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P75233

- RNC_MYCPN

UniProt

P75233 - RNC_MYCPN

Protein

Ribonuclease 3

Gene

rnc

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

    Cofactori

    Mg2+.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi59 – 591MagnesiumUniRule annotation
    Active sitei63 – 631UniRule annotation
    Metal bindingi127 – 1271MagnesiumUniRule annotation
    Active sitei130 – 1301UniRule annotation
    Metal bindingi130 – 1301MagnesiumUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonuclease III activity Source: UniProtKB-HAMAP
    3. RNA binding Source: InterPro

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-HAMAP
    2. rRNA catabolic process Source: InterPro
    3. rRNA processing Source: UniProtKB-HAMAP
    4. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    mRNA processing, rRNA processing, tRNA processing

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-590-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
    Alternative name(s):
    Ribonuclease IIIUniRule annotation
    Short name:
    RNase IIIUniRule annotation
    Gene namesi
    Name:rncUniRule annotation
    Ordered Locus Names:MPN_545
    ORF Names:MP297
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282Ribonuclease 3PRO_0000180411Add
    BLAST

    Proteomic databases

    PaxDbiP75233.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272634.MPN545.

    Structurei

    3D structure databases

    ProteinModelPortaliP75233.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 141124RNase IIIUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RNase III domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0571.
    KOiK03685.
    OMAiVLEHNAM.
    OrthoDBiEOG6T1WVS.

    Family and domain databases

    Gene3Di1.10.1520.10. 1 hit.
    HAMAPiMF_00104. RNase_III.
    InterProiIPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view]
    PANTHERiPTHR11207. PTHR11207. 1 hit.
    PfamiPF00636. Ribonuclease_3. 1 hit.
    [Graphical view]
    SMARTiSM00535. RIBOc. 1 hit.
    [Graphical view]
    SUPFAMiSSF69065. SSF69065. 1 hit.
    TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
    PROSITEiPS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P75233-1 [UniParc]FASTAAdd to Basket

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    MKNKKDKTQK PKVIDEKFVA FFKSLNIEPQ NWQFYEDAFV HSSYVNENED    50
    ARASYDRLEF LGDALIDFIV AKKLFELYPN YNEGMLTRTK IEIVKGENLN 100
    RIGKELNFGN FIKLGKGMPY TETLFGDVLE ALVAAIYEDL GIEKANQFVE 150
    EHIFKKTYSE ILKYNFFSLF QEQKLPEPRV RVSLTSNNLV LSIIELNGDI 200
    IWSQAVPNSK HYDDKSVLEH NAMSAFTQFL KSGKGINFFS DIKNKLDSQK 250
    PMRALTVRPK KINWKARKPK LKALKNKVKA DS 282
    Length:282
    Mass (Da):32,653
    Last modified:February 1, 1997 - v1
    Checksum:i47C2BC66F7450D8C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95945.1.
    PIRiS73623.
    RefSeqiNP_110234.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB95945; AAB95945; MPN_545.
    GeneIDi876735.
    KEGGimpn:MPN545.
    PATRICi20022567. VBIMycPne110_0607.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95945.1 .
    PIRi S73623.
    RefSeqi NP_110234.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75233.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272634.MPN545.

    Proteomic databases

    PaxDbi P75233.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB95945 ; AAB95945 ; MPN_545 .
    GeneIDi 876735.
    KEGGi mpn:MPN545.
    PATRICi 20022567. VBIMycPne110_0607.

    Phylogenomic databases

    eggNOGi COG0571.
    KOi K03685.
    OMAi VLEHNAM.
    OrthoDBi EOG6T1WVS.

    Enzyme and pathway databases

    BioCyci MPNE272634:GJ6Z-590-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1520.10. 1 hit.
    HAMAPi MF_00104. RNase_III.
    InterProi IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view ]
    PANTHERi PTHR11207. PTHR11207. 1 hit.
    Pfami PF00636. Ribonuclease_3. 1 hit.
    [Graphical view ]
    SMARTi SM00535. RIBOc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69065. SSF69065. 1 hit.
    TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
    PROSITEi PS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiRNC_MYCPN
    AccessioniPrimary (citable) accession number: P75233
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3