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P75400

- COAE_MYCPN

UniProt

P75400 - COAE_MYCPN

Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.By similarity

    Catalytic activityi

    ATP + 3'-dephospho-CoA = ADP + CoA.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 148ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. dephospho-CoA kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. coenzyme A biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Coenzyme A biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-403-MONOMER.
    UniPathwayiUPA00241; UER00356.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dephospho-CoA kinase (EC:2.7.1.24)
    Alternative name(s):
    Dephosphocoenzyme A kinase
    Gene namesi
    Name:coaE
    Ordered Locus Names:MPN_382
    ORF Names:MP455
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 200200Dephospho-CoA kinasePRO_0000172962Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272634.MPN382.

    Structurei

    3D structure databases

    ProteinModelPortaliP75400.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 200199DPCKAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CoaE family.Curated

    Phylogenomic databases

    eggNOGiCOG0237.
    KOiK00859.
    OMAiAVMLNYW.
    OrthoDBiEOG6TR0JH.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00376. Dephospho_CoA_kinase.
    InterProiIPR001977. Depp_CoAkinase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01121. CoaE. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
    PROSITEiPS51219. DPCK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P75400-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLIAVVGKAG VGKTTVLQYI ADYFHFPVFF ADRFIHQQYA NGQAGYAIVK    50
    QQFGAQFVNH EAVDRKQLAQ YVFNQPDELK RLSNLTKPLV QEWLNQLKAQ 100
    FQDKIALVEI AVMLNYWNDY RPFFDEVIQI ERDAKIVKQA LKARGVDVEQ 150
    VQKLIADPTY PILTVINNST VAECALHVTQ FLESIAKSDK CHHGHYQTPK 200
    Length:200
    Mass (Da):22,910
    Last modified:February 1, 1997 - v1
    Checksum:i396EA0C4AA940589
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96103.1.
    PIRiS73781.
    RefSeqiNP_110070.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB96103; AAB96103; MPN_382.
    GeneIDi877392.
    KEGGimpn:MPN382.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96103.1 .
    PIRi S73781.
    RefSeqi NP_110070.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75400.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272634.MPN382.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB96103 ; AAB96103 ; MPN_382 .
    GeneIDi 877392.
    KEGGi mpn:MPN382.

    Phylogenomic databases

    eggNOGi COG0237.
    KOi K00859.
    OMAi AVMLNYW.
    OrthoDBi EOG6TR0JH.

    Enzyme and pathway databases

    UniPathwayi UPA00241 ; UER00356 .
    BioCyci MPNE272634:GJ6Z-403-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00376. Dephospho_CoA_kinase.
    InterProi IPR001977. Depp_CoAkinase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01121. CoaE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00152. TIGR00152. 1 hit.
    PROSITEi PS51219. DPCK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiCOAE_MYCPN
    AccessioniPrimary (citable) accession number: P75400
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3