P75313 (AMPP_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative Xaa-Pro aminopeptidase
Short name=X-Pro aminopeptidase
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Aminopeptidase P
Short name=APP

Gene names

Name:	pepP
Ordered Locus Names:	MPN_470
ORF Names:	MP371

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma pneumoniae

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Putative Xaa-Pro aminopeptidase		PRO_0000185078
Sites
	Metal binding	213	1	Manganese 2 By similarity
	Metal binding	224	1	Manganese 1 By similarity
	Metal binding	224	1	Manganese 2 By similarity
	Metal binding	290	1	Manganese 1 By similarity
	Metal binding	319	1	Manganese 1 By similarity
	Metal binding	333	1	Manganese 1 By similarity
	Metal binding	333	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P75313 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: A5286BD9F414A132	FASTA	354	39,624
	10 20 30 40 50 60 MHNELQQKLA VLHKLLQDNK ADAILIGSDQ NRFWLTGFPS SAGWLVVHKQ RVNLFIDGRY 70 80 90 100 110 120 FEAAKTAIDP LVKVELFTTY KQVKALCEQV GVKHLLIEGD YLTFNYQNFI KELCAQYTVI 130 140 150 160 170 180 NAQEIRRQKL PSEILAIEKV VEITRKVAVK LKRFIQPGMT ELFIAQWITD QLVKAGGAKN 190 200 210 220 230 240 SFDPIVATGK NGANPHHKPS KLKVKSGDFV TCDFGTIYNG YCSDITRTFL VGKKPNNEVL 250 260 270 280 290 300 LKAYKKVDEA NMAGINAANT QLTGAEVDKV CRDIIEASEF KDYFVHSTGH GVGLDIHEMP 310 320 330 340 350 NVSTSYNKLL CENAVITIEP GIYIPSVGGI RIEDMVLVKD HKSVWLSAKI PRAF

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB96019.1.
PIR	S73697.
RefSeq	NP_110158.1. NC_000912.1.
3D structure databases
ProteinModelPortal	P75313.
ModBase	Search...
Protein-protein interaction databases
STRING	272634.MPN470.
PTM databases
PhosSite	P10111000.
Proteomic databases
PaxDb	P75313.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB96019; AAB96019; MPN_470.
GeneID	877187.
KEGG	mpn:MPN470.
PATRIC	20022362. VBIMycPne110_0508.
Phylogenomic databases
eggNOG	COG0006.
OMA	SAKPHAT.
ProtClustDB	CLSK336957.
Enzyme and pathway databases
BioCyc	MPNE272634:GJ6Z-511-MONOMER.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP_MYCPN

Accession

Primary (citable) accession number: P75313

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program