P75362 (FTSY_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Signal recognition particle receptor FtsY
Short name=SRP receptor

Gene names

Name:	ftsY
Ordered Locus Names:	MPN_425
ORF Names:	MP416

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma pneumoniae

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) By similarity. HAMAP-Rule MF_00920
Subunit structure	Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY By similarity.
Subcellular location	Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm By similarity HAMAP-Rule MF_00920.
Sequence similarities	Belongs to the GTP-binding SRP family. FtsY subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Ligand	GTP-binding Nucleotide-binding
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell intrinsic to plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular_function	GTP binding Inferred from electronic annotation. Source: HAMAP GTPase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Signal recognition particle receptor FtsY HAMAP-Rule MF_00920		PRO_0000101137
Regions
	Nucleotide binding	143 – 150	8	GTP By similarity
	Nucleotide binding	225 – 229	5	GTP By similarity
	Nucleotide binding	289 – 292	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P75362 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 8A14C4DB9E1EAE29	FASTA	348	38,776
	10 20 30 40 50 60 MSFIHKLIQK FKPKKKLVDQ VQQAVQEKSF FQANQKSYYQ GLNKSANSFA NTINKLAANY 70 80 90 100 110 120 VTVNEQFQES LFEELVLLDI GYHAATKICD AIVQELKLQR VSDPQLIQEI IVDKLIVYYI 130 140 150 160 170 180 QDKLFETDLT VEANKTNVYL FVGVNGVGKT TSLAKLADQL TKQNKRVLMV AGDTFRAGAV 190 200 210 220 230 240 AQLAEWAQRI GCDIVLPNPK EETPAVIFRG VQQGIQNEYD FVLCDTSGRL QNKTNLMNEL 250 260 270 280 290 300 KKIYQIVQKV SSAKPQETLL VLDGTTGQSG LAQAKVFNEF TELTGIILTK MDSSSKGGII 310 320 330 340 LAIKDLFNLP VKLIGFGETT ADLAAFDLEQ YVLGLTKNLS LNHEPNQT

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB96064.1.
PIR	S73742.
RefSeq	NP_110113.1. NC_000912.1.
3D structure databases
ProteinModelPortal	P75362.
ModBase	Search...
Protein-protein interaction databases
STRING	272634.MPN425.
Proteomic databases
PaxDb	P75362.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB96064; AAB96064; MPN_425.
GeneID	876833.
KEGG	mpn:MPN425.
PATRIC	20022246. VBIMycPne110_0460.
Phylogenomic databases
eggNOG	COG0552.
KO	K03110.
OMA	AVIFRGV.
ProtClustDB	PRK10416.
Enzyme and pathway databases
BioCyc	MPNE272634:GJ6Z-454-MONOMER.
Family and domain databases
HAMAP	MF_00920. FtsY.
InterPro	IPR003593. AAA+_ATPase. IPR013822. Signal_recog_particl_SRP54_hlx. IPR004390. SR_rcpt_FtsY. IPR000897. SRP54_GTPase_dom. [Graphical view]
Pfam	PF00448. SRP54. 1 hit. PF02881. SRP54_N. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM00962. SRP54. 1 hit. SM00963. SRP54_N. 1 hit. [Graphical view]
SUPFAM	SSF47364. SRP54. 1 hit.
TIGRFAMs	TIGR00064. ftsY. 1 hit.
PROSITE	PS00300. SRP54. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTSY_MYCPN

Accession

Primary (citable) accession number: P75362

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program