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P75177

- DPO3X_MYCPN

UniProt

P75177 - DPO3X_MYCPN

Protein

DNA polymerase III subunit gamma/tau

Gene

dnaX

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi44 – 518ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
    3. nucleoside-triphosphatase activity Source: InterPro

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-664-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase III subunit gamma/tau (EC:2.7.7.7)
    Gene namesi
    Name:dnaX
    Ordered Locus Names:MPN_618
    ORF Names:MP224
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. DNA polymerase III complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 681681DNA polymerase III subunit gamma/tauPRO_0000105499Add
    BLAST

    Proteomic databases

    PaxDbiP75177.

    Interactioni

    Subunit structurei

    DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.By similarity

    Protein-protein interaction databases

    IntActiP75177. 5 interactions.
    STRINGi272634.MPN618.

    Structurei

    3D structure databases

    ProteinModelPortaliP75177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DnaX/STICHEL family.Curated

    Phylogenomic databases

    eggNOGiCOG2812.
    KOiK02343.
    OMAiAINCLNW.
    OrthoDBiEOG6WQD76.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR012763. DNA_pol_III_sug/sutau.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR02397. dnaX_nterm. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P75177-1 [UniParc]FASTAAdd to Basket

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    MRKVLYQKYR PTKFSDTVGQ DSIKRIIVNA ITQDQLPHGY IFAGERGTGK    50
    TTFAKIIAKA INCLNWNGDV CNQCEACQAI NSNSAIDVFE IDAASKNGIN 100
    DIRELAENVF NLPFKFKKKV YILDEAHMLT PQSWSGLLKT LEEAPDYVLF 150
    IFATTEFNKI PITILSRCQS FFFKQITNDL IQQRLAEVAA KESIKITTDA 200
    LVKLADLAQG SLRDGLSLLD QISNFSESKT ISLADVEKTF NLLDKEQKFG 250
    FIEAVLSGDL KQSFHLIDNF ESQGINFVHF LRELFALTVD LYGYVKTGQI 300
    AVVKPSDQTM AAKLRFHPKQ YALLVQAIEA NTGYGPSQLS LSDQIKAIVI 350
    HYNNAVSKEP HIPAYTPVVQ TQSPAKEHVP SKTVEEAKPQ LPAKEPVLYK 400
    VIEEPKVSSF VKDPVASKLI EQPQTIVQPE AQQEITEVEQ PTETSPAPAT 450
    DLFGLAIKPE VVRKRGRRPL SVENTDFFQP AVKKLIQPVS KPAPIKLIEP 500
    SDNNPVSIPI KLNRAVIAVS VYGHNDPKLV AHFQQLLDSF KREFTQAEKT 550
    KDSSYLKQFS DKFTASDLSK VIKVLAASPF GLVLIFEDKE IATRLWKEAL 600
    TEATAQATLL EIFQQNLFLS SFTLSEYETK VLAKVEQLTH KPQVLQLQQL 650
    EQLSSTVVKK AQKTAAQEIA DTFFKGLYEE K 681
    Length:681
    Mass (Da):76,213
    Last modified:February 1, 1997 - v1
    Checksum:iE3DDC6A580FFCBCC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95872.1.
    PIRiS73550.
    RefSeqiNP_110307.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB95872; AAB95872; MPN_618.
    GeneIDi877276.
    KEGGimpn:MPN618.
    PATRICi20022719. VBIMycPne110_0682.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95872.1 .
    PIRi S73550.
    RefSeqi NP_110307.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P75177. 5 interactions.
    STRINGi 272634.MPN618.

    Proteomic databases

    PaxDbi P75177.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB95872 ; AAB95872 ; MPN_618 .
    GeneIDi 877276.
    KEGGi mpn:MPN618.
    PATRICi 20022719. VBIMycPne110_0682.

    Phylogenomic databases

    eggNOGi COG2812.
    KOi K02343.
    OMAi AINCLNW.
    OrthoDBi EOG6WQD76.

    Enzyme and pathway databases

    BioCyci MPNE272634:GJ6Z-664-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR012763. DNA_pol_III_sug/sutau.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR02397. dnaX_nterm. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiDPO3X_MYCPN
    AccessioniPrimary (citable) accession number: P75177
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3