SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P75386

- SPOT_MYCPN

UniProt

P75386 - SPOT_MYCPN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase

Gene
spoT, MPN_397, MP441
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp By similarity.

Catalytic activityi

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactori

Manganese By similarity.

Pathwayi

GO - Molecular functioni

  1. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: InterPro
  3. phosphoric diester hydrolase activity Source: InterPro

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-420-MONOMER.
UniPathwayiUPA00908; UER00886.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC:3.1.7.2)
Alternative name(s):
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name:
(ppGpp)ase
Gene namesi
Name:spoT
Ordered Locus Names:MPN_397
ORF Names:MP441
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 733733Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolasePRO_0000166573Add
BLAST

Proteomic databases

PaxDbiP75386.

Interactioni

Protein-protein interaction databases

IntActiP75386. 4 interactions.
STRINGi272634.MPN397.

Structurei

3D structure databases

ProteinModelPortaliP75386.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 167106HDAdd
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.
Contains 1 HD domain.

Phylogenomic databases

eggNOGiCOG0317.
OMAiNIMRLYQ.
OrthoDBiEOG6SV551.

Family and domain databases

InterProiIPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
[Graphical view]
PfamiPF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.

Sequencei

Sequence statusi: Complete.

P75386-1 [UniParc]FASTAAdd to Basket

« Hide

MFYNWLKLYK FSKMATLVEI ERDFLQKTAQ KFAPEVVALI TKALDYSKKW    50
HGEQKRLSGE PFFIHPLRTA LRLVEWNMDS NTVCAGLLHD IIEDTQVTEA 100
DLTAIFGKEI TDLVVKVTKI TSESKKQRQL NRKKEDLNLK SLVNIAMSSQ 150
QEVNALVLKL ADRLDNISSI EFLAVEKQKI IAKETLELYA KIAGRIGMYP 200
VKTQLADLSF KVLDPKNFNN TLSKINQQKV FYDNEWGNFK KQLEEMLEQN 250
QIEYRLESRI KGIYSTYQKL TFHEQNIAKI HDLFAIRLIV KSELDCYHLL 300
GLIHLNFTVL MKHFKDYIAS PKQNFYQSIH TTVRLKGLNV EIQIRTQRMD 350
HVSKYGFASH WIYKEKKEGL LASALQVNYL NSKQMHSRDF FKRIFGTDII 400
KVNVSSDNEP NIVKKLNVES NSKLLDIAYE LYPKQFNKLE KIKLDGVEVM 450
SFDVTAENEM VIEFCFGKTN NLKRRWLRYM NNHVFRERVK KDLNKLKKAV 500
KYSELPLYEK ALEELHLKLA DETQIKQRLN ALGIKKLTEF LELIEYPHFP 550
KNEHLYFLAS NNQKWRELIK PIKFALSQAV FQNSYFEQIE GIYITKIVIE 600
TCCTKIPDMP EQVIGILMKN ILRVHLHDCR ELANQKQPKI IPLYWNAHQL 650
KMRPRKFRCQ INIRGVWSET TVNKIVQTII EGDSYLERII PKIDKQKDEF 700
ELNITMFIDN YHQLITIMEQ ITTKNISYVW KYL 733
Length:733
Mass (Da):86,404
Last modified:February 1, 1997 - v1
Checksum:i8F45E41A34BB3940
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB96089.1.
PIRiS73767.
RefSeqiNP_110085.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96089; AAB96089; MPN_397.
GeneIDi877121.
KEGGimpn:MPN397.
PATRICi20022170. VBIMycPne110_0428.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB96089.1 .
PIRi S73767.
RefSeqi NP_110085.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75386.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P75386. 4 interactions.
STRINGi 272634.MPN397.

Proteomic databases

PaxDbi P75386.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB96089 ; AAB96089 ; MPN_397 .
GeneIDi 877121.
KEGGi mpn:MPN397.
PATRICi 20022170. VBIMycPne110_0428.

Phylogenomic databases

eggNOGi COG0317.
OMAi NIMRLYQ.
OrthoDBi EOG6SV551.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00886 .
BioCyci MPNE272634:GJ6Z-420-MONOMER.

Family and domain databases

InterProi IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
[Graphical view ]
Pfami PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiSPOT_MYCPN
AccessioniPrimary (citable) accession number: P75386
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi