Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P75391

- ODPB_MYCPN

UniProt

P75391 - ODPB_MYCPN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Pyruvate dehydrogenase E1 component subunit beta

Gene

pdhB

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631Thiamine pyrophosphateBy similarity

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-587.
MPNE272634:GJ6Z-415-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta (EC:1.2.4.1)
Gene namesi
Name:pdhB
Ordered Locus Names:MPN_392
ORF Names:MP446
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Pyruvate dehydrogenase E1 component subunit betaPRO_0000162224Add
BLAST

Proteomic databases

PaxDbiP75391.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.By similarity

Protein-protein interaction databases

IntActiP75391. 3 interactions.
STRINGi272634.MPN392.

Structurei

3D structure databases

ProteinModelPortaliP75391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0022.
KOiK00162.
OMAiFTCPLVV.
OrthoDBiEOG6JQH4C.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProiIPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view]
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.

Sequencei

Sequence statusi: Complete.

P75391-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKTIQANNI EALGNAMDLA LERDPNVVLY GQDAGFEGGV FRATKGLQKK
60 70 80 90 100
YGEERVWDCP IAEAAMAGIG VGAAIGGLKP IVEIQFSGFS FPAMFQIFTH
110 120 130 140 150
AARIRNRSRG VYTCPIIVRM PMGGGIKALE HHSETLEAIY GQIAGLKTVM
160 170 180 190 200
PSNPYDTKGL FLAAVESPDP VVFFEPKKLY RAFRQEIPAD YYTVPIGQAN
210 220 230 240 250
LISQGNNLTI VSYGPTMFDL INMVYGGELK DKGIELIDLR TISPWDKETV
260 270 280 290 300
FNSVKKTGRL LVVTEAAKTF TTSGEIIASV TEELFSYLKA APQRVTGWDI
310 320
VVPLARGEHY QFNLNARILE AVNQLLK
Length:327
Mass (Da):35,914
Last modified:February 1, 1997 - v1
Checksum:i06513520FDAFED54
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB96094.1.
PIRiS73772.
RefSeqiNP_110080.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96094; AAB96094; MPN_392.
GeneIDi877125.
KEGGimpn:MPN392.
PATRICi20022160. VBIMycPne110_0423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB96094.1 .
PIRi S73772.
RefSeqi NP_110080.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75391.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P75391. 3 interactions.
STRINGi 272634.MPN392.

Proteomic databases

PaxDbi P75391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB96094 ; AAB96094 ; MPN_392 .
GeneIDi 877125.
KEGGi mpn:MPN392.
PATRICi 20022160. VBIMycPne110_0423.

Phylogenomic databases

eggNOGi COG0022.
KOi K00162.
OMAi FTCPLVV.
OrthoDBi EOG6JQH4C.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-587.
MPNE272634:GJ6Z-415-MONOMER.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProi IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view ]
Pfami PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view ]
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiODPB_MYCPN
AccessioniPrimary (citable) accession number: P75391
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 1, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names

External Data

Dasty 3