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P75461 (RIR2_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase subunit beta

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:nrdF
Ordered Locus Names:MPN_322
ORF Names:MP514
OrganismMycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]
Taxonomic identifier272634 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Tetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Caution

Seems to lack two of the iron-binding residues.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Ribonucleoside-diphosphate reductase subunit beta
PRO_0000190484

Sites

Active site1251 By similarity
Metal binding871Iron 1 By similarity
Metal binding1211Iron 1 By similarity
Metal binding2151Iron 2

Sequences

Sequence LengthMass (Da)Tools
P75461 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: AE2FA78C2B745176

FASTA33939,413
        10         20         30         40         50         60 
MANTKKYFLE SVSPLEYAQK KFQGNLRSVN WNLVDDEKDL EVWNRITQNF WLPEKIPVSN 

        70         80         90        100        110        120 
DIPSWKQLSK EWQDLITKTF TGLTLLDTIQ ATIGDIKQID YALTDHEQVI YANFAFMVGV 

       130        140        150        160        170        180 
HARSYGTIFS TLCTSEQITE AHEWVVKTES LQKRAKALIP YYTGKDPLKS KVAAALMPGF 

       190        200        210        220        230        240 
LLYGGFYLPF YLSSRKQLPN TSDIIRLILR DKVIHNYYSG YKFQRKVEKM SKEKQAEMKR 

       250        260        270        280        290        300 
FVFDLMYELI ELEKAYLKEL YEGFGIVEDA IKFSIYNAGK FLQNLGYDSP FTEEETRIKP 

       310        320        330 
EIFAQLSARA DENHDFFSGN GSSYVMGISE ETEDKDWDF 

« Hide

References

[1]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00089 Genomic DNA. Translation: AAB96162.1.
PIRS73840.
RefSeqNP_110010.1. NC_000912.1.

3D structure databases

ProteinModelPortalP75461.
SMRP75461. Positions 24-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP75461. 4 interactions.
STRING272634.MPN322.

Proteomic databases

PaxDbP75461.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB96162; AAB96162; MPN_322.
GeneID876942.
KEGGmpn:MPN322.
PATRIC20021998. VBIMycPne110_0346.

Phylogenomic databases

eggNOGCOG0208.
KOK00526.
OMAQSPIDYA.
OrthoDBEOG68DD19.

Enzyme and pathway databases

BioCycMPNE272634:GJ6Z-339-MONOMER.
UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026494. RNR_1b_NrdF.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
TIGRFAMsTIGR04171. RNR_1b_NrdF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRIR2_MYCPN
AccessionPrimary (citable) accession number: P75461
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 14, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names