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Protein

UvrABC system protein A

Gene

uvrA

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 458ATP 1UniRule annotation
Zinc fingeri259 – 28628C4-typeUniRule annotationAdd
BLAST
Nucleotide bindingi647 – 6548ATP 2UniRule annotation
Zinc fingeri746 – 77227C4-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. DNA binding Source: UniProtKB-HAMAP
  4. excinuclease ABC activity Source: UniProtKB-HAMAP
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. nucleotide-excision repair Source: UniProtKB-HAMAP
  2. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-665-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein AUniRule annotation
Short name:
UvrA proteinUniRule annotation
Alternative name(s):
Excinuclease ABC subunit AUniRule annotation
Gene namesi
Name:uvrAUniRule annotation
Ordered Locus Names:MPN_619
ORF Names:MP223
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. excinuclease repair complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 948948UvrABC system protein APRO_0000093066Add
BLAST

Proteomic databases

PaxDbiP75176.

Interactioni

Subunit structurei

Forms a heterotetramer with UvrB during the search for lesions.UniRule annotation

Protein-protein interaction databases

IntActiP75176. 3 interactions.
STRINGi272634.MPN619.

Structurei

3D structure databases

ProteinModelPortaliP75176.
SMRiP75176. Positions 9-948.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini316 – 595280ABC transporter 1UniRule annotationAdd
BLAST
Domaini615 – 944330ABC transporter 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. UvrA family.UniRule annotation
Contains 2 ABC transporter domains.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri259 – 28628C4-typeUniRule annotationAdd
BLAST
Zinc fingeri746 – 77227C4-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG0178.
KOiK03701.
OMAiVIEMNFL.
OrthoDBiEOG6QK4PS.

Family and domain databases

Gene3Di3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPiMF_00205. UvrA.
InterProiIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.
TIGRFAMsiTIGR00630. uvra. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75176-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPELKTNDF IRVKGARENN LKNVNIDIPK NQFVVITGLS GSGKSSLAFN
60 70 80 90 100
TIYAEGRRRY LESLSSYARQ FLGNSDKPDV DSIEGLSPAI SIDQKTTSHN
110 120 130 140 150
PRSTVGTVTE IYDYLRLLWA RIGIPFCPNG HGAIQTQTVN QIANQIFNLP
160 170 180 190 200
VKSRIQILAP TIKNQRGTFA NEFAKYQQLG FLRVWVDGQV YTLDEEIKLD
210 220 230 240 250
KNTKHNLSVV VDRIVINQDK QTLGRIVDAI EGVIKLTEGR IEVLLEDGKI
260 270 280 290 300
LSFNKNHGCD QCGFSISELE PRLFSFNSPL GSCEYCKGLG FSYEPDVEKI
310 320 330 340 350
IPNPLLSINE GGIDIFKNIV HGTSLDWQRF LSLINHYQIP LDQPLGQMDT
360 370 380 390 400
DLVRMILEGS DEPIEIKTVS NSGAKNVRFE HYEGVAHLIK RRHLETSSQA
410 420 430 440 450
SREWYSAYMS EITCKKCQGK KLTTNSLSVK LGGLDIISFT ELSIDKAIEF
460 470 480 490 500
LLQIELNQEQ KKIGELALKE IINRLSFLKN VGLEYLNLAR RASTLSGGEA
510 520 530 540 550
QRIRLATQIG SQLTGVLYVL DEPSIGLHQK DNDRLINTMM VMRDLGNTLL
560 570 580 590 600
VVEHDSETML AADYLIDIGP KAGNQGGEVV AAGTPLEVME NPDSLTGQYL
610 620 630 640 650
SGKKQIEVPK TRHAGNGRTL TLKGAKGNNL KNINVTIPLN KLVLVTGVSG
660 670 680 690 700
SGKSTLINQT LVPILERLVN YKNVKPAPYK EIIGVNHIDK VVVVSQDPIG
710 720 730 740 750
RTPRSNPATY VSVFDDIREL FANTKEAKAR GYTNSRFSFN VAGGRCDKCF
760 770 780 790 800
GDGVIRIEMH FLPDVYVTCE MCDGKKYNPQ TLEVKYLGKS IFDVLQMSCQ
810 820 830 840 850
EAYDFFKAIP NIARKLKLLC DVGLEYLQLG LNVTFLSGGE AQRIKLAKFL
860 870 880 890 900
QKKATGKTLY VLDEPSTGLH IEDINKLLTV IQRIIKNGDS VIIIEHNLDI
910 920 930 940
IKMADYIIDL GPEGGEKGGQ IIAQGTPEQL LNQVDKSYTA QYLAKILK
Length:948
Mass (Da):105,426
Last modified:February 1, 1997 - v1
Checksum:i4466DE773D3B370C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95871.1.
PIRiS73549.
RefSeqiNP_110308.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95871; AAB95871; MPN_619.
GeneIDi876802.
KEGGimpn:MPN619.
PATRICi20022721. VBIMycPne110_0683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95871.1.
PIRiS73549.
RefSeqiNP_110308.1. NC_000912.1.

3D structure databases

ProteinModelPortaliP75176.
SMRiP75176. Positions 9-948.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP75176. 3 interactions.
STRINGi272634.MPN619.

Proteomic databases

PaxDbiP75176.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB95871; AAB95871; MPN_619.
GeneIDi876802.
KEGGimpn:MPN619.
PATRICi20022721. VBIMycPne110_0683.

Phylogenomic databases

eggNOGiCOG0178.
KOiK03701.
OMAiVIEMNFL.
OrthoDBiEOG6QK4PS.

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-665-MONOMER.

Family and domain databases

Gene3Di3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPiMF_00205. UvrA.
InterProiIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.
TIGRFAMsiTIGR00630. uvra. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiUVRA_MYCPN
AccessioniPrimary (citable) accession number: P75176
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.