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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-586.
MPNE272634:GJ6Z-416-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Ordered Locus Names:MPN_393
ORF Names:MP445
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Pyruvate dehydrogenase E1 component subunit alphaPRO_0000162201Add
BLAST

Proteomic databases

PaxDbiP75390.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

IntActiP75390. 3 interactions.
STRINGi272634.MPN393.

Structurei

3D structure databases

ProteinModelPortaliP75390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1071.
KOiK00161.
OMAiDFYEAMN.
OrthoDBiEOG6VMTKR.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017596. PdhA/BkdA.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03181. PDH_E1_alph_x. 1 hit.

Sequencei

Sequence statusi: Complete.

P75390-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAILIKNKVP TTLYQVYDNE GKLMDPNHKI TLSNEQLKHA FYLMNLSRIM
60 70 80 90 100
DKKMLVWQRA GKMLNFAPNL GEEALQVGMG MGLNENDWFC PTFRSGALML
110 120 130 140 150
YRGVKPEQLL LYWNGNENGS KIEAKYKTLP INITIGAQYS HAAGLGYMLH
160 170 180 190 200
YKKLPNVAVT MIGDGGTAEG EFYEAMNIAS IHKWNSVFCI NNNQFAISTR
210 220 230 240 250
TKLESAVSDL STKAIAVNIP RIRVDGNDLI ASYEAMHEAA NYARSGNGPV
260 270 280 290 300
LIEFFSWRQG PHTTSDDPSI YRTKEEEAEA MKSDPVKRLR NFLFDRGILT
310 320 330 340 350
PQQEEEMVAK IEQEVQAAYE VMVSKTPVTL DEVFDYNYEK LTPDLARQKA

EAKKYFKD
Length:358
Mass (Da):40,594
Last modified:February 1, 1997 - v1
Checksum:iE6184A2026D7A143
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB96093.1.
PIRiS73771.
RefSeqiNP_110081.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96093; AAB96093; MPN_393.
GeneIDi877083.
KEGGimpn:MPN393.
PATRICi20022162. VBIMycPne110_0424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB96093.1.
PIRiS73771.
RefSeqiNP_110081.1. NC_000912.1.

3D structure databases

ProteinModelPortaliP75390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP75390. 3 interactions.
STRINGi272634.MPN393.

Proteomic databases

PaxDbiP75390.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB96093; AAB96093; MPN_393.
GeneIDi877083.
KEGGimpn:MPN393.
PATRICi20022162. VBIMycPne110_0424.

Phylogenomic databases

eggNOGiCOG1071.
KOiK00161.
OMAiDFYEAMN.
OrthoDBiEOG6VMTKR.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-586.
MPNE272634:GJ6Z-416-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017596. PdhA/BkdA.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03181. PDH_E1_alph_x. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiODPA_MYCPN
AccessioniPrimary (citable) accession number: P75390
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 4, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.