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P75177

- DPO3X_MYCPN

UniProt

P75177 - DPO3X_MYCPN

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Protein
DNA polymerase III subunit gamma/tau
Gene
dnaX, MPN_618, MP224
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 518ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
  3. nucleoside-triphosphatase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-664-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase III subunit gamma/tau (EC:2.7.7.7)
Gene namesi
Name:dnaX
Ordered Locus Names:MPN_618
ORF Names:MP224
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. DNA polymerase III complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 681681DNA polymerase III subunit gamma/tau
PRO_0000105499Add
BLAST

Proteomic databases

PaxDbiP75177.

Interactioni

Subunit structurei

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.

Protein-protein interaction databases

IntActiP75177. 5 interactions.
STRINGi272634.MPN618.

Structurei

3D structure databases

ProteinModelPortaliP75177.

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaX/STICHEL family.

Phylogenomic databases

eggNOGiCOG2812.
KOiK02343.
OMAiAINCLNW.
OrthoDBiEOG6WQD76.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR012763. DNA_pol_III_sug/sutau.
IPR027417. P-loop_NTPase.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02397. dnaX_nterm. 1 hit.

Sequencei

Sequence statusi: Complete.

P75177-1 [UniParc]FASTAAdd to Basket

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MRKVLYQKYR PTKFSDTVGQ DSIKRIIVNA ITQDQLPHGY IFAGERGTGK    50
TTFAKIIAKA INCLNWNGDV CNQCEACQAI NSNSAIDVFE IDAASKNGIN 100
DIRELAENVF NLPFKFKKKV YILDEAHMLT PQSWSGLLKT LEEAPDYVLF 150
IFATTEFNKI PITILSRCQS FFFKQITNDL IQQRLAEVAA KESIKITTDA 200
LVKLADLAQG SLRDGLSLLD QISNFSESKT ISLADVEKTF NLLDKEQKFG 250
FIEAVLSGDL KQSFHLIDNF ESQGINFVHF LRELFALTVD LYGYVKTGQI 300
AVVKPSDQTM AAKLRFHPKQ YALLVQAIEA NTGYGPSQLS LSDQIKAIVI 350
HYNNAVSKEP HIPAYTPVVQ TQSPAKEHVP SKTVEEAKPQ LPAKEPVLYK 400
VIEEPKVSSF VKDPVASKLI EQPQTIVQPE AQQEITEVEQ PTETSPAPAT 450
DLFGLAIKPE VVRKRGRRPL SVENTDFFQP AVKKLIQPVS KPAPIKLIEP 500
SDNNPVSIPI KLNRAVIAVS VYGHNDPKLV AHFQQLLDSF KREFTQAEKT 550
KDSSYLKQFS DKFTASDLSK VIKVLAASPF GLVLIFEDKE IATRLWKEAL 600
TEATAQATLL EIFQQNLFLS SFTLSEYETK VLAKVEQLTH KPQVLQLQQL 650
EQLSSTVVKK AQKTAAQEIA DTFFKGLYEE K 681
Length:681
Mass (Da):76,213
Last modified:February 1, 1997 - v1
Checksum:iE3DDC6A580FFCBCC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB95872.1.
PIRiS73550.
RefSeqiNP_110307.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95872; AAB95872; MPN_618.
GeneIDi877276.
KEGGimpn:MPN618.
PATRICi20022719. VBIMycPne110_0682.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB95872.1 .
PIRi S73550.
RefSeqi NP_110307.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P75177. 5 interactions.
STRINGi 272634.MPN618.

Proteomic databases

PaxDbi P75177.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB95872 ; AAB95872 ; MPN_618 .
GeneIDi 877276.
KEGGi mpn:MPN618.
PATRICi 20022719. VBIMycPne110_0682.

Phylogenomic databases

eggNOGi COG2812.
KOi K02343.
OMAi AINCLNW.
OrthoDBi EOG6WQD76.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-664-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR012763. DNA_pol_III_sug/sutau.
IPR027417. P-loop_NTPase.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR02397. dnaX_nterm. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiDPO3X_MYCPN
AccessioniPrimary (citable) accession number: P75177
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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