Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribonuclease 3

Gene

rnc

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591MagnesiumUniRule annotation
Active sitei63 – 631UniRule annotation
Metal bindingi127 – 1271MagnesiumUniRule annotation
Active sitei130 – 1301UniRule annotation
Metal bindingi130 – 1301MagnesiumUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonuclease III activity Source: UniProtKB-HAMAP
  3. RNA binding Source: InterPro

GO - Biological processi

  1. mRNA processing Source: UniProtKB-HAMAP
  2. rRNA catabolic process Source: InterPro
  3. rRNA processing Source: UniProtKB-HAMAP
  4. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

mRNA processing, rRNA processing, tRNA processing

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-590-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:MPN_545
ORF Names:MP297
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Ribonuclease 3PRO_0000180411Add
BLAST

Proteomic databases

PaxDbiP75233.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272634.MPN545.

Structurei

3D structure databases

ProteinModelPortaliP75233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 141124RNase IIIUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RNase III domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0571.
KOiK03685.
OMAiVLEHNAM.
OrthoDBiEOG6T1WVS.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERiPTHR11207. PTHR11207. 1 hit.
PfamiPF00636. Ribonuclease_3. 1 hit.
[Graphical view]
SMARTiSM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiPS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKKDKTQK PKVIDEKFVA FFKSLNIEPQ NWQFYEDAFV HSSYVNENED
60 70 80 90 100
ARASYDRLEF LGDALIDFIV AKKLFELYPN YNEGMLTRTK IEIVKGENLN
110 120 130 140 150
RIGKELNFGN FIKLGKGMPY TETLFGDVLE ALVAAIYEDL GIEKANQFVE
160 170 180 190 200
EHIFKKTYSE ILKYNFFSLF QEQKLPEPRV RVSLTSNNLV LSIIELNGDI
210 220 230 240 250
IWSQAVPNSK HYDDKSVLEH NAMSAFTQFL KSGKGINFFS DIKNKLDSQK
260 270 280
PMRALTVRPK KINWKARKPK LKALKNKVKA DS
Length:282
Mass (Da):32,653
Last modified:February 1, 1997 - v1
Checksum:i47C2BC66F7450D8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95945.1.
PIRiS73623.
RefSeqiNP_110234.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95945; AAB95945; MPN_545.
GeneIDi876735.
KEGGimpn:MPN545.
PATRICi20022567. VBIMycPne110_0607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95945.1.
PIRiS73623.
RefSeqiNP_110234.1. NC_000912.1.

3D structure databases

ProteinModelPortaliP75233.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272634.MPN545.

Proteomic databases

PaxDbiP75233.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB95945; AAB95945; MPN_545.
GeneIDi876735.
KEGGimpn:MPN545.
PATRICi20022567. VBIMycPne110_0607.

Phylogenomic databases

eggNOGiCOG0571.
KOiK03685.
OMAiVLEHNAM.
OrthoDBiEOG6T1WVS.

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-590-MONOMER.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERiPTHR11207. PTHR11207. 1 hit.
PfamiPF00636. Ribonuclease_3. 1 hit.
[Graphical view]
SMARTiSM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiPS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiRNC_MYCPN
AccessioniPrimary (citable) accession number: P75233
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.