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P75382

- SYP_MYCPN

UniProt

P75382 - SYP_MYCPN

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Protein

Proline--tRNA ligase

Gene

proS

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).UniRule annotation

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. proline-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. prolyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-430-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Proline--tRNA ligaseUniRule annotation (EC:6.1.1.15UniRule annotation)
Alternative name(s):
Prolyl-tRNA synthetaseUniRule annotation
Short name:
ProRSUniRule annotation
Gene namesi
Name:proSUniRule annotation
Ordered Locus Names:MPN_402
ORF Names:MP436
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Proline--tRNA ligasePRO_0000139335Add
BLAST

Proteomic databases

PaxDbiP75382.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiP75382. 1 interaction.
STRINGi272634.MPN402.

Structurei

3D structure databases

ProteinModelPortaliP75382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.UniRule annotation

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0442.
KOiK01881.
OMAiYTMEALM.
OrthoDBiEOG6G7R2R.

Family and domain databases

Gene3Di3.30.110.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_01571. Pro_tRNA_synth_type3.
InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002316. Pro-tRNA-ligase_IIa.
IPR004499. Pro-tRNA-ligase_IIa_arc-type.
IPR016061. Pro-tRNA_ligase_II_C.
IPR017449. Pro-tRNA_synth_II.
[Graphical view]
PANTHERiPTHR11451:SF6. PTHR11451:SF6. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
PF09180. ProRS-C_1. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PRINTSiPR01046. TRNASYNTHPRO.
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF64586. SSF64586. 1 hit.
TIGRFAMsiTIGR00408. proS_fam_I. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75382-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANKDQNLTL WYDQLLSKAQ LVSYGDVKGT NCFLPNSWNL WLQIQRLYNN
60 70 80 90 100
ATALIKLKDK VILKQFIPIE PLPYTVEQVQ LPTLSFYSEY QKEKRHVEGF
110 120 130 140 150
NPELFLIEQI GTKKLHDPLV LRPTSEIAFC NLWKKQSFSY QNLPVIYNQW
160 170 180 190 200
TCVFRAEKNT RPFLRNSEFY WQETHGLFSD GVNSESAAIA FWKLYQDIIV
210 220 230 240 250
NQLCIPAFVG LKSPNERFAG AQNTWTVESI MPDGQALQCA TSHDLGQTFT
260 270 280 290 300
KPFGLTFQNQ ANQQAIPYSF SCGISTRILG ALLLTHSDDF GLVLPWKVAP
310 320 330 340 350
IQVKLYLFDK KGDTKTVELA QKVQTLLEQL AIRFQFIKVE NQLGKQLGQG
360 370 380 390 400
EVNGIPFQLI VDNPQTVNIF NRLTRVKTAY SFEQLASRFV ELVQQYHQAM
410 420 430 440 450
YDKAKAVVQQ KVVQATTLKQ IEQAFNDKKA VLCAVRLTDT LEQQLKERYQ
460 470 480
VTVRCCLEQL QKPQICPFSG ESAQDYVLIA RAY
Length:483
Mass (Da):55,455
Last modified:February 1, 1997 - v1
Checksum:iD5F4205B325951A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB96084.1.
PIRiS73762.
RefSeqiNP_110090.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96084; AAB96084; MPN_402.
GeneIDi877119.
KEGGimpn:MPN402.
PATRICi20022194. VBIMycPne110_0435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB96084.1 .
PIRi S73762.
RefSeqi NP_110090.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75382.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P75382. 1 interaction.
STRINGi 272634.MPN402.

Proteomic databases

PaxDbi P75382.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB96084 ; AAB96084 ; MPN_402 .
GeneIDi 877119.
KEGGi mpn:MPN402.
PATRICi 20022194. VBIMycPne110_0435.

Phylogenomic databases

eggNOGi COG0442.
KOi K01881.
OMAi YTMEALM.
OrthoDBi EOG6G7R2R.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-430-MONOMER.

Family and domain databases

Gene3Di 3.30.110.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPi MF_01571. Pro_tRNA_synth_type3.
InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002316. Pro-tRNA-ligase_IIa.
IPR004499. Pro-tRNA-ligase_IIa_arc-type.
IPR016061. Pro-tRNA_ligase_II_C.
IPR017449. Pro-tRNA_synth_II.
[Graphical view ]
PANTHERi PTHR11451:SF6. PTHR11451:SF6. 1 hit.
Pfami PF03129. HGTP_anticodon. 1 hit.
PF09180. ProRS-C_1. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view ]
PRINTSi PR01046. TRNASYNTHPRO.
SUPFAMi SSF52954. SSF52954. 1 hit.
SSF64586. SSF64586. 1 hit.
TIGRFAMsi TIGR00408. proS_fam_I. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiSYP_MYCPN
AccessioniPrimary (citable) accession number: P75382
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3