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Protein

DNA polymerase III subunit gamma/tau

Gene

dnaX

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 518ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-664-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase III subunit gamma/tau (EC:2.7.7.7)
Gene namesi
Name:dnaX
Ordered Locus Names:MPN_618
ORF Names:MP224
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. DNA polymerase III complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 681681DNA polymerase III subunit gamma/tauPRO_0000105499Add
BLAST

Proteomic databases

PaxDbiP75177.

Interactioni

Subunit structurei

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).By similarity

Protein-protein interaction databases

IntActiP75177. 5 interactions.
STRINGi272634.MPN618.

Structurei

3D structure databases

ProteinModelPortaliP75177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaX/STICHEL family.Curated

Phylogenomic databases

eggNOGiCOG2812.
KOiK02343.
OMAiAINCLNW.
OrthoDBiEOG6WQD76.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR012763. DNA_pol_III_sug/sutau.
IPR027417. P-loop_NTPase.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02397. dnaX_nterm. 1 hit.

Sequencei

Sequence statusi: Complete.

P75177-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKVLYQKYR PTKFSDTVGQ DSIKRIIVNA ITQDQLPHGY IFAGERGTGK
60 70 80 90 100
TTFAKIIAKA INCLNWNGDV CNQCEACQAI NSNSAIDVFE IDAASKNGIN
110 120 130 140 150
DIRELAENVF NLPFKFKKKV YILDEAHMLT PQSWSGLLKT LEEAPDYVLF
160 170 180 190 200
IFATTEFNKI PITILSRCQS FFFKQITNDL IQQRLAEVAA KESIKITTDA
210 220 230 240 250
LVKLADLAQG SLRDGLSLLD QISNFSESKT ISLADVEKTF NLLDKEQKFG
260 270 280 290 300
FIEAVLSGDL KQSFHLIDNF ESQGINFVHF LRELFALTVD LYGYVKTGQI
310 320 330 340 350
AVVKPSDQTM AAKLRFHPKQ YALLVQAIEA NTGYGPSQLS LSDQIKAIVI
360 370 380 390 400
HYNNAVSKEP HIPAYTPVVQ TQSPAKEHVP SKTVEEAKPQ LPAKEPVLYK
410 420 430 440 450
VIEEPKVSSF VKDPVASKLI EQPQTIVQPE AQQEITEVEQ PTETSPAPAT
460 470 480 490 500
DLFGLAIKPE VVRKRGRRPL SVENTDFFQP AVKKLIQPVS KPAPIKLIEP
510 520 530 540 550
SDNNPVSIPI KLNRAVIAVS VYGHNDPKLV AHFQQLLDSF KREFTQAEKT
560 570 580 590 600
KDSSYLKQFS DKFTASDLSK VIKVLAASPF GLVLIFEDKE IATRLWKEAL
610 620 630 640 650
TEATAQATLL EIFQQNLFLS SFTLSEYETK VLAKVEQLTH KPQVLQLQQL
660 670 680
EQLSSTVVKK AQKTAAQEIA DTFFKGLYEE K
Length:681
Mass (Da):76,213
Last modified:February 1, 1997 - v1
Checksum:iE3DDC6A580FFCBCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95872.1.
PIRiS73550.
RefSeqiNP_110307.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95872; AAB95872; MPN_618.
GeneIDi877276.
KEGGimpn:MPN618.
PATRICi20022719. VBIMycPne110_0682.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95872.1.
PIRiS73550.
RefSeqiNP_110307.1. NC_000912.1.

3D structure databases

ProteinModelPortaliP75177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP75177. 5 interactions.
STRINGi272634.MPN618.

Proteomic databases

PaxDbiP75177.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB95872; AAB95872; MPN_618.
GeneIDi877276.
KEGGimpn:MPN618.
PATRICi20022719. VBIMycPne110_0682.

Phylogenomic databases

eggNOGiCOG2812.
KOiK02343.
OMAiAINCLNW.
OrthoDBiEOG6WQD76.

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-664-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR012763. DNA_pol_III_sug/sutau.
IPR027417. P-loop_NTPase.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02397. dnaX_nterm. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiDPO3X_MYCPN
AccessioniPrimary (citable) accession number: P75177
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.