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P75389

- NAOX_MYCPN

UniProt

P75389 - NAOX_MYCPN

Protein

Probable NADH oxidase

Gene

nox

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the four-electron reduction of molecular oxygen to water.By similarity

    Catalytic activityi

    NADH + acceptor = NAD+ + reduced acceptor.

    Cofactori

    Binds 1 FAD per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei11 – 111Proton acceptorBy similarity
    Active sitei43 – 431Redox-active
    Binding sitei43 – 431FADBy similarity
    Binding sitei197 – 1971NADBy similarity
    Binding sitei264 – 2641NAD; via amide nitrogenBy similarity
    Binding sitei323 – 3231FAD; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 125FADBy similarity
    Nucleotide bindingi111 – 1144FADBy similarity
    Nucleotide bindingi170 – 18516NADBy similarityAdd
    BLAST
    Nucleotide bindingi295 – 30511FADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. NADH dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-417-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable NADH oxidase (EC:1.6.99.3)
    Short name:
    NOXase
    Gene namesi
    Name:nox
    Ordered Locus Names:MPN_394
    ORF Names:MP444
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479Probable NADH oxidasePRO_0000184703Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei43 – 431Cysteine sulfenic acid (-SOH)By similarity

    Keywords - PTMi

    Oxidation

    Proteomic databases

    PaxDbiP75389.

    Interactioni

    Protein-protein interaction databases

    IntActiP75389. 2 interactions.
    STRINGi272634.MPN394.

    Structurei

    3D structure databases

    ProteinModelPortaliP75389.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG0446.
    KOiK03885.
    OMAiEQYENID.
    OrthoDBiEOG6QVRCJ.

    Family and domain databases

    Gene3Di3.30.390.30. 1 hit.
    InterProiIPR016156. FAD/NAD-linked_Rdtase_dimer.
    IPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    [Graphical view]
    PfamiPF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    PF02852. Pyr_redox_dim. 1 hit.
    [Graphical view]
    PRINTSiPR00368. FADPNR.
    SUPFAMiSSF55424. SSF55424. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P75389-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKVIVIGVN HAGTSFIRTL LSKSKDFQVN AYDRNTNISF LGCGIALAVS    50
    GVVKNTEDLF YSTPEELKAM GANVFMAHDV VGLDLDKKQV IVKDLATGKE 100
    TVDHYDQLVV ASGAWPICMN VENEVTHTQL QFNHTDKYCG NIKNLISCKL 150
    YQHALTLIDS FRHDKSIKSV AIVGSGYIGL ELAEAAWQCG KQVTVIDMLD 200
    KPAGNNFDEE FTNELEKAMK KAGINLMMGS AVKGFIVDAD KNVVKGVETD 250
    KGRVDADLVI QSIGFRPNTQ FVPKDRQFEF NRNGSIKVNE YLQALNHENV 300
    YVIGGAAAIY DAASEQYENI DLATNAVKSG LVAAMHMIGS KAVKLESIVG 350
    TNALHVFGLN LAATGLTEKR AKMNGFDVGV SIVDDNDRPE FMGTFDKVRF 400
    KLIYDKKTLR LLGAQLLSWN TNHSEIIFYI ALAVQKKMLI SELGLVDVYF 450
    LPHYNKPFNF VLAAVLQALG FSYYTPKNK 479
    Length:479
    Mass (Da):52,875
    Last modified:February 1, 1997 - v1
    Checksum:i66B86EA3BA8E53F1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96092.1.
    PIRiS73770.
    RefSeqiNP_110082.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB96092; AAB96092; MPN_394.
    GeneIDi877135.
    KEGGimpn:MPN394.
    PATRICi20022164. VBIMycPne110_0425.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96092.1 .
    PIRi S73770.
    RefSeqi NP_110082.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75389.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P75389. 2 interactions.
    STRINGi 272634.MPN394.

    Proteomic databases

    PaxDbi P75389.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB96092 ; AAB96092 ; MPN_394 .
    GeneIDi 877135.
    KEGGi mpn:MPN394.
    PATRICi 20022164. VBIMycPne110_0425.

    Phylogenomic databases

    eggNOGi COG0446.
    KOi K03885.
    OMAi EQYENID.
    OrthoDBi EOG6QVRCJ.

    Enzyme and pathway databases

    BioCyci MPNE272634:GJ6Z-417-MONOMER.

    Family and domain databases

    Gene3Di 3.30.390.30. 1 hit.
    InterProi IPR016156. FAD/NAD-linked_Rdtase_dimer.
    IPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    [Graphical view ]
    Pfami PF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    PF02852. Pyr_redox_dim. 1 hit.
    [Graphical view ]
    PRINTSi PR00368. FADPNR.
    SUPFAMi SSF55424. SSF55424. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiNAOX_MYCPN
    AccessioniPrimary (citable) accession number: P75389
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3