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P75436 (T1MD_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative type I restriction enzyme MpnORFDP M protein

Short name=M.MpnORFDP
EC=2.1.1.72
Gene names
Ordered Locus Names:MPN_342
ORF Names:H91_orf543, MP494
OrganismMycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]
Taxonomic identifier272634 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length543 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Methylation of specific adenine residues; required for both restriction and modification activities By similarity.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Subunit structure

The type I restriction/modification system is composed of three polypeptides R, M and S.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 543543Putative type I restriction enzyme MpnORFDP M protein
PRO_0000088028

Regions

Region208 – 2136S-adenosyl-L-methionine binding By similarity
Region240 – 2423S-adenosyl-L-methionine binding By similarity

Sites

Binding site2651S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
P75436 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 618EE22B4FE03064

FASTA54361,975
        10         20         30         40         50         60 
MEKKRTEQRN GVEKKIWEIA DKLRGTIDGW DFKSYVLIGL FYRFLSENLC KYFNDSERRN 

        70         80         90        100        110        120 
NPDFSYENLT DDYEAIDALK DAAIASKGFF IKPSQLFQNV VKSIRENKNN EDLNTTLRDI 

       130        140        150        160        170        180 
FDDIEKSTEL GDGRSKESFK GLFKDFNVSE VKLGSTLTIR TEKLKELLTS IDTMELDEFE 

       190        200        210        220        230        240 
KNSIDAFGDA YEFLISMYAQ NAGKSGGEFF TPQDISELLA RIAIGKKDTV DDVYDMACGS 

       250        260        270        280        290        300 
GSLLLQVIKV LGKEKTSLVS YYGQEINHTT YNLCRMNMIL HNIDYANFNI INADTLTTKE 

       310        320        330        340        350        360 
WEKHYVNCSN ENGFEVVVSN PPYSISWAGD KKSNLVSDVR FKDAGTLAPN SKADLAFVLH 

       370        380        390        400        410        420 
ALYVLGQEGT AAIVCFPGIL YREGKEQTIR KYLVDQNFVD AVIQLPSNLF STTSIATSIL 

       430        440        450        460        470        480 
VLKKNRDKKD PIFFIDGSNE FVREKKNNRL SPKNIEKIVD CFNSKKEEAN FAKSVERDKI 

       490        500        510        520        530        540 
RESNYDLTVG KYVNSEAEKE ELDIKVLNHS IDEIVDKQKD LRTKIKDIIQ DIKVDFDNID 


INN 

« Hide

References

[1]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00089 Genomic DNA. Translation: AAB96142.1.
PIRS73820.
RefSeqNP_110030.1. NC_000912.1.

3D structure databases

ProteinModelPortalP75436.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP75436. 2 interactions.
STRING272634.MPN342.

Protein family/group databases

REBASE6703. M.MpnII.

Proteomic databases

PaxDbP75436.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB96142; AAB96142; MPN_342.
GeneID876775.
KEGGmpn:MPN342.
PATRIC20022038. VBIMycPne110_0366.

Phylogenomic databases

eggNOGCOG0286.
KOK03427.
OMAITPEIKD.
OrthoDBEOG64JFNB.

Enzyme and pathway databases

BioCycMPNE272634:GJ6Z-359-MONOMER.

Family and domain databases

InterProIPR022749. D12N6_MeTrfase_N.
IPR003356. DNA_methylase_A-5.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
IPR004546. Restrct_endonuc_typeI_HsdM.
[Graphical view]
PfamPF12161. HsdM_N. 1 hit.
PF02384. N6_Mtase. 1 hit.
[Graphical view]
PRINTSPR00507. N12N6MTFRASE.
TIGRFAMsTIGR00497. hsdM. 1 hit.
PROSITEPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameT1MD_MYCPN
AccessionPrimary (citable) accession number: P75436
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: November 13, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names