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P75222

- SYR_MYCPN

UniProt

P75222 - SYR_MYCPN

Protein

Arginine--tRNA ligase

Gene

argS

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

    GO - Molecular functioni

    1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-601-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine--tRNA ligase (EC:6.1.1.19)
    Alternative name(s):
    Arginyl-tRNA synthetase
    Short name:
    ArgRS
    Gene namesi
    Name:argS
    Ordered Locus Names:MPN_556
    ORF Names:MP286
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 537537Arginine--tRNA ligasePRO_0000151578Add
    BLAST

    Proteomic databases

    PaxDbiP75222.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    IntActiP75222. 2 interactions.
    STRINGi272634.MPN556.

    Structurei

    3D structure databases

    ProteinModelPortaliP75222.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi113 – 12311"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0018.
    KOiK01887.
    OMAiQQEVFRS.
    OrthoDBiEOG6JB13C.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00123. Arg_tRNA_synth.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR11956. PTHR11956. 1 hit.
    PfamiPF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view]
    PRINTSiPR01038. TRNASYNTHARG.
    SMARTiSM00836. DALR_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    TIGRFAMsiTIGR00456. argS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P75222-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFINTDLQE CLNALNLEFD EHKELVKLVK NNSFSGFAST VVFHLKGVNQ    50
    KETAQQIAAW LLKHKKAHYR RVFVANNNFI NFEISPQKYL DFLKTKPTFA 100
    PKPTKVLIEW VSANPTGELH LGHVRNAFFG HVLNNLMVFL GFQTVREYWV 150
    NDYGQQARVF GFSVYQALHL QQNIKVTPHP DGYEGELVDS IAKTITGIPL 200
    DKLSFEEFLQ QPFLDQLLAD CTAKVLEVIK QDLATIHIHF DSWKFESQVV 250
    KETDYKKLLT QFKDEAHYEK DGAIWLKTTL YGDDKDRVLV RQDNRPSYFG 300
    TDVAYHLDKA ARGFDLLYDI WGSDHEGHIK RMHCVYEGLK IHQKCQLKIT 350
    ALQLVMLYKN KEIVRLSKRA GNVITIKQML QMLSEDAARW FMLSQTNNSI 400
    IKIDLDTANL QNSSNPVYYV QYAYARMCSV LKVVDQAALA QVNDCSLLTH 450
    EKEIALLDQL VYFKSLLEKV QVSHELHLLT NYLYETATLF HSWYKACKIN 500
    DPAQYNLTQQ RLLLLQSLHH VFGQLLQILN ITAPQQM 537
    Length:537
    Mass (Da):62,121
    Last modified:February 1, 1997 - v1
    Checksum:i099B1C0DC33A39B2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95934.1.
    PIRiS73612.
    RefSeqiNP_110245.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB95934; AAB95934; MPN_556.
    GeneIDi877288.
    KEGGimpn:MPN556.
    PATRICi20022589. VBIMycPne110_0618.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95934.1 .
    PIRi S73612.
    RefSeqi NP_110245.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75222.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P75222. 2 interactions.
    STRINGi 272634.MPN556.

    Proteomic databases

    PaxDbi P75222.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB95934 ; AAB95934 ; MPN_556 .
    GeneIDi 877288.
    KEGGi mpn:MPN556.
    PATRICi 20022589. VBIMycPne110_0618.

    Phylogenomic databases

    eggNOGi COG0018.
    KOi K01887.
    OMAi QQEVFRS.
    OrthoDBi EOG6JB13C.

    Enzyme and pathway databases

    BioCyci MPNE272634:GJ6Z-601-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00123. Arg_tRNA_synth.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR11956. PTHR11956. 1 hit.
    Pfami PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view ]
    PRINTSi PR01038. TRNASYNTHARG.
    SMARTi SM00836. DALR_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    TIGRFAMsi TIGR00456. argS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiSYR_MYCPN
    AccessioniPrimary (citable) accession number: P75222
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3