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P75382

- SYP_MYCPN

UniProt

P75382 - SYP_MYCPN

Protein

Proline--tRNA ligase

Gene

proS

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).UniRule annotation

    Catalytic activityi

    ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. proline-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. prolyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-430-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proline--tRNA ligaseUniRule annotation (EC:6.1.1.15UniRule annotation)
    Alternative name(s):
    Prolyl-tRNA synthetaseUniRule annotation
    Short name:
    ProRSUniRule annotation
    Gene namesi
    Name:proSUniRule annotation
    Ordered Locus Names:MPN_402
    ORF Names:MP436
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483Proline--tRNA ligasePRO_0000139335Add
    BLAST

    Proteomic databases

    PaxDbiP75382.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    IntActiP75382. 1 interaction.
    STRINGi272634.MPN402.

    Structurei

    3D structure databases

    ProteinModelPortaliP75382.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.UniRule annotation

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0442.
    KOiK01881.
    OMAiYTMEALM.
    OrthoDBiEOG6G7R2R.

    Family and domain databases

    Gene3Di3.30.110.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPiMF_01571. Pro_tRNA_synth_type3.
    InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR002316. Pro-tRNA-ligase_IIa.
    IPR004499. Pro-tRNA-ligase_IIa_arc-type.
    IPR016061. Pro-tRNA_ligase_II_C.
    IPR017449. Pro-tRNA_synth_II.
    [Graphical view]
    PANTHERiPTHR11451:SF6. PTHR11451:SF6. 1 hit.
    PfamiPF03129. HGTP_anticodon. 1 hit.
    PF09180. ProRS-C_1. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    [Graphical view]
    PRINTSiPR01046. TRNASYNTHPRO.
    SUPFAMiSSF52954. SSF52954. 1 hit.
    SSF64586. SSF64586. 1 hit.
    TIGRFAMsiTIGR00408. proS_fam_I. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P75382-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANKDQNLTL WYDQLLSKAQ LVSYGDVKGT NCFLPNSWNL WLQIQRLYNN    50
    ATALIKLKDK VILKQFIPIE PLPYTVEQVQ LPTLSFYSEY QKEKRHVEGF 100
    NPELFLIEQI GTKKLHDPLV LRPTSEIAFC NLWKKQSFSY QNLPVIYNQW 150
    TCVFRAEKNT RPFLRNSEFY WQETHGLFSD GVNSESAAIA FWKLYQDIIV 200
    NQLCIPAFVG LKSPNERFAG AQNTWTVESI MPDGQALQCA TSHDLGQTFT 250
    KPFGLTFQNQ ANQQAIPYSF SCGISTRILG ALLLTHSDDF GLVLPWKVAP 300
    IQVKLYLFDK KGDTKTVELA QKVQTLLEQL AIRFQFIKVE NQLGKQLGQG 350
    EVNGIPFQLI VDNPQTVNIF NRLTRVKTAY SFEQLASRFV ELVQQYHQAM 400
    YDKAKAVVQQ KVVQATTLKQ IEQAFNDKKA VLCAVRLTDT LEQQLKERYQ 450
    VTVRCCLEQL QKPQICPFSG ESAQDYVLIA RAY 483
    Length:483
    Mass (Da):55,455
    Last modified:February 1, 1997 - v1
    Checksum:iD5F4205B325951A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96084.1.
    PIRiS73762.
    RefSeqiNP_110090.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB96084; AAB96084; MPN_402.
    GeneIDi877119.
    KEGGimpn:MPN402.
    PATRICi20022194. VBIMycPne110_0435.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96084.1 .
    PIRi S73762.
    RefSeqi NP_110090.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75382.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P75382. 1 interaction.
    STRINGi 272634.MPN402.

    Proteomic databases

    PaxDbi P75382.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB96084 ; AAB96084 ; MPN_402 .
    GeneIDi 877119.
    KEGGi mpn:MPN402.
    PATRICi 20022194. VBIMycPne110_0435.

    Phylogenomic databases

    eggNOGi COG0442.
    KOi K01881.
    OMAi YTMEALM.
    OrthoDBi EOG6G7R2R.

    Enzyme and pathway databases

    BioCyci MPNE272634:GJ6Z-430-MONOMER.

    Family and domain databases

    Gene3Di 3.30.110.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPi MF_01571. Pro_tRNA_synth_type3.
    InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR002316. Pro-tRNA-ligase_IIa.
    IPR004499. Pro-tRNA-ligase_IIa_arc-type.
    IPR016061. Pro-tRNA_ligase_II_C.
    IPR017449. Pro-tRNA_synth_II.
    [Graphical view ]
    PANTHERi PTHR11451:SF6. PTHR11451:SF6. 1 hit.
    Pfami PF03129. HGTP_anticodon. 1 hit.
    PF09180. ProRS-C_1. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    [Graphical view ]
    PRINTSi PR01046. TRNASYNTHPRO.
    SUPFAMi SSF52954. SSF52954. 1 hit.
    SSF64586. SSF64586. 1 hit.
    TIGRFAMsi TIGR00408. proS_fam_I. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiSYP_MYCPN
    AccessioniPrimary (citable) accession number: P75382
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3