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P75177 (DPO3X_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA polymerase III subunit gamma/tau

EC=2.7.7.7
Gene names
Name:dnaX
Ordered Locus Names:MPN_618
ORF Names:MP224
OrganismMycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]
Taxonomic identifier272634 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length681 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Subunit structure

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.

Sequence similarities

Belongs to the DnaX/STICHEL family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 681681DNA polymerase III subunit gamma/tau
PRO_0000105499

Regions

Nucleotide binding44 – 518ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P75177 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: E3DDC6A580FFCBCC

FASTA68176,213
        10         20         30         40         50         60 
MRKVLYQKYR PTKFSDTVGQ DSIKRIIVNA ITQDQLPHGY IFAGERGTGK TTFAKIIAKA 

        70         80         90        100        110        120 
INCLNWNGDV CNQCEACQAI NSNSAIDVFE IDAASKNGIN DIRELAENVF NLPFKFKKKV 

       130        140        150        160        170        180 
YILDEAHMLT PQSWSGLLKT LEEAPDYVLF IFATTEFNKI PITILSRCQS FFFKQITNDL 

       190        200        210        220        230        240 
IQQRLAEVAA KESIKITTDA LVKLADLAQG SLRDGLSLLD QISNFSESKT ISLADVEKTF 

       250        260        270        280        290        300 
NLLDKEQKFG FIEAVLSGDL KQSFHLIDNF ESQGINFVHF LRELFALTVD LYGYVKTGQI 

       310        320        330        340        350        360 
AVVKPSDQTM AAKLRFHPKQ YALLVQAIEA NTGYGPSQLS LSDQIKAIVI HYNNAVSKEP 

       370        380        390        400        410        420 
HIPAYTPVVQ TQSPAKEHVP SKTVEEAKPQ LPAKEPVLYK VIEEPKVSSF VKDPVASKLI 

       430        440        450        460        470        480 
EQPQTIVQPE AQQEITEVEQ PTETSPAPAT DLFGLAIKPE VVRKRGRRPL SVENTDFFQP 

       490        500        510        520        530        540 
AVKKLIQPVS KPAPIKLIEP SDNNPVSIPI KLNRAVIAVS VYGHNDPKLV AHFQQLLDSF 

       550        560        570        580        590        600 
KREFTQAEKT KDSSYLKQFS DKFTASDLSK VIKVLAASPF GLVLIFEDKE IATRLWKEAL 

       610        620        630        640        650        660 
TEATAQATLL EIFQQNLFLS SFTLSEYETK VLAKVEQLTH KPQVLQLQQL EQLSSTVVKK 

       670        680 
AQKTAAQEIA DTFFKGLYEE K 

« Hide

References

[1]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00089 Genomic DNA. Translation: AAB95872.1.
PIRS73550.
RefSeqNP_110307.1. NC_000912.1.

3D structure databases

ProteinModelPortalP75177.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP75177. 5 interactions.
STRING272634.MPN618.

Proteomic databases

PaxDbP75177.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB95872; AAB95872; MPN_618.
GeneID877276.
KEGGmpn:MPN618.
PATRIC20022719. VBIMycPne110_0682.

Phylogenomic databases

eggNOGCOG2812.
KOK02343.
OMAAINCLNW.
OrthoDBEOG6WQD76.

Enzyme and pathway databases

BioCycMPNE272634:GJ6Z-664-MONOMER.

Family and domain databases

InterProIPR003593. AAA+_ATPase.
IPR012763. DNA_pol_III_sug/sutau.
IPR027417. P-loop_NTPase.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR02397. dnaX_nterm. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDPO3X_MYCPN
AccessionPrimary (citable) accession number: P75177
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: February 19, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names