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P75176

- UVRA_MYCPN

UniProt

P75176 - UVRA_MYCPN

Protein

UvrABC system protein A

Gene

uvrA

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi38 – 458ATP 1UniRule annotation
    Zinc fingeri259 – 28628C4-typeUniRule annotationAdd
    BLAST
    Nucleotide bindingi647 – 6548ATP 2UniRule annotation
    Zinc fingeri746 – 77227C4-typeUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. DNA binding Source: UniProtKB-HAMAP
    4. excinuclease ABC activity Source: UniProtKB-HAMAP
    5. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. nucleotide-excision repair Source: UniProtKB-HAMAP
    2. SOS response Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Excision nuclease

    Keywords - Biological processi

    DNA damage, DNA excision, DNA repair, SOS response

    Keywords - Ligandi

    ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-665-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UvrABC system protein AUniRule annotation
    Short name:
    UvrA proteinUniRule annotation
    Alternative name(s):
    Excinuclease ABC subunit AUniRule annotation
    Gene namesi
    Name:uvrAUniRule annotation
    Ordered Locus Names:MPN_619
    ORF Names:MP223
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. excinuclease repair complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 948948UvrABC system protein APRO_0000093066Add
    BLAST

    Proteomic databases

    PaxDbiP75176.

    Interactioni

    Subunit structurei

    Forms a heterotetramer with UvrB during the search for lesions.UniRule annotation

    Protein-protein interaction databases

    IntActiP75176. 3 interactions.
    STRINGi272634.MPN619.

    Structurei

    3D structure databases

    ProteinModelPortaliP75176.
    SMRiP75176. Positions 9-948.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini316 – 595280ABC transporter 1UniRule annotationAdd
    BLAST
    Domaini615 – 944330ABC transporter 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily. UvrA family.UniRule annotation
    Contains 2 ABC transporter domains.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri259 – 28628C4-typeUniRule annotationAdd
    BLAST
    Zinc fingeri746 – 77227C4-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0178.
    KOiK03701.
    OMAiEGVLNNM.
    OrthoDBiEOG6QK4PS.

    Family and domain databases

    Gene3Di3.30.1490.20. 2 hits.
    3.40.50.300. 4 hits.
    HAMAPiMF_00205. UvrA.
    InterProiIPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR013815. ATP_grasp_subdomain_1.
    IPR027417. P-loop_NTPase.
    IPR004602. UvrA.
    [Graphical view]
    PfamiPF00005. ABC_tran. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 5 hits.
    TIGRFAMsiTIGR00630. uvra. 1 hit.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P75176-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPELKTNDF IRVKGARENN LKNVNIDIPK NQFVVITGLS GSGKSSLAFN    50
    TIYAEGRRRY LESLSSYARQ FLGNSDKPDV DSIEGLSPAI SIDQKTTSHN 100
    PRSTVGTVTE IYDYLRLLWA RIGIPFCPNG HGAIQTQTVN QIANQIFNLP 150
    VKSRIQILAP TIKNQRGTFA NEFAKYQQLG FLRVWVDGQV YTLDEEIKLD 200
    KNTKHNLSVV VDRIVINQDK QTLGRIVDAI EGVIKLTEGR IEVLLEDGKI 250
    LSFNKNHGCD QCGFSISELE PRLFSFNSPL GSCEYCKGLG FSYEPDVEKI 300
    IPNPLLSINE GGIDIFKNIV HGTSLDWQRF LSLINHYQIP LDQPLGQMDT 350
    DLVRMILEGS DEPIEIKTVS NSGAKNVRFE HYEGVAHLIK RRHLETSSQA 400
    SREWYSAYMS EITCKKCQGK KLTTNSLSVK LGGLDIISFT ELSIDKAIEF 450
    LLQIELNQEQ KKIGELALKE IINRLSFLKN VGLEYLNLAR RASTLSGGEA 500
    QRIRLATQIG SQLTGVLYVL DEPSIGLHQK DNDRLINTMM VMRDLGNTLL 550
    VVEHDSETML AADYLIDIGP KAGNQGGEVV AAGTPLEVME NPDSLTGQYL 600
    SGKKQIEVPK TRHAGNGRTL TLKGAKGNNL KNINVTIPLN KLVLVTGVSG 650
    SGKSTLINQT LVPILERLVN YKNVKPAPYK EIIGVNHIDK VVVVSQDPIG 700
    RTPRSNPATY VSVFDDIREL FANTKEAKAR GYTNSRFSFN VAGGRCDKCF 750
    GDGVIRIEMH FLPDVYVTCE MCDGKKYNPQ TLEVKYLGKS IFDVLQMSCQ 800
    EAYDFFKAIP NIARKLKLLC DVGLEYLQLG LNVTFLSGGE AQRIKLAKFL 850
    QKKATGKTLY VLDEPSTGLH IEDINKLLTV IQRIIKNGDS VIIIEHNLDI 900
    IKMADYIIDL GPEGGEKGGQ IIAQGTPEQL LNQVDKSYTA QYLAKILK 948
    Length:948
    Mass (Da):105,426
    Last modified:February 1, 1997 - v1
    Checksum:i4466DE773D3B370C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95871.1.
    PIRiS73549.
    RefSeqiNP_110308.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB95871; AAB95871; MPN_619.
    GeneIDi876802.
    KEGGimpn:MPN619.
    PATRICi20022721. VBIMycPne110_0683.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95871.1 .
    PIRi S73549.
    RefSeqi NP_110308.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75176.
    SMRi P75176. Positions 9-948.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P75176. 3 interactions.
    STRINGi 272634.MPN619.

    Proteomic databases

    PaxDbi P75176.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB95871 ; AAB95871 ; MPN_619 .
    GeneIDi 876802.
    KEGGi mpn:MPN619.
    PATRICi 20022721. VBIMycPne110_0683.

    Phylogenomic databases

    eggNOGi COG0178.
    KOi K03701.
    OMAi EGVLNNM.
    OrthoDBi EOG6QK4PS.

    Enzyme and pathway databases

    BioCyci MPNE272634:GJ6Z-665-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 2 hits.
    3.40.50.300. 4 hits.
    HAMAPi MF_00205. UvrA.
    InterProi IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR013815. ATP_grasp_subdomain_1.
    IPR027417. P-loop_NTPase.
    IPR004602. UvrA.
    [Graphical view ]
    Pfami PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 5 hits.
    TIGRFAMsi TIGR00630. uvra. 1 hit.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiUVRA_MYCPN
    AccessioniPrimary (citable) accession number: P75176
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3