75461-1 [UniParc]FASTAAdd to Basket

« Hide

MANTKKYFLE SVSPLEYAQK KFQGNLRSVN WNLVDDEKDL EVWNRITQNF    50
WLPEKIPVSN DIPSWKQLSK EWQDLITKTF TGLTLLDTIQ ATIGDIKQID 100
YALTDHEQVI YANFAFMVGV HARSYGTIFS TLCTSEQITE AHEWVVKTES 150
LQKRAKALIP YYTGKDPLKS KVAAALMPGF LLYGGFYLPF YLSSRKQLPN 200
TSDIIRLILR DKVIHNYYSG YKFQRKVEKM SKEKQAEMKR FVFDLMYELI 250
ELEKAYLKEL YEGFGIVEDA IKFSIYNAGK FLQNLGYDSP FTEEETRIKP 300
EIFAQLSARA DENHDFFSGN GSSYVMGISE ETEDKDWDF 339
Length:339
Mass (Da):39,413
Last modified:February 1, 1997 - v1
Checksum:iAE2FA78C2B745176
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB96162.1.
PIRiS73840.
RefSeqiNP_110010.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96162; AAB96162; MPN_322.
GeneIDi876942.
KEGGimpn:MPN322.
PATRICi20021998. VBIMycPne110_0346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB96162.1 .
PIRi S73840.
RefSeqi NP_110010.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75461.
SMRi P75461. Positions 24-307.
ModBasei Search...

Protein-protein interaction databases

IntActi P75461. 4 interactions.
STRINGi 272634.MPN322.

Proteomic databases

PaxDbi P75461.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB96162 ; AAB96162 ; MPN_322 .
GeneIDi 876942.
KEGGi mpn:MPN322.
PATRICi 20021998. VBIMycPne110_0346.

Phylogenomic databases

eggNOGi COG0208.
KOi K00526.
OMAi QSPIDYA.
OrthoDBi EOG68DD19.

Enzyme and pathway databases

UniPathwayi UPA00326 .
BioCyci MPNE272634:GJ6Z-339-MONOMER.

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026494. RNR_NrdF.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
TIGRFAMsi TIGR04171. RNR_1b_NrdF. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiRIR2_MYCPN
AccessioniPrimary (citable) accession number: P75461
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Seems to lack two of the iron-binding residues.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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