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P75382

- SYP_MYCPN

UniProt

P75382 - SYP_MYCPN

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Protein
Proline--tRNA ligase
Gene
proS, MPN_402, MP436
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro) By similarity.UniRule annotation

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. proline-tRNA ligase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. prolyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-430-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Proline--tRNA ligase (EC:6.1.1.15)
Alternative name(s):
Prolyl-tRNA synthetase
Short name:
ProRS
Gene namesi
Name:proS
Ordered Locus Names:MPN_402
ORF Names:MP436
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Proline--tRNA ligaseUniRule annotation
PRO_0000139335Add
BLAST

Proteomic databases

PaxDbiP75382.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

IntActiP75382. 1 interaction.
STRINGi272634.MPN402.

Structurei

3D structure databases

ProteinModelPortaliP75382.

Family & Domainsi

Domaini

Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension By similarity.UniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0442.
KOiK01881.
OMAiYTMEALM.
OrthoDBiEOG6G7R2R.

Family and domain databases

Gene3Di3.30.110.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_01571. Pro_tRNA_synth_type3.
InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002316. Pro-tRNA-ligase_IIa.
IPR004499. Pro-tRNA-ligase_IIa_arc-type.
IPR016061. Pro-tRNA_ligase_II_C.
IPR017449. Pro-tRNA_synth_II.
[Graphical view]
PANTHERiPTHR11451:SF6. PTHR11451:SF6. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
PF09180. ProRS-C_1. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PRINTSiPR01046. TRNASYNTHPRO.
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF64586. SSF64586. 1 hit.
TIGRFAMsiTIGR00408. proS_fam_I. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75382-1 [UniParc]FASTAAdd to Basket

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MANKDQNLTL WYDQLLSKAQ LVSYGDVKGT NCFLPNSWNL WLQIQRLYNN    50
ATALIKLKDK VILKQFIPIE PLPYTVEQVQ LPTLSFYSEY QKEKRHVEGF 100
NPELFLIEQI GTKKLHDPLV LRPTSEIAFC NLWKKQSFSY QNLPVIYNQW 150
TCVFRAEKNT RPFLRNSEFY WQETHGLFSD GVNSESAAIA FWKLYQDIIV 200
NQLCIPAFVG LKSPNERFAG AQNTWTVESI MPDGQALQCA TSHDLGQTFT 250
KPFGLTFQNQ ANQQAIPYSF SCGISTRILG ALLLTHSDDF GLVLPWKVAP 300
IQVKLYLFDK KGDTKTVELA QKVQTLLEQL AIRFQFIKVE NQLGKQLGQG 350
EVNGIPFQLI VDNPQTVNIF NRLTRVKTAY SFEQLASRFV ELVQQYHQAM 400
YDKAKAVVQQ KVVQATTLKQ IEQAFNDKKA VLCAVRLTDT LEQQLKERYQ 450
VTVRCCLEQL QKPQICPFSG ESAQDYVLIA RAY 483
Length:483
Mass (Da):55,455
Last modified:February 1, 1997 - v1
Checksum:iD5F4205B325951A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB96084.1.
PIRiS73762.
RefSeqiNP_110090.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96084; AAB96084; MPN_402.
GeneIDi877119.
KEGGimpn:MPN402.
PATRICi20022194. VBIMycPne110_0435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB96084.1 .
PIRi S73762.
RefSeqi NP_110090.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75382.
ModBasei Search...

Protein-protein interaction databases

IntActi P75382. 1 interaction.
STRINGi 272634.MPN402.

Proteomic databases

PaxDbi P75382.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB96084 ; AAB96084 ; MPN_402 .
GeneIDi 877119.
KEGGi mpn:MPN402.
PATRICi 20022194. VBIMycPne110_0435.

Phylogenomic databases

eggNOGi COG0442.
KOi K01881.
OMAi YTMEALM.
OrthoDBi EOG6G7R2R.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-430-MONOMER.

Family and domain databases

Gene3Di 3.30.110.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPi MF_01571. Pro_tRNA_synth_type3.
InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002316. Pro-tRNA-ligase_IIa.
IPR004499. Pro-tRNA-ligase_IIa_arc-type.
IPR016061. Pro-tRNA_ligase_II_C.
IPR017449. Pro-tRNA_synth_II.
[Graphical view ]
PANTHERi PTHR11451:SF6. PTHR11451:SF6. 1 hit.
Pfami PF03129. HGTP_anticodon. 1 hit.
PF09180. ProRS-C_1. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view ]
PRINTSi PR01046. TRNASYNTHPRO.
SUPFAMi SSF52954. SSF52954. 1 hit.
SSF64586. SSF64586. 1 hit.
TIGRFAMsi TIGR00408. proS_fam_I. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiSYP_MYCPN
AccessioniPrimary (citable) accession number: P75382
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi