SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P75233

- RNC_MYCPN

UniProt

P75233 - RNC_MYCPN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Ribonuclease 3
Gene
rnc, MPN_545, MP297
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+ By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Magnesium By similarity
Active sitei63 – 631 Reviewed prediction
Metal bindingi127 – 1271Magnesium By similarity
Active sitei130 – 1301 By similarity
Metal bindingi130 – 1301Magnesium By similarity

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
  3. ribonuclease III activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA processing Source: UniProtKB-HAMAP
  2. rRNA catabolic process Source: InterPro
  3. rRNA processing Source: UniProtKB-HAMAP
  4. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

mRNA processing, rRNA processing, tRNA processing

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-590-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3 (EC:3.1.26.3)
Alternative name(s):
Ribonuclease III
Short name:
RNase III
Gene namesi
Name:rnc
Ordered Locus Names:MPN_545
ORF Names:MP297
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Ribonuclease 3UniRule annotation
PRO_0000180411Add
BLAST

Proteomic databases

PaxDbiP75233.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272634.MPN545.

Structurei

3D structure databases

ProteinModelPortaliP75233.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 141124RNase III
Add
BLAST

Sequence similaritiesi

Contains 1 RNase III domain.

Phylogenomic databases

eggNOGiCOG0571.
KOiK03685.
OMAiVLEHNAM.
OrthoDBiEOG6T1WVS.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERiPTHR11207. PTHR11207. 1 hit.
PfamiPF00636. Ribonuclease_3. 1 hit.
[Graphical view]
SMARTiSM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiPS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75233-1 [UniParc]FASTAAdd to Basket

« Hide

MKNKKDKTQK PKVIDEKFVA FFKSLNIEPQ NWQFYEDAFV HSSYVNENED    50
ARASYDRLEF LGDALIDFIV AKKLFELYPN YNEGMLTRTK IEIVKGENLN 100
RIGKELNFGN FIKLGKGMPY TETLFGDVLE ALVAAIYEDL GIEKANQFVE 150
EHIFKKTYSE ILKYNFFSLF QEQKLPEPRV RVSLTSNNLV LSIIELNGDI 200
IWSQAVPNSK HYDDKSVLEH NAMSAFTQFL KSGKGINFFS DIKNKLDSQK 250
PMRALTVRPK KINWKARKPK LKALKNKVKA DS 282
Length:282
Mass (Da):32,653
Last modified:February 1, 1997 - v1
Checksum:i47C2BC66F7450D8C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB95945.1.
PIRiS73623.
RefSeqiNP_110234.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95945; AAB95945; MPN_545.
GeneIDi876735.
KEGGimpn:MPN545.
PATRICi20022567. VBIMycPne110_0607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB95945.1 .
PIRi S73623.
RefSeqi NP_110234.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75233.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272634.MPN545.

Proteomic databases

PaxDbi P75233.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB95945 ; AAB95945 ; MPN_545 .
GeneIDi 876735.
KEGGi mpn:MPN545.
PATRICi 20022567. VBIMycPne110_0607.

Phylogenomic databases

eggNOGi COG0571.
KOi K03685.
OMAi VLEHNAM.
OrthoDBi EOG6T1WVS.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-590-MONOMER.

Family and domain databases

Gene3Di 1.10.1520.10. 1 hit.
HAMAPi MF_00104. RNase_III.
InterProi IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view ]
PANTHERi PTHR11207. PTHR11207. 1 hit.
Pfami PF00636. Ribonuclease_3. 1 hit.
[Graphical view ]
SMARTi SM00535. RIBOc. 1 hit.
[Graphical view ]
SUPFAMi SSF69065. SSF69065. 1 hit.
TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
PROSITEi PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiRNC_MYCPN
AccessioniPrimary (citable) accession number: P75233
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi