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P75176

- UVRA_MYCPN

UniProt

P75176 - UVRA_MYCPN

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Protein

UvrABC system protein A

Gene
uvrA, MPN_619, MP223
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 458ATP 1 Reviewed prediction
Zinc fingeri259 – 28628C4-typeUniRule annotationAdd
BLAST
Nucleotide bindingi647 – 6548ATP 2 Reviewed prediction
Zinc fingeri746 – 77227C4-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. DNA binding Source: UniProtKB-HAMAP
  4. excinuclease ABC activity Source: UniProtKB-HAMAP
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. nucleotide-excision repair Source: UniProtKB-HAMAP
  2. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-665-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein A
Short name:
UvrA protein
Alternative name(s):
Excinuclease ABC subunit A
Gene namesi
Name:uvrA
Ordered Locus Names:MPN_619
ORF Names:MP223
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. excinuclease repair complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 948948UvrABC system protein AUniRule annotationPRO_0000093066Add
BLAST

Proteomic databases

PaxDbiP75176.

Interactioni

Subunit structurei

Forms a heterotetramer with UvrB during the search for lesions By similarity.

Protein-protein interaction databases

IntActiP75176. 3 interactions.
STRINGi272634.MPN619.

Structurei

3D structure databases

ProteinModelPortaliP75176.
SMRiP75176. Positions 9-948.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini316 – 595280ABC transporter 1Add
BLAST
Domaini615 – 944330ABC transporter 2Add
BLAST

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri259 – 28628C4-typeUniRule annotationAdd
BLAST
Zinc fingeri746 – 77227C4-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG0178.
KOiK03701.
OMAiEGVLNNM.
OrthoDBiEOG6QK4PS.

Family and domain databases

Gene3Di3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPiMF_00205. UvrA.
InterProiIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.
TIGRFAMsiTIGR00630. uvra. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75176-1 [UniParc]FASTAAdd to Basket

« Hide

MKPELKTNDF IRVKGARENN LKNVNIDIPK NQFVVITGLS GSGKSSLAFN    50
TIYAEGRRRY LESLSSYARQ FLGNSDKPDV DSIEGLSPAI SIDQKTTSHN 100
PRSTVGTVTE IYDYLRLLWA RIGIPFCPNG HGAIQTQTVN QIANQIFNLP 150
VKSRIQILAP TIKNQRGTFA NEFAKYQQLG FLRVWVDGQV YTLDEEIKLD 200
KNTKHNLSVV VDRIVINQDK QTLGRIVDAI EGVIKLTEGR IEVLLEDGKI 250
LSFNKNHGCD QCGFSISELE PRLFSFNSPL GSCEYCKGLG FSYEPDVEKI 300
IPNPLLSINE GGIDIFKNIV HGTSLDWQRF LSLINHYQIP LDQPLGQMDT 350
DLVRMILEGS DEPIEIKTVS NSGAKNVRFE HYEGVAHLIK RRHLETSSQA 400
SREWYSAYMS EITCKKCQGK KLTTNSLSVK LGGLDIISFT ELSIDKAIEF 450
LLQIELNQEQ KKIGELALKE IINRLSFLKN VGLEYLNLAR RASTLSGGEA 500
QRIRLATQIG SQLTGVLYVL DEPSIGLHQK DNDRLINTMM VMRDLGNTLL 550
VVEHDSETML AADYLIDIGP KAGNQGGEVV AAGTPLEVME NPDSLTGQYL 600
SGKKQIEVPK TRHAGNGRTL TLKGAKGNNL KNINVTIPLN KLVLVTGVSG 650
SGKSTLINQT LVPILERLVN YKNVKPAPYK EIIGVNHIDK VVVVSQDPIG 700
RTPRSNPATY VSVFDDIREL FANTKEAKAR GYTNSRFSFN VAGGRCDKCF 750
GDGVIRIEMH FLPDVYVTCE MCDGKKYNPQ TLEVKYLGKS IFDVLQMSCQ 800
EAYDFFKAIP NIARKLKLLC DVGLEYLQLG LNVTFLSGGE AQRIKLAKFL 850
QKKATGKTLY VLDEPSTGLH IEDINKLLTV IQRIIKNGDS VIIIEHNLDI 900
IKMADYIIDL GPEGGEKGGQ IIAQGTPEQL LNQVDKSYTA QYLAKILK 948
Length:948
Mass (Da):105,426
Last modified:February 1, 1997 - v1
Checksum:i4466DE773D3B370C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB95871.1.
PIRiS73549.
RefSeqiNP_110308.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95871; AAB95871; MPN_619.
GeneIDi876802.
KEGGimpn:MPN619.
PATRICi20022721. VBIMycPne110_0683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB95871.1 .
PIRi S73549.
RefSeqi NP_110308.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75176.
SMRi P75176. Positions 9-948.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P75176. 3 interactions.
STRINGi 272634.MPN619.

Proteomic databases

PaxDbi P75176.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB95871 ; AAB95871 ; MPN_619 .
GeneIDi 876802.
KEGGi mpn:MPN619.
PATRICi 20022721. VBIMycPne110_0683.

Phylogenomic databases

eggNOGi COG0178.
KOi K03701.
OMAi EGVLNNM.
OrthoDBi EOG6QK4PS.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-665-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPi MF_00205. UvrA.
InterProi IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view ]
Pfami PF00005. ABC_tran. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 5 hits.
TIGRFAMsi TIGR00630. uvra. 1 hit.
PROSITEi PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiUVRA_MYCPN
AccessioniPrimary (citable) accession number: P75176
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 14, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi