Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P75391

- ODPB_MYCPN

UniProt

P75391 - ODPB_MYCPN

Protein

Pyruvate dehydrogenase E1 component subunit beta

Gene

pdhB

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei63 – 631Thiamine pyrophosphateBy similarity

    GO - Molecular functioni

    1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Pyruvate, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-587.
    MPNE272634:GJ6Z-415-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 component subunit beta (EC:1.2.4.1)
    Gene namesi
    Name:pdhB
    Ordered Locus Names:MPN_392
    ORF Names:MP446
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Pyruvate dehydrogenase E1 component subunit betaPRO_0000162224Add
    BLAST

    Proteomic databases

    PaxDbiP75391.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.By similarity

    Protein-protein interaction databases

    IntActiP75391. 3 interactions.
    STRINGi272634.MPN392.

    Structurei

    3D structure databases

    ProteinModelPortaliP75391.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0022.
    KOiK00162.
    OMAiFTCPLVV.
    OrthoDBiEOG6JQH4C.

    Family and domain databases

    Gene3Di3.40.50.920. 1 hit.
    3.40.50.970. 1 hit.
    InterProiIPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR005476. Transketolase_C.
    [Graphical view]
    PfamiPF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view]
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 1 hit.
    SSF52922. SSF52922. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P75391-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKTIQANNI EALGNAMDLA LERDPNVVLY GQDAGFEGGV FRATKGLQKK    50
    YGEERVWDCP IAEAAMAGIG VGAAIGGLKP IVEIQFSGFS FPAMFQIFTH 100
    AARIRNRSRG VYTCPIIVRM PMGGGIKALE HHSETLEAIY GQIAGLKTVM 150
    PSNPYDTKGL FLAAVESPDP VVFFEPKKLY RAFRQEIPAD YYTVPIGQAN 200
    LISQGNNLTI VSYGPTMFDL INMVYGGELK DKGIELIDLR TISPWDKETV 250
    FNSVKKTGRL LVVTEAAKTF TTSGEIIASV TEELFSYLKA APQRVTGWDI 300
    VVPLARGEHY QFNLNARILE AVNQLLK 327
    Length:327
    Mass (Da):35,914
    Last modified:February 1, 1997 - v1
    Checksum:i06513520FDAFED54
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96094.1.
    PIRiS73772.
    RefSeqiNP_110080.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB96094; AAB96094; MPN_392.
    GeneIDi877125.
    KEGGimpn:MPN392.
    PATRICi20022160. VBIMycPne110_0423.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96094.1 .
    PIRi S73772.
    RefSeqi NP_110080.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75391.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P75391. 3 interactions.
    STRINGi 272634.MPN392.

    Proteomic databases

    PaxDbi P75391.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB96094 ; AAB96094 ; MPN_392 .
    GeneIDi 877125.
    KEGGi mpn:MPN392.
    PATRICi 20022160. VBIMycPne110_0423.

    Phylogenomic databases

    eggNOGi COG0022.
    KOi K00162.
    OMAi FTCPLVV.
    OrthoDBi EOG6JQH4C.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-587.
    MPNE272634:GJ6Z-415-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.920. 1 hit.
    3.40.50.970. 1 hit.
    InterProi IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR005476. Transketolase_C.
    [Graphical view ]
    Pfami PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 1 hit.
    SSF52922. SSF52922. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiODPB_MYCPN
    AccessioniPrimary (citable) accession number: P75391
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names

    External Data

    Dasty 3