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P75436

- T1MD_MYCPN

UniProt

P75436 - T1MD_MYCPN

Protein

Putative type I restriction enzyme MpnORFDP M protein

Gene

MPN_342

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Methylation of specific adenine residues; required for both restriction and modification activities.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei265 – 2651S-adenosyl-L-methionineBy similarity

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. N-methyltransferase activity Source: InterPro
    3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-359-MONOMER.

    Protein family/group databases

    REBASEi6703. M.MpnII.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative type I restriction enzyme MpnORFDP M protein (EC:2.1.1.72)
    Short name:
    M.MpnORFDP
    Gene namesi
    Ordered Locus Names:MPN_342
    ORF Names:H91_orf543, MP494
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 543543Putative type I restriction enzyme MpnORFDP M proteinPRO_0000088028Add
    BLAST

    Proteomic databases

    PaxDbiP75436.

    Interactioni

    Subunit structurei

    The type I restriction/modification system is composed of three polypeptides R, M and S.

    Protein-protein interaction databases

    IntActiP75436. 2 interactions.
    STRINGi272634.MPN342.

    Structurei

    3D structure databases

    ProteinModelPortaliP75436.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni208 – 2136S-adenosyl-L-methionine bindingBy similarity
    Regioni240 – 2423S-adenosyl-L-methionine bindingBy similarity

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0286.
    KOiK03427.
    OMAiYSAHWNN.
    OrthoDBiEOG64JFNB.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR022749. D12N6_MeTrfase_N.
    IPR003356. DNA_methylase_A-5.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR004546. Restrct_endonuc_typeI_HsdM.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF12161. HsdM_N. 1 hit.
    PF02384. N6_Mtase. 1 hit.
    [Graphical view]
    PRINTSiPR00507. N12N6MTFRASE.
    SUPFAMiSSF53335. SSF53335. 2 hits.
    TIGRFAMsiTIGR00497. hsdM. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P75436-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKKRTEQRN GVEKKIWEIA DKLRGTIDGW DFKSYVLIGL FYRFLSENLC    50
    KYFNDSERRN NPDFSYENLT DDYEAIDALK DAAIASKGFF IKPSQLFQNV 100
    VKSIRENKNN EDLNTTLRDI FDDIEKSTEL GDGRSKESFK GLFKDFNVSE 150
    VKLGSTLTIR TEKLKELLTS IDTMELDEFE KNSIDAFGDA YEFLISMYAQ 200
    NAGKSGGEFF TPQDISELLA RIAIGKKDTV DDVYDMACGS GSLLLQVIKV 250
    LGKEKTSLVS YYGQEINHTT YNLCRMNMIL HNIDYANFNI INADTLTTKE 300
    WEKHYVNCSN ENGFEVVVSN PPYSISWAGD KKSNLVSDVR FKDAGTLAPN 350
    SKADLAFVLH ALYVLGQEGT AAIVCFPGIL YREGKEQTIR KYLVDQNFVD 400
    AVIQLPSNLF STTSIATSIL VLKKNRDKKD PIFFIDGSNE FVREKKNNRL 450
    SPKNIEKIVD CFNSKKEEAN FAKSVERDKI RESNYDLTVG KYVNSEAEKE 500
    ELDIKVLNHS IDEIVDKQKD LRTKIKDIIQ DIKVDFDNID INN 543
    Length:543
    Mass (Da):61,975
    Last modified:February 1, 1997 - v1
    Checksum:i618EE22B4FE03064
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96142.1.
    PIRiS73820.
    RefSeqiNP_110030.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB96142; AAB96142; MPN_342.
    GeneIDi876775.
    KEGGimpn:MPN342.
    PATRICi20022038. VBIMycPne110_0366.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96142.1 .
    PIRi S73820.
    RefSeqi NP_110030.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75436.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P75436. 2 interactions.
    STRINGi 272634.MPN342.

    Protein family/group databases

    REBASEi 6703. M.MpnII.

    Proteomic databases

    PaxDbi P75436.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB96142 ; AAB96142 ; MPN_342 .
    GeneIDi 876775.
    KEGGi mpn:MPN342.
    PATRICi 20022038. VBIMycPne110_0366.

    Phylogenomic databases

    eggNOGi COG0286.
    KOi K03427.
    OMAi YSAHWNN.
    OrthoDBi EOG64JFNB.

    Enzyme and pathway databases

    BioCyci MPNE272634:GJ6Z-359-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR022749. D12N6_MeTrfase_N.
    IPR003356. DNA_methylase_A-5.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR004546. Restrct_endonuc_typeI_HsdM.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF12161. HsdM_N. 1 hit.
    PF02384. N6_Mtase. 1 hit.
    [Graphical view ]
    PRINTSi PR00507. N12N6MTFRASE.
    SUPFAMi SSF53335. SSF53335. 2 hits.
    TIGRFAMsi TIGR00497. hsdM. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiT1MD_MYCPN
    AccessioniPrimary (citable) accession number: P75436
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3