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P75390 (ODPA_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component subunit alpha
EC=1.2.4.1
Gene names
Name:pdhA
Ordered Locus Names:MPN_393
ORF Names:MP445
OrganismMycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]
Taxonomic identifier272634 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma ›

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Subunit structure

Heterodimer of an alpha and a beta chain.

Ontologies

Keywords
   Biological processGlycolysis
   LigandPyruvate
Thiamine pyrophosphate
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionpyruvate dehydrogenase (acetyl-transferring) activity

Inferred from electronic annotation. Source: EC

thiamine pyrophosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Pyruvate dehydrogenase E1 component subunit alpha
PRO_0000162201

Sequences

Sequence LengthMass (Da)Tools
P75390 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: E6184A2026D7A143

FASTA35840,594
        10         20         30         40         50         60 
MAILIKNKVP TTLYQVYDNE GKLMDPNHKI TLSNEQLKHA FYLMNLSRIM DKKMLVWQRA 

        70         80         90        100        110        120 
GKMLNFAPNL GEEALQVGMG MGLNENDWFC PTFRSGALML YRGVKPEQLL LYWNGNENGS 

       130        140        150        160        170        180 
KIEAKYKTLP INITIGAQYS HAAGLGYMLH YKKLPNVAVT MIGDGGTAEG EFYEAMNIAS 

       190        200        210        220        230        240 
IHKWNSVFCI NNNQFAISTR TKLESAVSDL STKAIAVNIP RIRVDGNDLI ASYEAMHEAA 

       250        260        270        280        290        300 
NYARSGNGPV LIEFFSWRQG PHTTSDDPSI YRTKEEEAEA MKSDPVKRLR NFLFDRGILT 

       310        320        330        340        350 
PQQEEEMVAK IEQEVQAAYE VMVSKTPVTL DEVFDYNYEK LTPDLARQKA EAKKYFKD

« Hide

References

[1]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U00089 Genomic DNA. Translation: AAB96093.1.
PIRS73771.
RefSeqNP_110081.1. NC_000912.1.

3D structure databases

ProteinModelPortalP75390.
ModBaseSearch...

Protein-protein interaction databases

IntActP75390. 3 interactions.
STRING272634.MPN393.

PTM databases

PhosSiteP1011998.

Proteomic databases

PaxDbP75390.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB96093; AAB96093; MPN_393.
GeneID877083.
KEGGmpn:MPN393.
PATRIC20022162. VBIMycPne110_0424.

Phylogenomic databases

eggNOGCOG1071.
KOK00161.
OMAKEEEAKW.
ProtClustDBCLSK390576.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-586.
MPNE272634:GJ6Z-416-MONOMER.

Family and domain databases

InterProIPR001017. DH_E1.
IPR017596. Pyrv_DH_E1_asu_subgrp-x.
[Graphical view]
PfamPF00676. E1_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03181. PDH_E1_alph_x. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODPA_MYCPN
AccessionPrimary (citable) accession number: P75390
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names

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