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P75256

- TRMB_MYCPN

UniProt

P75256 - TRMB_MYCPN

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, MPN_522, G12_orf210V, MP320
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361S-adenosyl-L-methionine By similarity
Binding sitei61 – 611S-adenosyl-L-methionine By similarity
Binding sitei90 – 901S-adenosyl-L-methionine By similarity
Active sitei112 – 1121 By similarity
Binding sitei112 – 1121S-adenosyl-L-methionine By similarity
Binding sitei116 – 1161Substrate By similarity
Binding sitei148 – 1481Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-563-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:MPN_522
ORF Names:G12_orf210V, MP320
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000171359Add
BLAST

Proteomic databases

PaxDbiP75256.

Interactioni

Protein-protein interaction databases

STRINGi272634.MPN522.

Structurei

3D structure databases

ProteinModelPortaliP75256.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni188 – 1914Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
KOiK03439.
OMAiDNVMTEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75256-1 [UniParc]FASTAAdd to Basket

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MRLRKVKDAL VRVQDSPYFS NPEQLSTIES ESLFVEIGCG KSWFLSQQAQ    50
QNPKCFFVGI EREPTIVLKA INKVNRLEVK PRNLLITCLD ANQLTEYLKP 100
QSISKIFINF PDPWPKKRHT LRRLTAPHFL KQFHQLLKKQ GLIEFKTDND 150
QLFEFTLEVL QKTVAHFKII EQTTDLHNSP LTSTNIMTEY EQRFVSLGVK 200
IKKLTLEKLN 210
Length:210
Mass (Da):24,542
Last modified:February 1, 1997 - v1
Checksum:i2A41D406B3C8B83C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB95968.1.
PIRiS73646.
RefSeqiNP_110210.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95968; AAB95968; MPN_522.
GeneIDi876965.
KEGGimpn:MPN522.
PATRICi20022504. VBIMycPne110_0579.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB95968.1 .
PIRi S73646.
RefSeqi NP_110210.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75256.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272634.MPN522.

Proteomic databases

PaxDbi P75256.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB95968 ; AAB95968 ; MPN_522 .
GeneIDi 876965.
KEGGi mpn:MPN522.
PATRICi 20022504. VBIMycPne110_0579.

Phylogenomic databases

eggNOGi COG0220.
KOi K03439.
OMAi DNVMTEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci MPNE272634:GJ6Z-563-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiTRMB_MYCPN
AccessioniPrimary (citable) accession number: P75256
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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