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Protein

Proline--tRNA ligase

Gene

proS

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).UniRule annotation

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPNE272634:G1GJ3-645-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Proline--tRNA ligaseUniRule annotation (EC:6.1.1.15UniRule annotation)
Alternative name(s):
Prolyl-tRNA synthetaseUniRule annotation
Short name:
ProRSUniRule annotation
Gene namesi
Name:proSUniRule annotation
Ordered Locus Names:MPN_402
ORF Names:MP436
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000808 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001393351 – 483Proline--tRNA ligaseAdd BLAST483

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiP75382, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP75382
SMRiP75382
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.UniRule annotation

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.UniRule annotation

Phylogenomic databases

KOiK01881
OMAiEVYWVTH

Family and domain databases

Gene3Di3.30.110.30, 1 hit
3.40.50.800, 1 hit
HAMAPiMF_01571 Pro_tRNA_synth_type3, 1 hit
InterProiView protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR002316 Pro-tRNA-ligase_IIa
IPR004499 Pro-tRNA-ligase_IIa_arc-type
IPR016061 Pro-tRNA_ligase_II_C
IPR017449 Pro-tRNA_synth_II
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PF09180 ProRS-C_1, 1 hit
PF00587 tRNA-synt_2b, 1 hit
PRINTSiPR01046 TRNASYNTHPRO
SMARTiView protein in SMART
SM00946 ProRS-C_1, 1 hit
SUPFAMiSSF64586 SSF64586, 1 hit
TIGRFAMsiTIGR00408 proS_fam_I, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

P75382-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKDQNLTL WYDQLLSKAQ LVSYGDVKGT NCFLPNSWNL WLQIQRLYNN
60 70 80 90 100
ATALIKLKDK VILKQFIPIE PLPYTVEQVQ LPTLSFYSEY QKEKRHVEGF
110 120 130 140 150
NPELFLIEQI GTKKLHDPLV LRPTSEIAFC NLWKKQSFSY QNLPVIYNQW
160 170 180 190 200
TCVFRAEKNT RPFLRNSEFY WQETHGLFSD GVNSESAAIA FWKLYQDIIV
210 220 230 240 250
NQLCIPAFVG LKSPNERFAG AQNTWTVESI MPDGQALQCA TSHDLGQTFT
260 270 280 290 300
KPFGLTFQNQ ANQQAIPYSF SCGISTRILG ALLLTHSDDF GLVLPWKVAP
310 320 330 340 350
IQVKLYLFDK KGDTKTVELA QKVQTLLEQL AIRFQFIKVE NQLGKQLGQG
360 370 380 390 400
EVNGIPFQLI VDNPQTVNIF NRLTRVKTAY SFEQLASRFV ELVQQYHQAM
410 420 430 440 450
YDKAKAVVQQ KVVQATTLKQ IEQAFNDKKA VLCAVRLTDT LEQQLKERYQ
460 470 480
VTVRCCLEQL QKPQICPFSG ESAQDYVLIA RAY
Length:483
Mass (Da):55,455
Last modified:February 1, 1997 - v1
Checksum:iD5F4205B325951A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA Translation: AAB96084.1
PIRiS73762
RefSeqiNP_110090.1, NC_000912.1
WP_010874758.1, NC_000912.1

Genome annotation databases

EnsemblBacteriaiAAB96084; AAB96084; MPN_402
GeneIDi877119
KEGGimpn:MPN402
PATRICifig|272634.6.peg.435

Similar proteinsi

Entry informationi

Entry nameiSYP_MYCPN
AccessioniPrimary (citable) accession number: P75382
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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