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Reviewed, UniProtKB/Swiss-Prot P75389 (NAOX_MYCPN)

Last modified November 25, 2008. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Probable NADH oxidase
      Short name=NOXase
    EC=1.6.99.3
Gene names
Name: nox
Ordered Locus Names: MPN_394
ORF Names: MP444
OrganismMycoplasma pneumoniae [Complete proteome] [HAMAP]
Taxonomic identifier2104 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

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Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the four-electron reduction of molecular oxygen to water By similarity.

Catalytic activity

NADH + acceptor = NAD(+) + reduced acceptor.

Cofactor

Binds 1 FAD per subunit By similarity.

Sequence similarities

Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.

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Ontologies

Keywords

   DomainRedox-active center
   LigandFAD
Flavoprotein
NAD
   Molecular functionOxidoreductase
   PTMOxidation
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular functionFAD binding

Inferred from electronic annotation. Source: InterPro

NADH dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479Probable NADH oxidase
PRO_0000184703

Regions

Nucleotide binding8 – 125FAD By similarity
Nucleotide binding111 – 1144FAD By similarity
Nucleotide binding170 – 18516NAD By similarity
Nucleotide binding295 – 30511FAD By similarity

Sites

Active site111Proton acceptor By similarity
Active site431Redox-active
Binding site431FAD By similarity
Binding site1971NAD By similarity
Binding site2641NAD; via amide nitrogen By similarity
Binding site3231FAD; via amide nitrogen By similarity

Amino acid modifications

Modified residue431Cysteine sulfenic acid (-SOH) By similarity

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Sequences

Sequence LengthMass (Da)Tools
P75389-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 66B86EA3BA8E53F1

FASTA47952,875
        10         20         30         40         50         60 
MKKVIVIGVN HAGTSFIRTL LSKSKDFQVN AYDRNTNISF LGCGIALAVS GVVKNTEDLF 

        70         80         90        100        110        120 
YSTPEELKAM GANVFMAHDV VGLDLDKKQV IVKDLATGKE TVDHYDQLVV ASGAWPICMN 

       130        140        150        160        170        180 
VENEVTHTQL QFNHTDKYCG NIKNLISCKL YQHALTLIDS FRHDKSIKSV AIVGSGYIGL 

       190        200        210        220        230        240 
ELAEAAWQCG KQVTVIDMLD KPAGNNFDEE FTNELEKAMK KAGINLMMGS AVKGFIVDAD 

       250        260        270        280        290        300 
KNVVKGVETD KGRVDADLVI QSIGFRPNTQ FVPKDRQFEF NRNGSIKVNE YLQALNHENV 

       310        320        330        340        350        360 
YVIGGAAAIY DAASEQYENI DLATNAVKSG LVAAMHMIGS KAVKLESIVG TNALHVFGLN 

       370        380        390        400        410        420 
LAATGLTEKR AKMNGFDVGV SIVDDNDRPE FMGTFDKVRF KLIYDKKTLR LLGAQLLSWN 

       430        440        450        460        470 
TNHSEIIFYI ALAVQKKMLI SELGLVDVYF LPHYNKPFNF VLAAVLQALG FSYYTPKNK

« Hide

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References

[1]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.

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Cross-references

Sequence databases

U00089 Genomic DNA. Translation: AAB96092.1.
PIRS73770.
RefSeqNP_110082.1.

3D structure databases

HSSPHSSP built from PDB template 1NHP based on UniProtKB P37062.
ModBaseSearch...

Genome annotation databases

GeneID877135.
GenomeReviewsGene locus MPN_394 in contig U00089_GR.
KEGGmpn:MPN394.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP75389.

Enzyme and pathway databases

BioCycMPNE272634:MPN394-MON.

Family and domain databases

InterProIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR001327. Pyr_OxRdtase_NAD_bd.
[Graphical view]
Gene3DG3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
ProDomPD000139. FAD_pyr_redox. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

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Entry information

Entry nameNAOX_MYCPN
AccessionPrimary (citable) accession number: P75389
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 25, 2008
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents