ID   Y111_MYCPN              Reviewed;         422 AA.
AC   P75451;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   27-MAR-2024, entry version 112.
DE   RecName: Full=Uncharacterized adenine-specific methylase MPN_111;
DE            EC=2.1.1.72;
GN   OrderedLocusNames=MPN_111; ORFNames=C09_orf422, MP043;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)
OS   (Mycoplasmoides pneumoniae).
OC   Bacteria; Mycoplasmatota; Mycoplasmoidales; Mycoplasmoidaceae;
OC   Mycoplasmoides.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129 / Subtype 1;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC   -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; U00089; AAB95691.1; -; Genomic_DNA.
DR   PIR; S73369; S73369.
DR   RefSeq; NP_109799.1; NC_000912.1.
DR   RefSeq; WP_010874468.1; NC_000912.1.
DR   AlphaFoldDB; P75451; -.
DR   STRING; 272634.MPN_111; -.
DR   EnsemblBacteria; AAB95691; AAB95691; MPN_111.
DR   KEGG; mpn:MPN_111; -.
DR   PATRIC; fig|272634.6.peg.118; -.
DR   HOGENOM; CLU_650238_0_0_14; -.
DR   OrthoDB; 9800643at2; -.
DR   BioCyc; MPNE272634:G1GJ3-189-MONOMER; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF07669; Eco57I; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..422
FT                   /note="Uncharacterized adenine-specific methylase MPN_111"
FT                   /id="PRO_0000088017"
SQ   SEQUENCE   422 AA;  49062 MW;  C0AB9D9E4230BA81 CRC64;
     MNKNSGKDYE SIQGKIKSKA EIEDSVILDQ DTFQGKGEEK TKLDELIRWE AEKNDLLKLI
     DNVGNDEVFT PVETCQRMLD ELFPEDHEVW SNPDLKWLNP CDKNGVFFRE IALRLDKGLT
     KIIPDEYARK KHIMTKMLFS IGLTKFTSLM VRRTLYYCIK ANKRKTSEDE GCAIANGARF
     NNEFGNVVTP YKEHYFGKES KSKNCHFCGT NKNSKYVNSM TEEKYAYDFI HLNSDEYENY
     FKTNFGVMKF DVIIGNPPYQ LSNGSGSDGN GAKAIFQDFV LKAIDLEPKY LAMIIPAKWM
     ISAENIFLNL RDKLKKNKDI KEINIFFDSK DCFPKREIKG GICYFIWQNN YQGKTLINTK
     FSKKGKSTEI DSSKRNLFVS VLNNTEQIIF RKRIWQDIYT KIDSISASEM KNTHTEREQF
     RS
//