P75308 (KCY_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase
Short name=CK
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase
Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	MPN_476
ORF Names:	MP365

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129)

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00238
Subcellular location	Cytoplasm By similarity HAMAP MF_00238.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MPN_461	P75322	1	EBI-2260403,EBI-2260400

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 217	217	Cytidylate kinase HAMAP MF_00238		PRO_0000131941
Regions
	Nucleotide binding	9 – 17	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P75308 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 5FCA216DC77FDAB2	FASTA	217	24,567
	10 20 30 40 50 60 MYFQIAIDGP SSSGKSSVAK TVARQLGFEY FSTGKMYRAF AYVMQVNRLD VNLLLKVINQ 70 80 90 100 110 120 INWRFEHEKV FYNNADISEV ILNQEIAQLA SNLATNPEVR KMAVLRQQAL AKNTNIVMDG 130 140 150 160 170 180 RDIGTVVLKD AQLKYFLDAK PEIRAQRRAQ DLGIAYDSDK AFQELVAEIK HRDAVDTSRT 190 200 210 ADPLVQAPDA IYIDSSNLTF QQVVELMVQQ ARTVFKL

References

[1]	"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB96013.1.
PIR	S73691.
RefSeq	NP_110164.1. NC_000912.1.
3D structure databases
ProteinModelPortal	P75308.
ModBase	Search...
Protein-protein interaction databases
IntAct	P75308. 1 interaction.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	877402.
GenomeReviews	Gene locus MPN_476 in contig U00089_GR.
KEGG	mpn:MPN476.
PATRIC	20022376. VBIMycPne110_0515.
Phylogenomic databases
HOGENOM	HBG354377.
OMA	DIGTVIC.
PhylomeDB	P75308.
ProtClustDB	CLSK335284.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-573. MPNE272634:MPN476-MONOMER.
Family and domain databases
HAMAP	MF_00238. Cytidyl_kinase_type1. [Tree]
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. [Graphical view]
PANTHER	PTHR21299:SF2. Cytidylate_kin. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. Cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_MYCPN

Accession

Primary (citable) accession number: P75308

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program