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P75400

- COAE_MYCPN

UniProt

P75400 - COAE_MYCPN

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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.By similarity

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 148ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. dephospho-CoA kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. coenzyme A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-403-MONOMER.
UniPathwayiUPA00241; UER00356.

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinase (EC:2.7.1.24)
Alternative name(s):
Dephosphocoenzyme A kinase
Gene namesi
Name:coaE
Ordered Locus Names:MPN_382
ORF Names:MP455
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Dephospho-CoA kinasePRO_0000172962Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272634.MPN382.

Structurei

3D structure databases

ProteinModelPortaliP75400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 200199DPCKAdd
BLAST

Sequence similaritiesi

Belongs to the CoaE family.Curated

Phylogenomic databases

eggNOGiCOG0237.
KOiK00859.
OMAiAVMLNYW.
OrthoDBiEOG6TR0JH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75400-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLIAVVGKAG VGKTTVLQYI ADYFHFPVFF ADRFIHQQYA NGQAGYAIVK
60 70 80 90 100
QQFGAQFVNH EAVDRKQLAQ YVFNQPDELK RLSNLTKPLV QEWLNQLKAQ
110 120 130 140 150
FQDKIALVEI AVMLNYWNDY RPFFDEVIQI ERDAKIVKQA LKARGVDVEQ
160 170 180 190 200
VQKLIADPTY PILTVINNST VAECALHVTQ FLESIAKSDK CHHGHYQTPK
Length:200
Mass (Da):22,910
Last modified:February 1, 1997 - v1
Checksum:i396EA0C4AA940589
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB96103.1.
PIRiS73781.
RefSeqiNP_110070.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96103; AAB96103; MPN_382.
GeneIDi877392.
KEGGimpn:MPN382.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB96103.1 .
PIRi S73781.
RefSeqi NP_110070.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75400.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272634.MPN382.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB96103 ; AAB96103 ; MPN_382 .
GeneIDi 877392.
KEGGi mpn:MPN382.

Phylogenomic databases

eggNOGi COG0237.
KOi K00859.
OMAi AVMLNYW.
OrthoDBi EOG6TR0JH.

Enzyme and pathway databases

UniPathwayi UPA00241 ; UER00356 .
BioCyci MPNE272634:GJ6Z-403-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00376. Dephospho_CoA_kinase.
InterProi IPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01121. CoaE. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00152. TIGR00152. 1 hit.
PROSITEi PS51219. DPCK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiCOAE_MYCPN
AccessioniPrimary (citable) accession number: P75400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3