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P75390

- ODPA_MYCPN

UniProt

P75390 - ODPA_MYCPN

Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Pyruvate, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-586.
    MPNE272634:GJ6Z-416-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
    Gene namesi
    Name:pdhA
    Ordered Locus Names:MPN_393
    ORF Names:MP445
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Pyruvate dehydrogenase E1 component subunit alphaPRO_0000162201Add
    BLAST

    Proteomic databases

    PaxDbiP75390.

    PTM databases

    PhosSiteiP1011998.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.

    Protein-protein interaction databases

    IntActiP75390. 3 interactions.
    STRINGi272634.MPN393.

    Structurei

    3D structure databases

    ProteinModelPortaliP75390.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1071.
    KOiK00161.
    OMAiNNGYAIT.
    OrthoDBiEOG6VMTKR.

    Family and domain databases

    Gene3Di3.40.50.970. 1 hit.
    InterProiIPR001017. DH_E1.
    IPR017596. PdhA/BkdA.
    IPR029061. THDP-binding.
    [Graphical view]
    PfamiPF00676. E1_dh. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 1 hit.
    TIGRFAMsiTIGR03181. PDH_E1_alph_x. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P75390-1 [UniParc]FASTAAdd to Basket

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    MAILIKNKVP TTLYQVYDNE GKLMDPNHKI TLSNEQLKHA FYLMNLSRIM    50
    DKKMLVWQRA GKMLNFAPNL GEEALQVGMG MGLNENDWFC PTFRSGALML 100
    YRGVKPEQLL LYWNGNENGS KIEAKYKTLP INITIGAQYS HAAGLGYMLH 150
    YKKLPNVAVT MIGDGGTAEG EFYEAMNIAS IHKWNSVFCI NNNQFAISTR 200
    TKLESAVSDL STKAIAVNIP RIRVDGNDLI ASYEAMHEAA NYARSGNGPV 250
    LIEFFSWRQG PHTTSDDPSI YRTKEEEAEA MKSDPVKRLR NFLFDRGILT 300
    PQQEEEMVAK IEQEVQAAYE VMVSKTPVTL DEVFDYNYEK LTPDLARQKA 350
    EAKKYFKD 358
    Length:358
    Mass (Da):40,594
    Last modified:February 1, 1997 - v1
    Checksum:iE6184A2026D7A143
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96093.1.
    PIRiS73771.
    RefSeqiNP_110081.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB96093; AAB96093; MPN_393.
    GeneIDi877083.
    KEGGimpn:MPN393.
    PATRICi20022162. VBIMycPne110_0424.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96093.1 .
    PIRi S73771.
    RefSeqi NP_110081.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75390.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P75390. 3 interactions.
    STRINGi 272634.MPN393.

    PTM databases

    PhosSitei P1011998.

    Proteomic databases

    PaxDbi P75390.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB96093 ; AAB96093 ; MPN_393 .
    GeneIDi 877083.
    KEGGi mpn:MPN393.
    PATRICi 20022162. VBIMycPne110_0424.

    Phylogenomic databases

    eggNOGi COG1071.
    KOi K00161.
    OMAi NNGYAIT.
    OrthoDBi EOG6VMTKR.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-586.
    MPNE272634:GJ6Z-416-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 1 hit.
    InterProi IPR001017. DH_E1.
    IPR017596. PdhA/BkdA.
    IPR029061. THDP-binding.
    [Graphical view ]
    Pfami PF00676. E1_dh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 1 hit.
    TIGRFAMsi TIGR03181. PDH_E1_alph_x. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiODPA_MYCPN
    AccessioniPrimary (citable) accession number: P75390
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names

    External Data

    Dasty 3