P75180 (T1SH_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative type-1 restriction enzyme specificity protein MPN_615

Alternative name(s):
S.MpnORFHP
Type I restriction enzyme specificity protein MPN_615
Short name=S protein

Gene names

Ordered Locus Names:	MPN_615
ORF Names:	C12_orf249, MP227

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma pneumoniae

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. Subunit S dictates DNA sequences specificity By similarity.
Subunit structure	The type I restriction/modification system is composed of three polypeptides R, M and S By similarity.
Domain	Contains two DNA recognition domains, each specifying recognition of one of the two defined components of the target sequence By similarity.
Sequence similarities	Belongs to the type-I restriction system S methylase family.

Ontologies

Keywords
Biological process	Restriction system
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA restriction-modification system Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 249	249	Putative type-1 restriction enzyme specificity protein MPN_615		PRO_0000198052

Sequences

	Sequence		Length	Mass (Da)
	P75180 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 14AC1D1350DB5855	FASTA	249	28,758
	10 20 30 40 50 60 MQGILAEIEL DFPPLQIQEK IATILDTFTE LSAELRERKK QYAFYRDYLL NQENIRKIYG 70 80 90 100 110 120 ANIPFETFQV KDICEIRRGR AITKAYIRNN PGENPVYSAA TTNDGELGRI KDCDFDGEYI 130 140 150 160 170 180 TWTTNGYAGV VFYRNGKFNA SQDCGVLKVK NKKICTKFLS FLLKIEAPKF VHNLASRPKL 190 200 210 220 230 240 SQKVMAEIEL SFPPLEIQEK IADILFAFEK LCNDLVEGIP AEIEMRKKQL DYYYHLIFSK IAHFSKQLA

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB95875.1.
PIR	S73553.
RefSeq	NP_110304.1. NC_000912.1.
3D structure databases
ProteinModelPortal	P75180.
ModBase	Search...
Protein-protein interaction databases
IntAct	P75180. 2 interactions.
STRING	272634.MPN615.
Protein family/group databases
REBASE	6707. S.MpnORF615P.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB95875; AAB95875; MPN_615.
GeneID	876975.
KEGG	mpn:MPN615.
PATRIC	20022713. VBIMycPne110_0679.
Phylogenomic databases
KO	K01154.
OMA	IPAEIEM.
ProtClustDB	CLSK335342.
Enzyme and pathway databases
BioCyc	MPNE272634:GJ6Z-661-MONOMER.
Family and domain databases
InterPro	IPR000055. Restrct_endonuc_typeI_HsdS. [Graphical view]
Pfam	PF01420. Methylase_S. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

T1SH_MYCPN

Accession

Primary (citable) accession number: P75180

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program