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P75436

- T1MD_MYCPN

UniProt

P75436 - T1MD_MYCPN

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Protein
Putative type I restriction enzyme MpnORFDP M protein
Gene
MPN_342, H91_orf543, MP494
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Methylation of specific adenine residues; required for both restriction and modification activities By similarity.

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei265 – 2651S-adenosyl-L-methionine By similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. N-methyltransferase activity Source: InterPro
  3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-359-MONOMER.

Protein family/group databases

REBASEi6703. M.MpnII.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type I restriction enzyme MpnORFDP M protein (EC:2.1.1.72)
Short name:
M.MpnORFDP
Gene namesi
Ordered Locus Names:MPN_342
ORF Names:H91_orf543, MP494
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Putative type I restriction enzyme MpnORFDP M protein
PRO_0000088028Add
BLAST

Proteomic databases

PaxDbiP75436.

Interactioni

Subunit structurei

The type I restriction/modification system is composed of three polypeptides R, M and S.

Protein-protein interaction databases

IntActiP75436. 2 interactions.
STRINGi272634.MPN342.

Structurei

3D structure databases

ProteinModelPortaliP75436.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni208 – 2136S-adenosyl-L-methionine binding By similarity
Regioni240 – 2423S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0286.
KOiK03427.
OMAiYSAHWNN.
OrthoDBiEOG64JFNB.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR022749. D12N6_MeTrfase_N.
IPR003356. DNA_methylase_A-5.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
IPR004546. Restrct_endonuc_typeI_HsdM.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF12161. HsdM_N. 1 hit.
PF02384. N6_Mtase. 1 hit.
[Graphical view]
PRINTSiPR00507. N12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00497. hsdM. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75436-1 [UniParc]FASTAAdd to Basket

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MEKKRTEQRN GVEKKIWEIA DKLRGTIDGW DFKSYVLIGL FYRFLSENLC    50
KYFNDSERRN NPDFSYENLT DDYEAIDALK DAAIASKGFF IKPSQLFQNV 100
VKSIRENKNN EDLNTTLRDI FDDIEKSTEL GDGRSKESFK GLFKDFNVSE 150
VKLGSTLTIR TEKLKELLTS IDTMELDEFE KNSIDAFGDA YEFLISMYAQ 200
NAGKSGGEFF TPQDISELLA RIAIGKKDTV DDVYDMACGS GSLLLQVIKV 250
LGKEKTSLVS YYGQEINHTT YNLCRMNMIL HNIDYANFNI INADTLTTKE 300
WEKHYVNCSN ENGFEVVVSN PPYSISWAGD KKSNLVSDVR FKDAGTLAPN 350
SKADLAFVLH ALYVLGQEGT AAIVCFPGIL YREGKEQTIR KYLVDQNFVD 400
AVIQLPSNLF STTSIATSIL VLKKNRDKKD PIFFIDGSNE FVREKKNNRL 450
SPKNIEKIVD CFNSKKEEAN FAKSVERDKI RESNYDLTVG KYVNSEAEKE 500
ELDIKVLNHS IDEIVDKQKD LRTKIKDIIQ DIKVDFDNID INN 543
Length:543
Mass (Da):61,975
Last modified:February 1, 1997 - v1
Checksum:i618EE22B4FE03064
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB96142.1.
PIRiS73820.
RefSeqiNP_110030.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96142; AAB96142; MPN_342.
GeneIDi876775.
KEGGimpn:MPN342.
PATRICi20022038. VBIMycPne110_0366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB96142.1 .
PIRi S73820.
RefSeqi NP_110030.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75436.
ModBasei Search...

Protein-protein interaction databases

IntActi P75436. 2 interactions.
STRINGi 272634.MPN342.

Protein family/group databases

REBASEi 6703. M.MpnII.

Proteomic databases

PaxDbi P75436.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB96142 ; AAB96142 ; MPN_342 .
GeneIDi 876775.
KEGGi mpn:MPN342.
PATRICi 20022038. VBIMycPne110_0366.

Phylogenomic databases

eggNOGi COG0286.
KOi K03427.
OMAi YSAHWNN.
OrthoDBi EOG64JFNB.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-359-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR022749. D12N6_MeTrfase_N.
IPR003356. DNA_methylase_A-5.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
IPR004546. Restrct_endonuc_typeI_HsdM.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF12161. HsdM_N. 1 hit.
PF02384. N6_Mtase. 1 hit.
[Graphical view ]
PRINTSi PR00507. N12N6MTFRASE.
SUPFAMi SSF53335. SSF53335. 2 hits.
TIGRFAMsi TIGR00497. hsdM. 1 hit.
PROSITEi PS00092. N6_MTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiT1MD_MYCPN
AccessioniPrimary (citable) accession number: P75436
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi