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Protein

Probable NADH oxidase

Gene

nox

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the four-electron reduction of molecular oxygen to water.By similarity

Catalytic activityi

NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11Proton acceptorBy similarity1
Active sitei43Redox-active1
Binding sitei43FADBy similarity1
Binding sitei197NADBy similarity1
Binding sitei264NAD; via amide nitrogenBy similarity1
Binding sitei323FAD; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 12FADBy similarity5
Nucleotide bindingi111 – 114FADBy similarity4
Nucleotide bindingi170 – 185NADBy similarityAdd BLAST16
Nucleotide bindingi295 – 305FADBy similarityAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciMPNE272634:G1GJ3-626-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable NADH oxidase (EC:1.6.99.3)
Short name:
NOXase
Gene namesi
Name:nox
Ordered Locus Names:MPN_394
ORF Names:MP444
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000808 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001847031 – 479Probable NADH oxidaseAdd BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43Cysteine sulfenic acid (-SOH)By similarity1

Keywords - PTMi

Oxidation

Interactioni

Protein-protein interaction databases

IntActiP75389, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliP75389
SMRiP75389
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

OMAiYSPCAIP

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 5 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit

Sequencei

Sequence statusi: Complete.

P75389-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVIVIGVN HAGTSFIRTL LSKSKDFQVN AYDRNTNISF LGCGIALAVS
60 70 80 90 100
GVVKNTEDLF YSTPEELKAM GANVFMAHDV VGLDLDKKQV IVKDLATGKE
110 120 130 140 150
TVDHYDQLVV ASGAWPICMN VENEVTHTQL QFNHTDKYCG NIKNLISCKL
160 170 180 190 200
YQHALTLIDS FRHDKSIKSV AIVGSGYIGL ELAEAAWQCG KQVTVIDMLD
210 220 230 240 250
KPAGNNFDEE FTNELEKAMK KAGINLMMGS AVKGFIVDAD KNVVKGVETD
260 270 280 290 300
KGRVDADLVI QSIGFRPNTQ FVPKDRQFEF NRNGSIKVNE YLQALNHENV
310 320 330 340 350
YVIGGAAAIY DAASEQYENI DLATNAVKSG LVAAMHMIGS KAVKLESIVG
360 370 380 390 400
TNALHVFGLN LAATGLTEKR AKMNGFDVGV SIVDDNDRPE FMGTFDKVRF
410 420 430 440 450
KLIYDKKTLR LLGAQLLSWN TNHSEIIFYI ALAVQKKMLI SELGLVDVYF
460 470
LPHYNKPFNF VLAAVLQALG FSYYTPKNK
Length:479
Mass (Da):52,875
Last modified:February 1, 1997 - v1
Checksum:i66B86EA3BA8E53F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA Translation: AAB96092.1
PIRiS73770
RefSeqiNP_110082.1, NC_000912.1
WP_010874750.1, NC_000912.1

Genome annotation databases

EnsemblBacteriaiAAB96092; AAB96092; MPN_394
GeneIDi877135
KEGGimpn:MPN394
PATRICifig|272634.6.peg.425

Similar proteinsi

Entry informationi

Entry nameiNAOX_MYCPN
AccessioniPrimary (citable) accession number: P75389
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health