UvrABC system protein A - Mycoplasma pneumoniae (strain ATCC 29342 / M129)

Preferred order of sections

Names and origin

Protein names

Recommended name:
UvrABC system protein A
Short name=UvrA protein

Alternative name(s):
Excinuclease ABC subunit A

Gene names

Name:	uvrA
Ordered Locus Names:	MPN_619
ORF Names:	MP223

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma ›

Protein attributes

Sequence length	948 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate By similarity. HAMAP-Rule MF_00205
Subunit structure	Forms a heterotetramer with UvrB during the search for lesions By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. UvrA family. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	DNA damage DNA excision DNA repair SOS response
Cellular component	Cytoplasm
Domain	Repeat Zinc-finger
Ligand	ATP-binding DNA-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Excision nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC SOS response Inferred from electronic annotation. Source: HAMAP nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC nucleotide-excision repair Inferred from electronic annotation. Source: HAMAP transport Inferred from electronic annotation. Source: HAMAP
Cellular_component	ATP-binding cassette (ABC) transporter complex Inferred from electronic annotation. Source: HAMAP cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell excinuclease repair complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP ATPase activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: HAMAP excinuclease ABC activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 948

948

UvrABC system protein A HAMAP-Rule MF_00205

PRO_0000093066

Regions

Domain

5 – 601

597

ABC transporter 1

Domain

603 – 943

341

ABC transporter 2

Nucleotide binding

38 – 45

8

ATP 1 Potential

Zinc finger

259 – 286

28

C4-type HAMAP-Rule MF_00205

Nucleotide binding

647 – 654

8

ATP 2 Potential

Zinc finger

746 – 772

27

C4-type HAMAP-Rule MF_00205

Sequences

Sequence

Length

Mass (Da)

Tools

P75176 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 4466DE773D3B370C
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FASTA

948

105,426

        10         20         30         40         50         60 
MKPELKTNDF IRVKGARENN LKNVNIDIPK NQFVVITGLS GSGKSSLAFN TIYAEGRRRY 

        70         80         90        100        110        120 
LESLSSYARQ FLGNSDKPDV DSIEGLSPAI SIDQKTTSHN PRSTVGTVTE IYDYLRLLWA 

       130        140        150        160        170        180 
RIGIPFCPNG HGAIQTQTVN QIANQIFNLP VKSRIQILAP TIKNQRGTFA NEFAKYQQLG 

       190        200        210        220        230        240 
FLRVWVDGQV YTLDEEIKLD KNTKHNLSVV VDRIVINQDK QTLGRIVDAI EGVIKLTEGR 

       250        260        270        280        290        300 
IEVLLEDGKI LSFNKNHGCD QCGFSISELE PRLFSFNSPL GSCEYCKGLG FSYEPDVEKI 

       310        320        330        340        350        360 
IPNPLLSINE GGIDIFKNIV HGTSLDWQRF LSLINHYQIP LDQPLGQMDT DLVRMILEGS 

       370        380        390        400        410        420 
DEPIEIKTVS NSGAKNVRFE HYEGVAHLIK RRHLETSSQA SREWYSAYMS EITCKKCQGK 

       430        440        450        460        470        480 
KLTTNSLSVK LGGLDIISFT ELSIDKAIEF LLQIELNQEQ KKIGELALKE IINRLSFLKN 

       490        500        510        520        530        540 
VGLEYLNLAR RASTLSGGEA QRIRLATQIG SQLTGVLYVL DEPSIGLHQK DNDRLINTMM 

       550        560        570        580        590        600 
VMRDLGNTLL VVEHDSETML AADYLIDIGP KAGNQGGEVV AAGTPLEVME NPDSLTGQYL 

       610        620        630        640        650        660 
SGKKQIEVPK TRHAGNGRTL TLKGAKGNNL KNINVTIPLN KLVLVTGVSG SGKSTLINQT 

       670        680        690        700        710        720 
LVPILERLVN YKNVKPAPYK EIIGVNHIDK VVVVSQDPIG RTPRSNPATY VSVFDDIREL 

       730        740        750        760        770        780 
FANTKEAKAR GYTNSRFSFN VAGGRCDKCF GDGVIRIEMH FLPDVYVTCE MCDGKKYNPQ 

       790        800        810        820        830        840 
TLEVKYLGKS IFDVLQMSCQ EAYDFFKAIP NIARKLKLLC DVGLEYLQLG LNVTFLSGGE 

       850        860        870        880        890        900 
AQRIKLAKFL QKKATGKTLY VLDEPSTGLH IEDINKLLTV IQRIIKNGDS VIIIEHNLDI 

       910        920        930        940 
IKMADYIIDL GPEGGEKGGQ IIAQGTPEQL LNQVDKSYTA QYLAKILK

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References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB95871.1.
PIR	S73549.
RefSeq	NP_110308.1. NC_000912.1.
3D structure databases
ProteinModelPortal	P75176.
SMR	P75176. Positions 9-948.
ModBase	Search...
Protein-protein interaction databases
IntAct	P75176. 3 interactions.
STRING	272634.MPN619.
Proteomic databases
PaxDb	P75176.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB95871; AAB95871; MPN_619.
GeneID	876802.
KEGG	mpn:MPN619.
PATRIC	20022721. VBIMycPne110_0683.
Phylogenomic databases
eggNOG	COG0178.
KO	K03701.
OMA	GAIKGWD.
ProtClustDB	PRK00349.
Enzyme and pathway databases
BioCyc	MPNE272634:GJ6Z-665-MONOMER.
Family and domain databases
Gene3D	3.30.1490.20. 2 hits.
HAMAP	MF_00205. UvrA.
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR013815. ATP_grasp_subdomain_1. IPR004602. UvrA. [Graphical view]
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
TIGRFAMs	TIGR00630. uvra. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UVRA_MYCPN

Accession

Primary (citable) accession number: P75176

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents