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P75305

- AZOR_MYCPN

UniProt

P75305 - AZOR_MYCPN

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Protein

FMN-dependent NADH-azoreductase

Gene

azoR

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity.UniRule annotation

Cofactori

FMNUniRule annotationNote: Binds 1 FMN per subunit.UniRule annotation

GO - Molecular functioni

  1. electron carrier activity Source: UniProtKB-HAMAP
  2. FMN binding Source: UniProtKB-HAMAP
  3. FMN reductase activity Source: UniProtKB-HAMAP
  4. oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor Source: UniProtKB-HAMAP
  5. oxidoreductase activity, acting on other nitrogenous compounds as donors Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN, NAD

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-520-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
FMN-dependent NADH-azoreductaseUniRule annotation (EC:1.7.-.-UniRule annotation)
Alternative name(s):
Azo-dye reductaseUniRule annotation
FMN-dependent NADH-azo compound oxidoreductaseUniRule annotation
Gene namesi
Name:azoRUniRule annotation
Ordered Locus Names:MPN_479
ORF Names:MP362
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197FMN-dependent NADH-azoreductasePRO_0000166345Add
BLAST

Proteomic databases

PaxDbiP75305.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
MPN_040P750741EBI-2260147,EBI-2260151

Protein-protein interaction databases

IntActiP75305. 1 interaction.
STRINGi272634.MPN479.

Structurei

3D structure databases

ProteinModelPortaliP75305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the azoreductase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1182.
KOiK01118.
OMAiATTKNFF.
OrthoDBiEOG6QRW9T.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01216. Azoreductase_type1.
InterProiIPR003680. Flavodoxin_fold.
IPR029039. Flavoprotein-like.
IPR023048. NADH-azoreductase_FMN-depdnt.
[Graphical view]
PANTHERiPTHR10204:SF4. PTHR10204:SF4. 1 hit.
PfamiPF02525. Flavodoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.

Sequencei

Sequence statusi: Complete.

P75305-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKVIIIDAS VSPSGSYTHL LLERFLATFQ AKNKDVELST WNLNELPVGQ
60 70 80 90 100
ISYNTQNAGT FFSVENSDKY IDALKAAHGV IILAPMTNFN YPATLKNFID
110 120 130 140 150
HVFVANKTFK DKYVTKGASS GMLGNLKVVV LGSQGAPLGW YPWGDHVNSL
160 170 180 190
RGLFGFAGVA SFASVIIDGT KLLYKDKSKS EVVDMFAKQV DAIANEF
Length:197
Mass (Da):21,550
Last modified:February 1, 1997 - v1
Checksum:iB566B394F7936D31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB96010.1.
PIRiS73688.
RefSeqiNP_110167.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96010; AAB96010; MPN_479.
GeneIDi876744.
KEGGimpn:MPN479.
PATRICi20022382. VBIMycPne110_0518.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB96010.1 .
PIRi S73688.
RefSeqi NP_110167.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P75305. 1 interaction.
STRINGi 272634.MPN479.

Proteomic databases

PaxDbi P75305.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB96010 ; AAB96010 ; MPN_479 .
GeneIDi 876744.
KEGGi mpn:MPN479.
PATRICi 20022382. VBIMycPne110_0518.

Phylogenomic databases

eggNOGi COG1182.
KOi K01118.
OMAi ATTKNFF.
OrthoDBi EOG6QRW9T.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-520-MONOMER.

Family and domain databases

Gene3Di 3.40.50.360. 1 hit.
HAMAPi MF_01216. Azoreductase_type1.
InterProi IPR003680. Flavodoxin_fold.
IPR029039. Flavoprotein-like.
IPR023048. NADH-azoreductase_FMN-depdnt.
[Graphical view ]
PANTHERi PTHR10204:SF4. PTHR10204:SF4. 1 hit.
Pfami PF02525. Flavodoxin_2. 1 hit.
[Graphical view ]
SUPFAMi SSF52218. SSF52218. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiAZOR_MYCPN
AccessioniPrimary (citable) accession number: P75305
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3