Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P75386

- SPOT_MYCPN

UniProt

P75386 - SPOT_MYCPN

Protein

Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase

Gene

spoT

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp By similarity.By similarity

    Catalytic activityi

    Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

    Cofactori

    Manganese.By similarity

    Pathwayi

    GO - Molecular functioni

    1. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: InterPro
    3. phosphoric diester hydrolase activity Source: InterPro

    GO - Biological processi

    1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Manganese

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-420-MONOMER.
    UniPathwayiUPA00908; UER00886.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC:3.1.7.2)
    Alternative name(s):
    Penta-phosphate guanosine-3'-pyrophosphohydrolase
    Short name:
    (ppGpp)ase
    Gene namesi
    Name:spoT
    Ordered Locus Names:MPN_397
    ORF Names:MP441
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 733733Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolasePRO_0000166573Add
    BLAST

    Proteomic databases

    PaxDbiP75386.

    Interactioni

    Protein-protein interaction databases

    IntActiP75386. 4 interactions.
    STRINGi272634.MPN397.

    Structurei

    3D structure databases

    ProteinModelPortaliP75386.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 167106HDAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RelA/SpoT family.Curated
    Contains 1 HD domain.Curated

    Phylogenomic databases

    eggNOGiCOG0317.
    OMAiNIMRLYQ.
    OrthoDBiEOG6SV551.

    Family and domain databases

    InterProiIPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    [Graphical view]
    PfamiPF01966. HD. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    [Graphical view]
    SMARTiSM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00691. spoT_relA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P75386-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFYNWLKLYK FSKMATLVEI ERDFLQKTAQ KFAPEVVALI TKALDYSKKW    50
    HGEQKRLSGE PFFIHPLRTA LRLVEWNMDS NTVCAGLLHD IIEDTQVTEA 100
    DLTAIFGKEI TDLVVKVTKI TSESKKQRQL NRKKEDLNLK SLVNIAMSSQ 150
    QEVNALVLKL ADRLDNISSI EFLAVEKQKI IAKETLELYA KIAGRIGMYP 200
    VKTQLADLSF KVLDPKNFNN TLSKINQQKV FYDNEWGNFK KQLEEMLEQN 250
    QIEYRLESRI KGIYSTYQKL TFHEQNIAKI HDLFAIRLIV KSELDCYHLL 300
    GLIHLNFTVL MKHFKDYIAS PKQNFYQSIH TTVRLKGLNV EIQIRTQRMD 350
    HVSKYGFASH WIYKEKKEGL LASALQVNYL NSKQMHSRDF FKRIFGTDII 400
    KVNVSSDNEP NIVKKLNVES NSKLLDIAYE LYPKQFNKLE KIKLDGVEVM 450
    SFDVTAENEM VIEFCFGKTN NLKRRWLRYM NNHVFRERVK KDLNKLKKAV 500
    KYSELPLYEK ALEELHLKLA DETQIKQRLN ALGIKKLTEF LELIEYPHFP 550
    KNEHLYFLAS NNQKWRELIK PIKFALSQAV FQNSYFEQIE GIYITKIVIE 600
    TCCTKIPDMP EQVIGILMKN ILRVHLHDCR ELANQKQPKI IPLYWNAHQL 650
    KMRPRKFRCQ INIRGVWSET TVNKIVQTII EGDSYLERII PKIDKQKDEF 700
    ELNITMFIDN YHQLITIMEQ ITTKNISYVW KYL 733
    Length:733
    Mass (Da):86,404
    Last modified:February 1, 1997 - v1
    Checksum:i8F45E41A34BB3940
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96089.1.
    PIRiS73767.
    RefSeqiNP_110085.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB96089; AAB96089; MPN_397.
    GeneIDi877121.
    KEGGimpn:MPN397.
    PATRICi20022170. VBIMycPne110_0428.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96089.1 .
    PIRi S73767.
    RefSeqi NP_110085.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75386.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P75386. 4 interactions.
    STRINGi 272634.MPN397.

    Proteomic databases

    PaxDbi P75386.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB96089 ; AAB96089 ; MPN_397 .
    GeneIDi 877121.
    KEGGi mpn:MPN397.
    PATRICi 20022170. VBIMycPne110_0428.

    Phylogenomic databases

    eggNOGi COG0317.
    OMAi NIMRLYQ.
    OrthoDBi EOG6SV551.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00886 .
    BioCyci MPNE272634:GJ6Z-420-MONOMER.

    Family and domain databases

    InterProi IPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    [Graphical view ]
    Pfami PF01966. HD. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    [Graphical view ]
    SMARTi SM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiSPOT_MYCPN
    AccessioniPrimary (citable) accession number: P75386
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3