P75451 (Y111_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized adenine-specific methylase MPN_111
EC=2.1.1.72

Gene names

Ordered Locus Names:	MPN_111
ORF Names:	C09_orf422, MP043

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma pneumoniae

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.
Sequence similarities	Belongs to the N(4)/N(6)-methyltransferase family.

Ontologies

Keywords
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA methylation on adenine Inferred from electronic annotation. Source: GOC
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro site-specific DNA-methyltransferase (adenine-specific) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 422	422	Uncharacterized adenine-specific methylase MPN_111		PRO_0000088017

Sequences

	Sequence		Length	Mass (Da)
	P75451 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: C0AB9D9E4230BA81	FASTA	422	49,062
	10 20 30 40 50 60 MNKNSGKDYE SIQGKIKSKA EIEDSVILDQ DTFQGKGEEK TKLDELIRWE AEKNDLLKLI 70 80 90 100 110 120 DNVGNDEVFT PVETCQRMLD ELFPEDHEVW SNPDLKWLNP CDKNGVFFRE IALRLDKGLT 130 140 150 160 170 180 KIIPDEYARK KHIMTKMLFS IGLTKFTSLM VRRTLYYCIK ANKRKTSEDE GCAIANGARF 190 200 210 220 230 240 NNEFGNVVTP YKEHYFGKES KSKNCHFCGT NKNSKYVNSM TEEKYAYDFI HLNSDEYENY 250 260 270 280 290 300 FKTNFGVMKF DVIIGNPPYQ LSNGSGSDGN GAKAIFQDFV LKAIDLEPKY LAMIIPAKWM 310 320 330 340 350 360 ISAENIFLNL RDKLKKNKDI KEINIFFDSK DCFPKREIKG GICYFIWQNN YQGKTLINTK 370 380 390 400 410 420 FSKKGKSTEI DSSKRNLFVS VLNNTEQIIF RKRIWQDIYT KIDSISASEM KNTHTEREQF RS

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB95691.1.
PIR	S73369.
RefSeq	NP_109799.1. NC_000912.1.
3D structure databases
ModBase	Search...
Protein family/group databases
REBASE	27679. MpnORF111P.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB95691; AAB95691; MPN_111.
GeneID	877256.
KEGG	mpn:MPN111.
PATRIC	20021521. VBIMycPne110_0118.
Phylogenomic databases
eggNOG	COG0827.
KO	K00571.
OMA	NTHTERE.
ProtClustDB	CLSK407652.
Enzyme and pathway databases
BioCyc	MPNE272634:GJ6Z-117-MONOMER.
Family and domain databases
InterPro	IPR002052. DNA_methylase_N6_adenine_CS. IPR011639. RM_methylase_Eco57I. [Graphical view]
Pfam	PF07669. Eco57I. 1 hit. [Graphical view]
PROSITE	PS00092. N6_MTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y111_MYCPN

Accession

Primary (citable) accession number: P75451

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program