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P75233

- RNC_MYCPN

UniProt

P75233 - RNC_MYCPN

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Protein

Ribonuclease 3

Gene

rnc

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591MagnesiumUniRule annotation
Active sitei63 – 631UniRule annotation
Metal bindingi127 – 1271MagnesiumUniRule annotation
Active sitei130 – 1301UniRule annotation
Metal bindingi130 – 1301MagnesiumUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonuclease III activity Source: UniProtKB-HAMAP
  3. RNA binding Source: InterPro

GO - Biological processi

  1. mRNA processing Source: UniProtKB-HAMAP
  2. rRNA catabolic process Source: InterPro
  3. rRNA processing Source: UniProtKB-HAMAP
  4. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

mRNA processing, rRNA processing, tRNA processing

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-590-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:MPN_545
ORF Names:MP297
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Ribonuclease 3PRO_0000180411Add
BLAST

Proteomic databases

PaxDbiP75233.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272634.MPN545.

Structurei

3D structure databases

ProteinModelPortaliP75233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 141124RNase IIIUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RNase III domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0571.
KOiK03685.
OMAiVLEHNAM.
OrthoDBiEOG6T1WVS.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERiPTHR11207. PTHR11207. 1 hit.
PfamiPF00636. Ribonuclease_3. 1 hit.
[Graphical view]
SMARTiSM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiPS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75233-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNKKDKTQK PKVIDEKFVA FFKSLNIEPQ NWQFYEDAFV HSSYVNENED
60 70 80 90 100
ARASYDRLEF LGDALIDFIV AKKLFELYPN YNEGMLTRTK IEIVKGENLN
110 120 130 140 150
RIGKELNFGN FIKLGKGMPY TETLFGDVLE ALVAAIYEDL GIEKANQFVE
160 170 180 190 200
EHIFKKTYSE ILKYNFFSLF QEQKLPEPRV RVSLTSNNLV LSIIELNGDI
210 220 230 240 250
IWSQAVPNSK HYDDKSVLEH NAMSAFTQFL KSGKGINFFS DIKNKLDSQK
260 270 280
PMRALTVRPK KINWKARKPK LKALKNKVKA DS
Length:282
Mass (Da):32,653
Last modified:February 1, 1997 - v1
Checksum:i47C2BC66F7450D8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95945.1.
PIRiS73623.
RefSeqiNP_110234.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95945; AAB95945; MPN_545.
GeneIDi876735.
KEGGimpn:MPN545.
PATRICi20022567. VBIMycPne110_0607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95945.1 .
PIRi S73623.
RefSeqi NP_110234.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75233.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272634.MPN545.

Proteomic databases

PaxDbi P75233.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB95945 ; AAB95945 ; MPN_545 .
GeneIDi 876735.
KEGGi mpn:MPN545.
PATRICi 20022567. VBIMycPne110_0607.

Phylogenomic databases

eggNOGi COG0571.
KOi K03685.
OMAi VLEHNAM.
OrthoDBi EOG6T1WVS.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-590-MONOMER.

Family and domain databases

Gene3Di 1.10.1520.10. 1 hit.
HAMAPi MF_00104. RNase_III.
InterProi IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view ]
PANTHERi PTHR11207. PTHR11207. 1 hit.
Pfami PF00636. Ribonuclease_3. 1 hit.
[Graphical view ]
SMARTi SM00535. RIBOc. 1 hit.
[Graphical view ]
SUPFAMi SSF69065. SSF69065. 1 hit.
TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
PROSITEi PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiRNC_MYCPN
AccessioniPrimary (citable) accession number: P75233
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3