Reviewed, UniProtKB/Swiss-Prot P75214 (ADH_MYCPN)

Names and origin

Protein names

Recommended name:
    Probable NADP-dependent alcohol dehydrogenase
    EC=1.1.1.2

Gene names

Name:	adh
Ordered Locus Names:	MPN_564
ORF Names:	MP278

Organism

Mycoplasma pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

2104 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An alcohol + NADP(+) = an aldehyde + NADPH.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Ligand	Metal-binding NADP Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: InterPro
Molecular function	alcohol dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Probable NADP-dependent alcohol dehydrogenase		PRO_0000160746
Sites
	Metal binding	37	1	Zinc; catalytic By similarity
	Metal binding	59	1	Zinc; catalytic By similarity
	Metal binding	60	1	Zinc; catalytic By similarity
	Metal binding	150	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	P75214-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 3153B93BFFE64D2C	FASTA	351	37,812
	10 20 30 40 50 60 MKAYAMLKIG ATGWIEKPRP VCGPNDAIIR PLAVAPCTSD VHTVWEGGIG ERHNMVLGHE 70 80 90 100 110 120 GCGVVDEVGS EVKSFKVGDR VLVAAITPEW NSVNAQAGYP MHSGGMLGGW KFSNVKDGMF 130 140 150 160 170 180 AEYFHVNDAE GNLALMPEGM DLADACMLSD MIPTGFHANE LADIQYGVAL SFFCAGPVGL 190 200 210 220 230 240 MAIAGAALKG AGRIIVVDSR PDIVEIAKAY GATDYIDFKK VSVVDEILKW TNNEGVEKVL 250 260 270 280 290 300 ISGGGSTILE TAIKVLRPGG KIGNVNYFGA GEFLTIPRVE WGVGMAHKAI HGGLMLGGRL 310 320 330 340 350 RLEKLARLIM TKKLDPSKMI THRFKGFEHI EEALFLMKDK PKDLIKSVVI F

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00089 Genomic DNA. Translation: AAB95926.1.
PIR	S73604.
RefSeq	NP_110253.1.
3D structure databases
HSSP	HSSP built from PDB template 1YKF based on UniProtKB P14941.
ModBase	Search...
Genome annotation databases
GeneID	876853.
GenomeReviews	Gene locus MPN_564 in contig U00089_GR.
KEGG	mpn:MPN564.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P75214.
Enzyme and pathway databases
BioCyc	MPNE272634:MPN564-MON.
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR013149. AlcDHase_Zn-bd. IPR002328. AlcDHase_Zn_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH_MYCPN

Accession

Primary (citable) accession number: P75214

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	November 25, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)