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P75305

- AZOR_MYCPN

UniProt

P75305 - AZOR_MYCPN

Protein

FMN-dependent NADH-azoreductase

Gene

azoR

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity.UniRule annotation

    Cofactori

    Binds 1 FMN per subunit.UniRule annotation

    GO - Molecular functioni

    1. electron carrier activity Source: UniProtKB-HAMAP
    2. FMN binding Source: UniProtKB-HAMAP
    3. FMN reductase activity Source: UniProtKB-HAMAP
    4. oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor Source: UniProtKB-HAMAP
    5. oxidoreductase activity, acting on other nitrogenous compounds as donors Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Flavoprotein, FMN, NAD

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-520-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FMN-dependent NADH-azoreductaseUniRule annotation (EC:1.7.-.-UniRule annotation)
    Alternative name(s):
    Azo-dye reductaseUniRule annotation
    FMN-dependent NADH-azo compound oxidoreductaseUniRule annotation
    Gene namesi
    Name:azoRUniRule annotation
    Ordered Locus Names:MPN_479
    ORF Names:MP362
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 197197FMN-dependent NADH-azoreductasePRO_0000166345Add
    BLAST

    Proteomic databases

    PaxDbiP75305.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MPN_040P750741EBI-2260147,EBI-2260151

    Protein-protein interaction databases

    IntActiP75305. 1 interaction.
    STRINGi272634.MPN479.

    Structurei

    3D structure databases

    ProteinModelPortaliP75305.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the azoreductase type 1 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1182.
    KOiK01118.
    OMAiATTKNFF.
    OrthoDBiEOG6QRW9T.

    Family and domain databases

    Gene3Di3.40.50.360. 1 hit.
    HAMAPiMF_01216. Azoreductase_type1.
    InterProiIPR003680. Flavodoxin_fold.
    IPR029039. Flavoprotein-like.
    IPR023048. NADH-azoreductase_FMN-depdnt.
    [Graphical view]
    PANTHERiPTHR10204:SF4. PTHR10204:SF4. 1 hit.
    PfamiPF02525. Flavodoxin_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF52218. SSF52218. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P75305-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKVIIIDAS VSPSGSYTHL LLERFLATFQ AKNKDVELST WNLNELPVGQ    50
    ISYNTQNAGT FFSVENSDKY IDALKAAHGV IILAPMTNFN YPATLKNFID 100
    HVFVANKTFK DKYVTKGASS GMLGNLKVVV LGSQGAPLGW YPWGDHVNSL 150
    RGLFGFAGVA SFASVIIDGT KLLYKDKSKS EVVDMFAKQV DAIANEF 197
    Length:197
    Mass (Da):21,550
    Last modified:February 1, 1997 - v1
    Checksum:iB566B394F7936D31
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96010.1.
    PIRiS73688.
    RefSeqiNP_110167.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB96010; AAB96010; MPN_479.
    GeneIDi876744.
    KEGGimpn:MPN479.
    PATRICi20022382. VBIMycPne110_0518.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96010.1 .
    PIRi S73688.
    RefSeqi NP_110167.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P75305. 1 interaction.
    STRINGi 272634.MPN479.

    Proteomic databases

    PaxDbi P75305.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB96010 ; AAB96010 ; MPN_479 .
    GeneIDi 876744.
    KEGGi mpn:MPN479.
    PATRICi 20022382. VBIMycPne110_0518.

    Phylogenomic databases

    eggNOGi COG1182.
    KOi K01118.
    OMAi ATTKNFF.
    OrthoDBi EOG6QRW9T.

    Enzyme and pathway databases

    BioCyci MPNE272634:GJ6Z-520-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.360. 1 hit.
    HAMAPi MF_01216. Azoreductase_type1.
    InterProi IPR003680. Flavodoxin_fold.
    IPR029039. Flavoprotein-like.
    IPR023048. NADH-azoreductase_FMN-depdnt.
    [Graphical view ]
    PANTHERi PTHR10204:SF4. PTHR10204:SF4. 1 hit.
    Pfami PF02525. Flavodoxin_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52218. SSF52218. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiAZOR_MYCPN
    AccessioniPrimary (citable) accession number: P75305
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3