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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-586
MPNE272634:G1GJ3-623-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Ordered Locus Names:MPN_393
ORF Names:MP445
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000808 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: AgBase
  • cytosol Source: AgBase
  • membrane Source: AgBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001622011 – 358Pyruvate dehydrogenase E1 component subunit alphaAdd BLAST358

Proteomic databases

PRIDEiP75390

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiP75390, 7 interactors

Structurei

3D structure databases

ProteinModelPortaliP75390
SMRiP75390
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK00161
OMAiNTMDKIL

Family and domain databases

InterProiView protein in InterPro
IPR001017 DH_E1
IPR017596 PdhA/BkdA
IPR029061 THDP-binding
PANTHERiPTHR11516:SF41 PTHR11516:SF41, 1 hit
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
TIGRFAMsiTIGR03181 PDH_E1_alph_x, 1 hit

Sequencei

Sequence statusi: Complete.

P75390-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAILIKNKVP TTLYQVYDNE GKLMDPNHKI TLSNEQLKHA FYLMNLSRIM
60 70 80 90 100
DKKMLVWQRA GKMLNFAPNL GEEALQVGMG MGLNENDWFC PTFRSGALML
110 120 130 140 150
YRGVKPEQLL LYWNGNENGS KIEAKYKTLP INITIGAQYS HAAGLGYMLH
160 170 180 190 200
YKKLPNVAVT MIGDGGTAEG EFYEAMNIAS IHKWNSVFCI NNNQFAISTR
210 220 230 240 250
TKLESAVSDL STKAIAVNIP RIRVDGNDLI ASYEAMHEAA NYARSGNGPV
260 270 280 290 300
LIEFFSWRQG PHTTSDDPSI YRTKEEEAEA MKSDPVKRLR NFLFDRGILT
310 320 330 340 350
PQQEEEMVAK IEQEVQAAYE VMVSKTPVTL DEVFDYNYEK LTPDLARQKA

EAKKYFKD
Length:358
Mass (Da):40,594
Last modified:February 1, 1997 - v1
Checksum:iE6184A2026D7A143
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA Translation: AAB96093.1
PIRiS73771
RefSeqiNP_110081.1, NC_000912.1
WP_010874749.1, NC_000912.1

Genome annotation databases

EnsemblBacteriaiAAB96093; AAB96093; MPN_393
GeneIDi877083
KEGGimpn:MPN393
PATRICifig|272634.6.peg.424

Similar proteinsi

Entry informationi

Entry nameiODPA_MYCPN
AccessioniPrimary (citable) accession number: P75390
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names

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