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P75180 (T1SH_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative type-1 restriction enzyme specificity protein MPN_615
Alternative name(s):
S.MpnORFHP
Type I restriction enzyme specificity protein MPN_615
Short name=S protein
Gene names
Ordered Locus Names:MPN_615
ORF Names:C12_orf249, MP227
OrganismMycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]
Taxonomic identifier272634 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. Subunit S dictates DNA sequences specificity By similarity.

Subunit structure

The type I restriction/modification system is composed of three polypeptides R, M and S By similarity.

Domain

Contains two DNA recognition domains, each specifying recognition of one of the two defined components of the target sequence By similarity.

Sequence similarities

Belongs to the type-I restriction system S methylase family.

Ontologies

Keywords
   Biological processRestriction system
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA restriction-modification system

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 249249Putative type-1 restriction enzyme specificity protein MPN_615
PRO_0000198052

Sequences

Sequence LengthMass (Da)Tools
P75180 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 14AC1D1350DB5855

FASTA24928,758
        10         20         30         40         50         60 
MQGILAEIEL DFPPLQIQEK IATILDTFTE LSAELRERKK QYAFYRDYLL NQENIRKIYG 

        70         80         90        100        110        120 
ANIPFETFQV KDICEIRRGR AITKAYIRNN PGENPVYSAA TTNDGELGRI KDCDFDGEYI 

       130        140        150        160        170        180 
TWTTNGYAGV VFYRNGKFNA SQDCGVLKVK NKKICTKFLS FLLKIEAPKF VHNLASRPKL 

       190        200        210        220        230        240 
SQKVMAEIEL SFPPLEIQEK IADILFAFEK LCNDLVEGIP AEIEMRKKQL DYYYHLIFSK 


IAHFSKQLA 

« Hide

References

[1]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00089 Genomic DNA. Translation: AAB95875.1.
PIRS73553.

3D structure databases

ProteinModelPortalP75180.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP75180. 2 interactions.
STRING272634.MPN615.

Protein family/group databases

REBASE6707. S.MpnORF615P.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB95875; AAB95875; MPN_615.
PATRIC20022713. VBIMycPne110_0679.

Phylogenomic databases

OMASKTTENG.
OrthoDBEOG6PKF94.
ProtClustDBCLSK335342.

Enzyme and pathway databases

BioCycMPNE272634:GJ6Z-661-MONOMER.

Family and domain databases

InterProIPR000055. Restrct_endonuc_typeI_HsdS.
[Graphical view]
PfamPF01420. Methylase_S. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameT1SH_MYCPN
AccessionPrimary (citable) accession number: P75180
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names